Abstract:
:Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate (LBSL) is a rare, autosomal recessive disorder caused by mutations in the gene encoding a mitochondrial aspartyl-tRNA synthetase, DARS2. The disease is characterized by progressive spastic ataxia and magnetic resonance imaging (MRI) shows a highly characteristic leukoencephalopathy with multiple long tract involvement. We describe the clinical and radiological features of two new cases of LBSL and report a novel pathogenic mutation in the DARS2 gene. Both patients had typical clinical and radiological findings, although no elevated lactate was found. The severity of MRI changes did not correlate with clinical course and severity suggesting that, although of highly specific diagnostic value, MRI does not necessarily reflect clinical activity and should not be used to assess disease severity or prognosis in LBSL.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Tzoulis C,Tran GT,Gjerde IO,Aasly J,Neckelmann G,Rydland J,Varga V,Wadel-Andersen P,Bindoff LAdoi
10.1007/s00415-011-6176-9subject
Has Abstractpub_date
2012-02-01 00:00:00pages
292-6issue
2eissn
0340-5354issn
1432-1459journal_volume
259pub_type
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