当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease.

Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson's disease.

Abstract：

:Cerebello-thalamo-cortical circuit has been indicated important for tremor in Parkinson's disease (PD), but the role of dentate nucleus (DN) in parkinsonian tremor remains unclear. To investigate whether DN plays a role in PD tremor, we recruited 50 PD and 29 age-matched health controls (HC). The patients were divided into tremor-dominant (TD) and non-tremor-dominant (NTD) groups. We collected resting-state fMRIs data for each subject. The bilateral DN was then chosen as the region of interest to examine PD tremor-related network changes, as well as its correlation with tremor severity. Voxel-wise functional connectivity analysis revealed that the bilateral DN had higher connectivity with the bilateral cerebellar anterior lobe, and had lower connectivity with the bilateral prefrontal cortex in TD compared to the HC and NTD groups. Functional connectivity of the bilateral DN with the bilateral cerebellar posterior lobe was also higher in TD than NTD group. Functional connectivity between the bilateral DN and the bilateral cerebellar posterior lobe showed positive correlation with tremor severity, while that between the bilateral DN and the bilateral prefrontal cortex displayed negative correlation. Our study demonstrates higher dentato-cerebellar connectivity and lower dentato-prefrontal connectivity in TD patients, which might be involved in the pathogenesis of PD tremor. And we conclude that DN might be associated with the pathogenesis of PD tremor.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Ma H,Chen H,Fang J,Gao L,Ma L,Wu T,Hou Y,Zhang J,Feng T

doi

10.1007/s00415-015-7835-z

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

2247-56

issue

10

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-015-7835-z

journal_volume

262

pub_type

杂志文章

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Ataxia telangiectasia in identical twins: unusual features.

    abstract：:The cases of identical twins with ataxia telangiectasia, early intellectual impairment and progressive spasticity are reported. Immunological tests revealed reduced levels of serum and salivary IgA, increased B cells, reduced T cells and raised alpha-fetoprotein. CT scan performed in one of the twins was normal. The p...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314163

    authors： Meshram CM,Sawhney IM,Prabhakar S,Chopra JS

    更新日期：1986-10-01 00:00:00

  • Medial temporal lobe epilepsy associated with hippocampal sclerosis is a distinctive syndrome.

    abstract：:Epileptic syndromes are distinctive disorders with specific features, which when taken together, permit a specific diagnosis. There is actually a debate on that medial temporal lobe epilepsy with hippocampal sclerosis is an epileptic syndrome. To address this issue, we searched for discriminative semiological features...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-017-8441-z

    authors： No YJ,Zavanone C,Bielle F,Nguyen-Michel VH,Samson Y,Adam C,Navarro V,Dupont S

    更新日期：2017-05-01 00:00:00

  • Electromyographic findings in the so-called non-progressive myopathies.

    abstract：:Electrophysiological findings in 40 cases of non-progressive myopathies are reported, and compared with a group of 20 cases of Duchenne progressive muscular dystrophy and a control group. In all cases the electrophysiological changes were of the mild s. c. myogenic type. The involvement of proximal and distal muscles ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313234

    authors： Hausmanowa-Petrusewicz I,Ryniewicz B

    更新日期：1976-02-13 00:00:00

  • Cerebrospinal fluid proteins and cells in normal-pressure hydrocephalus.

    abstract：:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No cha...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313729

    authors： Wikkelsø C,Blomstrand C

    更新日期：1982-01-01 00:00:00

  • Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.

    abstract：:To further evaluate (1) transcranial sonography (TCS) for (pre)clinical diagnosis of Parkinson's disease (PD) and (2) to examine asymptomatic carriers of Parkin mutations we investigated substantia nigra (SN) hyperechogenicity in PD patients and unaffected subjects with and without Parkin mutations. The area (aSN) of ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-007-0567-y

    authors： Hagenah JM,König IR,Becker B,Hilker R,Kasten M,Hedrich K,Pramstaller PP,Klein C,Seidel G

    更新日期：2007-10-01 00:00:00

  • The major impact of freezing of gait on quality of life in Parkinson's disease.

    abstract：:Freezing of gait (FOG) is a disabling motor symptom experienced by a large proportion of patients with Parkinson's disease (PD). While it is known that FOG contributes to lower health-related quality of life (HRQoL), previous studies have not accounted for other important factors when measuring the specific impact of ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7524-3

    authors： Walton CC,Shine JM,Hall JM,O'Callaghan C,Mowszowski L,Gilat M,Szeto JY,Naismith SL,Lewis SJ

    更新日期：2015-01-01 00:00:00

  • Small fibre function in primary autonomic failure.

    abstract：:A case of primary autonomic failure (AF) with uncomplicated Parkinson's disease is presented with clinical and neurophysiological data. Special emphasis is placed on new methods of examining impairment of unmyelinated sympathetic and afferent C-fibres. Sympathetic vasoconstrictor responses in the skin induced by deep ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00869769

    authors： Baron R,Feldmann R,Lindner V

    更新日期：1993-12-01 00:00:00

  • Uric acid in relapsing-remitting multiple sclerosis: a 2-year longitudinal study.

    abstract：:Uric acid (UA) is reduced in multiple sclerosis (MS), and possibly relates to MS outcomes, with lower UA levels in subjects experiencing a relapse or presenting higher disability scores. The present retrospective longitudinal study evaluated UA variations in MS, in relation to clinical relapses, disability progression...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-015-7666-y

    authors： Moccia M,Lanzillo R,Costabile T,Russo C,Carotenuto A,Sasso G,Postiglione E,De Luca Picione C,Vastola M,Maniscalco GT,Palladino R,Brescia Morra V

    更新日期：2015-01-01 00:00:00

  • A short scale for evaluation of neuropsychiatric disorders in Parkinson's disease: first psychometric approach.

    abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-012-6490-x

    authors： Martinez-Martin P,Frades-Payo B,Agüera-Ortiz L,Ayuga-Martinez A

    更新日期：2012-11-01 00:00:00

  • Hereditary neuropathy with liability to pressure palsies.

    abstract：:Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-019-09319-8

    authors： Attarian S,Fatehi F,Rajabally YA,Pareyson D

    更新日期：2020-08-01 00:00:00

  • The dynamics of multiple sclerosis. The Charcot Lecture.

    abstract：:The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...

    journal_title：Journal of neurology

    pub_type： 传,历史文章,杂志文章

    doi：10.1007/BF00838443

    authors： McDonald WI

    更新日期：1993-01-01 00:00:00

  • Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study.

    abstract：:The objective of this study was to assess the effect of secukinumab, a monoclonal antibody that inhibits interleukin (IL)-17A, on number of new active brain magnetic resonance imaging (MRI) lesions in subjects with relapsing-remitting multiple sclerosis (MS). Subjects (N = 73) were randomized 1:1 to secukinumab 10 mg/...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00415-016-8128-x

    authors： Havrdová E,Belova A,Goloborodko A,Tisserant A,Wright A,Wallstroem E,Garren H,Maguire RP,Johns DR

    更新日期：2016-07-01 00:00:00

  • Practically applicable nerve ultrasound models for the diagnosis of axonal and demyelinating hereditary motor and sensory neuropathies (HMSN).

    abstract：PURPOSE:To develop specific diagnostic ultrasound (US) models for hereditary motor and sensory neuropathies (HMSN) in patients with primarily demyelinating or axonal polyneuropathies (PNP) according to standard nerve conduction studies (NCS) criteria. METHODS:Single-centre, examiner-blinded cross-sectional study in ac...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-017-8687-5

    authors： Loewenbrück KF,Dittrich M,Böhm J,Klingelhöfer J,Baum P,Schäfer J,Reichmann H,Hermann A,Storch A

    更新日期：2018-01-01 00:00:00

  • Retinal hyperaemia-related blood vessel artifacts are relevant to automated OCT layer segmentation.

    abstract：:A frequently observed local measurement artifact with spectral domain OCT is caused by the void signal of the retinal vasculature. This study investigated the effect of suppression of blood vessel artifacts with and without retinal hyperaemia. Spectral domain OCT scans, centred on the optic nerve head, were performed ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7226-2

    authors： Balk LJ,Mayer M,Uitdehaag BM,Petzold A

    更新日期：2014-03-01 00:00:00

  • Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications.

    abstract：INTRODUCTION:Patients with blepharospasm in addition to involuntary contraction of the orbicularis oculi muscle also have non-motor symptoms (psychiatric, sleep, cognitive, and ocular). In this paper, we investigated the relationship of non-motor with motor symptoms and the total burden of non-motor symptoms in patient...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09484-w

    authors： Ferrazzano G,Berardelli I,Conte A,Baione V,Concolato C,Belvisi D,Fabbrini G,Defazio G,Berardelli A

    更新日期：2019-11-01 00:00:00

  • Silent infarcts in stroke patients: patient characteristics and effect on 2-year outcome.

    abstract：:Although silent infarcts (SIs) are frequent in stroke patients, their clinical significance remains controversial, and their effect on stroke outcome remains unclear. This study evaluated the prevalence of SI on computed tomography, associated factors, and the effect on outcome in stroke patients. We studied 202 conse...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s004150170200

    authors： Corea F,Hénon H,Pasquier F,Leys D,Lille Stroke\/Dementia Study Group.

    更新日期：2001-04-01 00:00:00

  • Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.

    abstract：OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10004-4

    authors： Buchanan SM,Parker TD,Lane CA,Keshavan A,Keuss SE,Lu K,James SN,Murray-Smith H,Wong A,Nicholas J,Cash DM,Malone IB,Coath W,Thomas DL,Sudre C,Fox NC,Richards M,Schott JM

    更新日期：2020-11-01 00:00:00

  • Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients.

    abstract：:The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identi...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6080-3

    authors： Sakushima K,Yabe I,Nakano F,Yoshida K,Tajima Y,Houzen H,Maruo Y,Sasaki H

    更新日期：2011-12-01 00:00:00

  • Short-term and long-term effects of immunoadsorption in refractory chronic inflammatory demyelinating polyneuropathy: a prospective study in 17 patients.

    abstract：OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, autoimmune-inflammatory disease of the peripheral nervous system. Recently, various immunoglobulin G4 (IgG4) type auto-antibodies have been described in patients with CIDP which can effectively be removed by immunoadsorption (IA). Therefore, ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-9082-6

    authors： Dorst J,Ludolph AC,Senel M,Tumani H

    更新日期：2018-12-01 00:00:00

  • Higher frequencies of HLA DQB1*05:01 and anti-glycosphingolipid antibodies in a cluster of severe Guillain-Barré syndrome.

    abstract：:Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj)...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-016-8237-6

    authors： Schirmer L,Worthington V,Solloch U,Loleit V,Grummel V,Lakdawala N,Grant D,Wassmuth R,Schmidt AH,Gebhardt F,Andlauer TF,Sauter J,Berthele A,Lunn MP,Hemmer B

    更新日期：2016-10-01 00:00:00

  • Screening of patients with Huntington's chorea by pneumoencephalography: criteria for decision and probability of error.

    abstract：:The problem of making a decision in case of two clinical hypotheses is treated by the application of the Neyman-Pearson criterion. As an example, a pneumoencephalographic index (frontal horn width divided by septum-caudate distance) of two different diseases, Huntington's chorea and Parkinsonism, is analyzed. As the a...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314395

    authors： Gath I

    更新日期：1978-10-25 00:00:00

  • Juvenile-onset bulbospinal muscular atrophy with deafness: Vialetta-van Laere syndrome or Madras-type motor neuron disease?

    abstract：:A girl with rapid-onset, bulbospinal muscular atrophy and deafness is described. The patient's mother and brother showed EMG features consistent with subclinical involvement. T is bulbospinal form of spinal muscular atrophy associated with deafness described by Vialetto and van Laere closely resembles the Madras type ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314095

    authors： Summers BA,Swash M,Schwartz MS,Ingram DA

    更新日期：1987-08-01 00:00:00

  • Intravenous thrombolysis for ischemic stroke in the golden hour: propensity-matched analysis from the SITS-EAST registry.

    abstract：:As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset ("golden hour"), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(-)] the "golden hour" by analyzing propensity s...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-017-8461-8

    authors： Tsivgoulis G,Katsanos AH,Kadlecová P,Czlonkowska A,Kobayashi A,Brozman M,Švigelj V,Csiba L,Fekete K,Kõrv J,Demarin V,Vilionskis A,Jatuzis D,Krespi Y,Liantinioti C,Giannopoulos S,Mikulik R

    更新日期：2017-05-01 00:00:00

  • Artistic occupations are associated with a reduced risk of Parkinson's disease.

    abstract：:Parkinson's disease (PD) is preceded by a premotor phase of unknown duration. Dopaminergic degeneration during this phase may lead to subtle cognitive and behavioural changes, such as decreased novelty seeking. Consequently, premotor subjects might be most comfortable in jobs that do not require optimal dopamine level...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-015-7828-y

    authors： Haaxma CA,Borm GF,van der Linden D,Kappelle AC,Bloem BR

    更新日期：2015-09-01 00:00:00

  • Hereditary spastic paraplegia caused by the novel mutation 1047insC in the SPG7 gene.

    abstract：:Spastic paraplegia type 7 (SPG7) is an autosomal recessive form of hereditary spastic paraparesis (ARHSP) caused by mutations in paraplegin, a subunit of an ATP-dependent AAA-protease located within the inner mitochondrial membrane. We have identified a novel paraplegin mutation, c.1047insC, in a non-consanguineous No...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-008-0858-y

    authors： Tzoulis C,Denora PS,Santorelli FM,Bindoff LA

    更新日期：2008-08-01 00:00:00

  • Treatment of amyotrophic lateral sclerosis--what is the next step?

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/BF03161074

    authors： Ludolph AC

    更新日期：2000-12-01 00:00:00

  • The role of the long-duration response to levodopa in Parkinson's disease.

    abstract：:The long-duration response (LDR) to levodopa is an important component of the therapeutic response to the drug in Parkinson's disease (PD). Some characteristics are peculiar: it is independent from peripheral pharmacokinetics of levodopa, but it is dependent on the intervals between doses and on the size of each dose....

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-010-5731-0

    authors： Zappia M,Nicoletti A

    更新日期：2010-11-01 00:00:00

  • Neutrophil-to-lymphocyte ratio: a marker of neuro-inflammation in multiple sclerosis?

    abstract：BACKGROUND:The significance of neutrophil-to-lymphocyte ratio (NLR) has been explored in different diseases. Few studies addressed its role in patients with multiple sclerosis (MS), with promising results regarding its association with disease activity or disability. OBJECTIVES:We aimed at confirming the role of NLR a...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10322-7

    authors： Gelibter S,Pisa M,Croese T,Dalla Costa G,Orrico M,Preziosa P,Sangalli F,Martinelli V,Furlan R,Filippi M

    更新日期：2021-01-03 00:00:00

  • Long-term treatment with dopamine agonists in idiopathic Parkinson's disease.

    abstract：:Long-term treatment studies with any antiparkinsonian drug are rather limited. Especially, double-blind, randomized and multicenter studies do not exist except for some rare exceptions. Nonetheless, such studies are mandatory to prove certain therapy regimens. This overview reports on the comparison between dopamine a...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/pl00007768

    authors： Reichmann H

    更新日期：2000-09-01 00:00:00

  • Clinical features of CIS of the brainstem/cerebellum of the kind seen in MS.

    abstract：:Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-5403-0

    authors： Sastre-Garriga J,Tintoré M,Nos C,Tur C,Río J,Téllez N,Castilló J,Horga A,Perkal H,Comabella M,Rovira A,Montalban X

    更新日期：2010-05-01 00:00:00