Abstract：
BACKGROUND:Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces. EPVS have been linked to small vessel disease. Some studies have also indicated an association of EPVS to neuroinflammation and/or neurodegeneration. However, there is conflicting evidence with regards to their potential as a clinically relevant imaging biomarker in multiple sclerosis (MS). METHODS:To perform a systematic review and meta-analysis of EPVS as visualized by MRI in MS. Nine out of 299 original studies addressing EPVS in humans using MRI were eligible for the systematic review and meta-analysis including a total of 457 MS patients and 352 control subjects. RESULTS:In MS, EPVS have been associated with cognitive decline, contrast-enhancing MRI lesions, and brain atrophy. Yet, these associations were not consistent between studies. The meta-analysis revealed that MS patients have greater EPVS prevalence (odds ratio = 4.61, 95% CI = [1.84; 11.60], p = 0.001) as well as higher EPVS counts (standardized mean difference [SMD] = 0.46, 95% CI = [0.26; 0.67], p < 0.001) and larger volumes (SMD = 0.88, 95% CI = [0.19; 1.56], p = 0.01) compared to controls. CONCLUSIONS:Available literature suggests a higher EPVS burden in MS patients compared to controls. The association of EPVS to neuroinflammatory or -degenerative pathology in MS remains inconsistent. Thus, there is currently insufficient evidence supporting EPVS as diagnostic and/or prognostic marker in MS. In order to benefit future comparisons of studies, we propose recommendations on EPVS assessment standardization in MS. PROSPERO No: CRD42019133946.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Granberg T,Moridi T,Brand JS,Neumann S,Hlavica M,Piehl F,Ineichen BVdoi
10.1007/s00415-020-09971-5subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3199-3212issue
11eissn
0340-5354issn
1432-1459pii
10.1007/s00415-020-09971-5journal_volume
267pub_type
杂志文章abstract：PURPOSE:To develop specific diagnostic ultrasound (US) models for hereditary motor and sensory neuropathies (HMSN) in patients with primarily demyelinating or axonal polyneuropathies (PNP) according to standard nerve conduction studies (NCS) criteria. METHODS:Single-centre, examiner-blinded cross-sectional study in ac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8687-5
更新日期：2018-01-01 00:00:00
abstract：:The follow-up of neurophysiological tests (brain-stem auditory evoked potentials; blink reflex; sensory, motor and visual evoked potentials) and CT was investigated in 21 patients with late-onset cerebellar ataxia (CA) or multiple system atrophy. The study included an initial investigation and a follow-up examination ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00857523
更新日期：1993-01-01 00:00:00
abstract：:From a family with essential familial myoclonus, 150 members in eight generations were studied. Twenty-five of them suffered from myoclonus of varying severity. The findings in routine examinations of blood, urine and cerebrospinal fluid, EEG and skull radiographs were normal. Therapeutic trials did not produce lastin...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313626
更新日期：1983-01-01 00:00:00
abstract：:Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal sclerosis is an epileptic syndrome. To address this issue, we searched for discriminative semiological features...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8441-z
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Delayed ischaemic neurological deficit (DID) following subarachnoid haemorrhage from aneurysm rupture (aSAH) is a serious complication and a major cause of mortality and morbidity. No empirical estimates of resource use and costs of patients with delayed ischaemic deficit compared to those without have been ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-0034-z
更新日期：2009-03-01 00:00:00
abstract：:Peripheral neuropathies have various causes, both infectious and non-infectious. When we think of "epidemics", we often refer to an infectious or even post-infectious origin. Nevertheless, the history of mankind is marked by episodes of epidemics of peripheral neuropathies of non-infectious nature, either of nutrition...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10216-8
更新日期：2020-09-11 00:00:00
abstract：:During a period of 42 months, we studied the prevalence of epilepsy in a specific health district, composing by four towns with 98,405 inhabitants older than 10 years. This has been accomplished by a two-phase cross-sectional study. The prevalence rate observed was 4.12/1000 inhabitants for all types of epilepsy. No s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170091
更新日期：2001-09-01 00:00:00
abstract：:The spinocerebellar ataxias (SCAs) with autosomal dominant inheritance are a clinically and genetically heterogeneous group of neurological disorders with overlapping as well as highly variable phenotypes primarily affecting the cerebellum. To date, 28 different loci have been identified. Nine SCAs are caused by repea...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5209-0
更新日期：2009-11-01 00:00:00
abstract：:Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson's disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear. To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7835-z
更新日期：2015-10-01 00:00:00
abstract：:Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314325
更新日期：1975-08-04 00:00:00
abstract：:A consecutive series of 327 patients (188 males, 139 females; mean age 68.4, SEM 1.33) were hospitalized within 12 h of the onset of their first-ever hemispheric infarct. Three groups of patients were identified: diabetics (n = 70), non-diabetic hyperglycaemics (n = 93) and normoglycaemics (n = 164). Case-fatality rat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00812155
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) improves early clinical outcome in patients with acute ischemic stroke but insights on determinants of long-term outcome after MT treatment are scarce. METHODS:Data from stroke patients with anterior circulation large vessel occlusion of a prospective MT registry (01...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09670-w
更新日期：2020-04-01 00:00:00
abstract：:Temporal lobe epilepsy has been usually associated with progressive brain atrophy due to neuronal cell loss. However, recent animal models demonstrated a dual effect of epileptic seizures with initial enhancement of hippocampal neurogenesis followed by abnormal astrocyte proliferation and neurogenesis depletion in the...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09546-z
更新日期：2019-12-01 00:00:00
abstract：:There is growing evidence that intravenous immunoglobulins (IVIG) are effective in some neuroimmunological disorders of childhood. This short review summarizes the evidence-based indications and recommendations of IVIG therapy in these disorders. Despite considerable efforts to define the role and mechanisms of IVIG, ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-5014-y
更新日期：2006-09-01 00:00:00
abstract：:We report a case of central European tick-borne encephalitis with cervical myelitis presenting clinically as a lower motor neuron syndrome of the upper limbs with proximal asymmetrical pareses and atrophies. There were no sensory deficits nor signs of lesions of the spinal pathways or signs of encephalitis or meningit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050537
更新日期：1999-12-01 00:00:00
abstract：:The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phos...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312524
更新日期：1975-01-01 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegenerative disorders, suc...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6970-7
更新日期：2013-09-01 00:00:00
abstract：:Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0825-y
更新日期：2002-09-01 00:00:00
abstract：:Central nervous system localizations of sarcoidosis may be refractory to conventional treatment such as steroids and immunosuppressive drugs. Infliximab, a TNF-α antagonist chimeric antibody, has been shown to be effective for treatment of these localizations. The aim of this study was to evaluate the efficacy and saf...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8444-9
更新日期：2017-05-01 00:00:00
abstract：:Chronic neuropathy is the most frequent condition affecting the peripheral nervous system. It includes symmetrical polyneuropathies, multifocal mononeuropathies, mononeuropathies and radiculopathies. Mononeuropathies are mainly due to compression or entrapment and are not discussed in this review, which focuses on pol...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050326
更新日期：1999-03-01 00:00:00
abstract：:This observational study examined the outcome of two different therapeutic strategies in the treatment of chronic neuropathic pain by including pregabalin (PGB) as mono- or add-on therapy in one of two treatment options. Patients with a pain score of > or =4, refractory to usual care for neuropathic pain for at least ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5504-9
更新日期：2010-08-01 00:00:00
abstract：:Fatigue is a common and frequently disabling symptom of multiple sclerosis (MS). The aim of this study was to develop the Fatigue index Kliniken Schmieder (FKS) for detecting motor fatigue in patients with MS using kinematic gait analysis. The FKS relies on the chaos theoretical term "attractor", which, if unchanged, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7415-7
更新日期：2014-09-01 00:00:00
abstract：:Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-015-7963-5
更新日期：2016-04-01 00:00:00
abstract：:Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) is a rare, autosomal recessive disorder caused by mutations in the gene encoding a mitochondrial aspartyl-tRNA synthetase, DARS2. The disease is characterized by progressive spastic ataxia and magnetic resonance imaging (MRI) sh...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6176-9
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Trans-active response DNA-binding protein of 43 kDa (TDP-43) can be detected in up to 63% of autopsy-confirmed Lewy body disease (LBD) cases. It is unclear whether TDP-43 is associated with a decreased likelihood of a clinical diagnosis of probable dementia with Lewy bodies (pDLB) during life. METHODS:In an...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09718-2
更新日期：2020-05-01 00:00:00
abstract：:Hemichorea-hemiballism (HCHB) was infrequently related to cortical lesions such as tumor or infarction. Although functional derangement of the basal ganglia (BG) or the thalamus (Th) was suggested, pathomechanism of HCHB secondary to cortical lesions remains uncertain. We recruited the patients with HCHB secondary to ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7096-7
更新日期：2013-12-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-018-9066-6
更新日期：2018-12-01 00:00:00
abstract：:Tibial muscular dystrophy (TMD) or Udd myopathy is an autosomal dominant distal myopathy with late onset, at first described in the Finnish population. We report here the first Italian cases of TTN mutated titinopathy. The proband, a 60 year-old female, had the first muscular signs at the age of 59 years, with difficu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5372-3
更新日期：2010-04-01 00:00:00
abstract：:The finding of a mutation in the alpha-synuclein gene in a rare autosomal dominant form of idiopathic Parkinson's disease (IPD), has prompted increased interest in identifying genes that account for the more common sporadic form. A number of association studies have suggested that functional polymorphisms in genes tha...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050258
更新日期：1998-10-01 00:00:00
abstract：:To clarify the changes of cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials induced by air-conducted sound (ACS) and bone-conducted vibration (BCV) in patients with vestibular neuritis (VN), patients with VN (n = 30) and normal controls (n = 45) underwent recording of cVEMP and oVEMP in respons...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6953-8
更新日期：2013-08-01 00:00:00
