Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis.

Abstract:

:Cognitive impairment belongs to the core symptoms in MS affecting quality of life, self-esteem, and social as well as occupational functioning. Due to this high impact on patients' well-being efficient treatment concepts are required. Imaging studies on cognition have shown that functional reorganisation takes place spontaneously to compensate for deficits. In mildly to moderately impaired patients these processes may support coping with emerging deficits. However, these compensatory processes seem to be limited as brain activation of cognitively severely impaired patients is characterised by decreased additional recruitment of brain regions. Cognitive rehabilitation concentrates on the question whether induction of brain plasticity is possible for both the support of the spontaneous processes and the initiation of new ones. Combining cognition, brain imaging and cognitive rehabilitation in MS, an intriguing question is whether fMRI can provide further insights into the mechanisms of induced plasticity and serve as objective outcome measures for efficient cognitive intervention.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Penner IK,Opwis K,Kappos L

doi

10.1007/s00415-007-2013-6

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

II53-7

eissn

0340-5354

issn

1432-1459

journal_volume

254 Suppl 2

pub_type

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