Abstract：
:Temporal lobe epilepsy has been usually associated with progressive brain atrophy due to neuronal cell loss. However, recent animal models demonstrated a dual effect of epileptic seizures with initial enhancement of hippocampal neurogenesis followed by abnormal astrocyte proliferation and neurogenesis depletion in the chronic stage. Our aim was to test for the hypothesized bidirectional pattern of epilepsy-associated brain remodeling in the context of the presence and absence of mesial temporal lobe sclerosis. We acquired MRIs from a large cohort of mesial temporal lobe epilepsy patients with or without hippocampus sclerosis on radiological examination. The statistical analysis tested explicitly for common and differential brain patterns between the two patients' cohorts and healthy controls within the computational anatomy framework of voxel-based morphometry. The main effect of disease was associated with continuous hippocampus volume loss ipsilateral to the seizure onset zone in both temporal lobe epilepsy cohorts. The post hoc simple effects tests demonstrated bilateral hippocampus volume increase in the early epilepsy stages in patients without hippocampus sclerosis. Early age of onset and longer disease duration correlated with volume decrease in the ipsilateral hippocampus. Our findings of seizure-induced hippocampal remodeling are associated with specific patterns of mesial temporal lobe atrophy that are modulated by individual clinical phenotype features. Directionality of hippocampus volume changes strongly depends on the chronicity of disease. Specific anatomy differences represent a snapshot within a progressive continuum of seizure-induced structural remodeling.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Roggenhofer E,Santarnecchi E,Muller S,Kherif F,Wiest R,Seeck M,Draganski Bdoi
10.1007/s00415-019-09546-zsubject
Has Abstractpub_date
2019-12-01 00:00:00pages
3150-3159issue
12eissn
0340-5354issn
1432-1459pii
10.1007/s00415-019-09546-zjournal_volume
266pub_type
杂志文章abstract：BACKGROUND:Transcranial direct current stimulation (tDCS) has been investigated as a tool for dysphagia recovery after stroke in several single-center randomized controlled trials (RCT). OBJECTIVE:The aim of this investigation was to quantitatively evaluate the effect of tDCS on dysphagia recovery after a stroke utili...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10142-9
更新日期：2021-01-01 00:00:00
abstract：:The objective of this study is to determine the current distribution of clinical phenotypes and to estimate future trends of ALS incidence in Western societies. We report on a clinical-epidemiological registry with a capture-recapture rate of >80% and population-based case-control study in ALS patients in South Wester...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8413-3
更新日期：2017-04-01 00:00:00
abstract：:The purpose of this study was to evaluate the contribution of posterior circulation to memory function by comparing memory scores between patients with and without a foetal-type posterior cerebral artery (FTP) during the intracarotid amobarbital procedure (IAP) in epilepsy patients. Patients undergoing bilateral IAP b...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6391-4
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To investigate the efficacy of acupuncture on stroke recovery compared to an inert placebo. DESIGN:Placebo-controlled, randomised, clinical trial. SETTING:Post-stroke rehabilitation wards in five NHS hospitals in the UK. SUBJECTS:Patients between 4 and 10 days after their first stroke. INTERVENTIONS AND O...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-008-0790-1
更新日期：2008-06-01 00:00:00
abstract：:We report the familial occurrence and apparent autosomal dominant inheritance of Sneddon's syndrome with variable clinical expression. The proband, a 40-year-old woman, presented with livedo reticularis and progressive neurological deterioration following a stroke. The diagnosis was confirmed by cerebral angiogram and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00936890
更新日期：1995-02-01 00:00:00
abstract：:Deep brain stimulation of the subthalamic nucleus (STN) is an effective treatment modality for motor symptoms of advanced Parkinson's disease. Recent studies focus on exploring its possible effects on cognition and behavior. We present a case with acute cognitive dysfunction due to misalignment of the electrodes to th...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5103-9
更新日期：2009-08-01 00:00:00
abstract：:Raised intracranial pressure in association with spinal meningeal cysts has rarely been reported. We describe four patients in whom evidence of paroxysmal raised intracranial pressure was found in association with spinal meningeal cysts. Cerebrospinal fluid diversion procedures have previously been shown to relieve lo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0430-y
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:Patients with classic ataxia-telangiectasia (A-T) generally die in the second or third decade of life. Clinical descriptions of A-T tend to focus on the symptoms at presentation. However, during the course of the disease, other symptoms and complications emerge. As long-term survivors with classic A-T develop...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09641-1
更新日期：2020-03-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7006-z
更新日期：2013-10-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10216-8
更新日期：2020-09-11 00:00:00
abstract：:Muscle samples obtained in patients with different neuromuscular diseases were stored at 0 degree C for periods of 6-12h and were subsequently frozen for histochemical processing. Compared to reference samples which had been immediately frozen, the individual test sections displayed different degrees of swelling of th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313934
更新日期：1984-01-01 00:00:00
abstract：:The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050351
更新日期：1999-04-01 00:00:00
abstract：:Circulating and cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels represent a reliable indicator of disease activity and axonal damage in different neuroinflammatory conditions. Recently, high CSF NfL levels have been detected in active autoimmune encephalitis, as opposed to significant lower levels aft...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09306-z
更新日期：2019-07-01 00:00:00
abstract：:Botulinum neurotoxin (BoNT) is an effective treatment for cervical dystonia (CD). Long-term changes of several variables, including the dose of BoNT, in these patients is largely unknown. We reviewed the clinical charts of 275 patients with CD treated with BoNT type A (BoNT-A) for at least 5 years since 1989 at ten te...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-010-5880-1
更新日期：2011-06-01 00:00:00
abstract：:Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms and to study the rel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6140-8
更新日期：2012-01-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8588-7
更新日期：2017-09-01 00:00:00
abstract：:Elevated intracranial intravenous pressure is not routinely measured in clinical practice. Indirect evidence of increased venous pressure is reflected in the size change of the cerebral sinuses and the presence of venous infarctions. The purpose of this study is to evaluate the role of brain perfusion venous time-dens...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-5955-7
更新日期：2011-08-01 00:00:00
abstract：:We describe three patients in whom an isolated sixth nerve palsy was the only clinical symptom or sign of multiple sclerosis (MS). Data were collected prospectively over 6 years on these three patients, who showed no other signs of brainstem dysfunction or prior symptoms; in addition. Retrospective analysis of all pat...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150070114
更新日期：2000-09-01 00:00:00
abstract：UNLABELLED:The aim of the study was to assess adjunctive intravenous dexamethasone in adult community-acquired bacterial meningitis (BM) in daily practice. Analysis of consecutive patients (1990-2009) with acute community-acquired bacterial meningitis in a single centre in Zagreb, Croatia, N = 304. Adjusted relative ri...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6150-6
更新日期：2012-02-01 00:00:00
abstract：:Autoradiographic investigations with 3H-thymidine were performed on cerebrospinal fluid (CSF) cells from a case of meningeal carcinomatosis following carcinoma of the breast. The cells were found to be anaplastic histologically. Within a period of 12 days 3 X 25 mg methotrexate were injected into the subarachnoid spac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00316271
更新日期：1976-10-04 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10127-8
更新日期：2021-01-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6734-9
更新日期：2013-04-01 00:00:00
abstract：:Most inflammatory neuropathies, both acute and chronic, probably result from an immune attack against antigens of the peripheral nervous system. Specific antibodies in serum that react with the peripheral nervous system have been described in a number of inflammatory neuropathies. We review the pathophysiological sign...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150070170
更新日期：2000-06-01 00:00:00
abstract：:The prevalence of clinical and electrophysiological signs of peripheral nerve disease was evaluated in 151 patients with chronic obstructive pulmonary disease. Patients with concomitant disorders affecting the peripheral nervous system were excluded. Thirty patients had clinical signs of a mild sensorimotor and distal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314624
更新日期：1990-07-01 00:00:00
abstract：:Dementia has a reversible cause in some cases, and these should be diagnosed without over-investigating the many patients with irreversible disease. We prospectively studied the prevalence of reversible dementia in a memory clinic, determined the added value of investigations compared with clinical examination and ass...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/pl00007724
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:The spinocerebellar ataxias (SCAs), are rare neurodegenerative disorders caused by distinct genetic mutations. Clinically, the SCAs are characterised by progressive ataxia and a variety of other features, including cognitive dysfunction. The latter is consistent with a growing body of evidence supporting a...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0680-6
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:The variants of primary progressive aphasia (PPA) are predominantly diagnosed on the basis of specific profiles of language impairments. Deficits in other cognitive domains and their evolution over time are less well documented. This study examined the cognitive profiles of the PPA variants over time and dete...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10382-9
更新日期：2021-01-08 00:00:00
abstract：:A patient with chronic relapsing inflammatory demyelinating polyneuropathy was successfully treated with plasma exchanges and cyclosporin A (CsA). Dynamometric measurements of hand force during the time of CsA treatment showed a highly significant correlation between hand force and CsA blood levels. The largest influe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314752
更新日期：1990-08-01 00:00:00
abstract：:Multi-modality evoked potentials and computed cranial tomography (CT) were performed in ten patients with Wilson's disease to determine if any of these studies would correlate reliably with neurologic status. While all four patients with CT abnormality had neurologic signs, two additional patients with neurologic find...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314035
更新日期：1985-01-01 00:00:00
abstract：:Cerebellar ataxias (CAs) represent a heterogeneous group of sporadic or inherited disorders. The clinical spectrum of CAs is continuously expanding. Our understanding of the mechanisms leading to the clinical deficits has improved over these last decades, in particular thanks to progress in genetics, neuroimaging and ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09717-3
更新日期：2020-04-01 00:00:00
