Abstract:
:Suicide is a leading cause of death in Huntington's disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of suicidal ideation in premanifest and manifest patients and re-evaluate them using the largest currently existing clinical dataset from the ongoing observational study "Enroll-HD" (N = 5709). Large scale studies yielded important insights regarding suicidal ideation in HD. However, estimated prevalence rates vary among studies and risk factors are still poorly understood. According to the Enroll-HD data, pre- and manifest disease stages are associated with current (5.8-10%) and a history of suicidal ideation (18.6-30.9%). Throughout the course of HD, a history of suicidal ideation and the presence of depressive symptoms were strongly associated with current suicidal ideation. However, while for premanifest individuals, socio-demographics and activities of daily living appear to be important, in manifest patients, suicidal ideation is more closely linked to anxiety, irritability, psychosis, and apathy. These results highlight the importance of treating depressive symptoms in patients with HD and addressing potential suicidal ideation during clinical monitoring. The relevance of risk factors may differ among premanifest and manifest patients.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Honrath P,Dogan I,Wudarczyk O,Görlich KS,Votinov M,Werner CJ,Schumann B,Overbeck RT,Schulz JB,Landwehrmeyer BG,Gur RE,Habel U,Reetz K,Enroll-HD investigators.doi
10.1007/s00415-018-9013-6subject
Has Abstractpub_date
2018-11-01 00:00:00pages
2548-2561issue
11eissn
0340-5354issn
1432-1459pii
10.1007/s00415-018-9013-6journal_volume
265pub_type
杂志文章,评审abstract::Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System with multifocal areas of demyelination. Although its etiology and pathogenesis remain controversial, several lines of evidence indicate that MS is mediated by a misdirected immune response against one or several myelin proteins. The invol...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s004150200026
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journal_title:Journal of neurology
pub_type: 信件
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1007/s00415-020-10140-x
更新日期:2021-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09670-w
更新日期:2020-04-01 00:00:00
abstract:INTRODUCTION:PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE). METHODS:We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9095-1
更新日期:2018-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-007-2013-6
更新日期:2007-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-016-8114-3
更新日期:2016-06-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
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更新日期:2017-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7230-6
更新日期:2014-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09817-0
更新日期:2020-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-014-7303-1
更新日期:2014-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09686-2
更新日期:2020-04-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-010-5511-x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Dermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal DNA-damage response. METHODS:Dermic fibroblasts were obtai...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09704-8
更新日期:2020-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312524
更新日期:1975-01-01 00:00:00
abstract::Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literatu...
journal_title:Journal of neurology
pub_type: 指南,杂志文章,评审
doi:10.1007/s00415-016-8304-z
更新日期:2017-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313465
更新日期:1981-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0491-6
更新日期:2007-08-01 00:00:00
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journal_title:Journal of neurology
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1977-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314376
更新日期:1989-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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