Factors associated with employment and expected work retention among persons with multiple sclerosis: findings of a cross-sectional citizen science study.

Abstract:

BACKGROUND:Multiple sclerosis (MS) notably affects adults of working age. For persons with MS (PwMS), being employed enhances their quality of life and it may be regarded as an indicator of overall functioning. Thus, ensuring work participation in PwMS is of general public health interest. OBJECTIVE:To examine relevant socio-demographic, MS-, health- and work-related factors, including psychosocial working conditions, associated with currently working PwMS in Switzerland and their expected work retention. METHODS:Using cross-sectional data of PwMS in the Swiss MS Registry (n = 541, median age = 48 [IQR 40;55]), multivariable logistic regression models were computed. First, currently working PwMS were characterised in comparison with those not currently working. Second, expected work retention, operationalized as subjective judgement "likely to work in the same job in 2 years", was examined within the group of currently working PwMS. RESULTS:The factors age (OR 0.96, 95% CI 0.92-0.99), sex (OR 0.28, 95% CI 0.13-0.60), highest achieved job position (OR 1.21, 95% CI 1.01-1.46), health-related quality of life (HRQoL) (OR 1.02, 95% CI 1.01-1.04) and the number of MS symptoms (OR 0.90, 95% CI 0.82-0.98) were associated with currently working PwMS. Moreover, HRQoL (OR 1.07, 95% CI 1.04-1.10) and psychosocial working conditions, such as job resources (e.g. autonomy, control or social support) (OR 2.83, 95% CI 1.50-5.33) and job demands (e.g. workload, time pressure) (OR 0.41, 95% CI 0.18-0.90) were important factors for expected work retention among this group. CONCLUSIONS:Resourceful psychosocial working conditions are crucial for PwMS to maintain employment. Employers could contribute to work retention among PwMS by creating a work environment with resourceful psychosocial working conditions and providing, for instance, social support.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Lehmann AI,Rodgers S,Kamm CP,Mettler M,Steinemann N,Ajdacic-Gross V,Kaufmann M,Kesselring J,Calabrese P,Salmen A,Gobbi C,Zecca C,Bauer GF,von Wyl V

doi

10.1007/s00415-020-09973-3

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

3069-3082

issue

10

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-020-09973-3

journal_volume

267

pub_type

杂志文章
  • The impact of the initial severity on later outcome: retrospective analysis of a large cohort of botulinum toxin naïve patients with idiopathic cervical dystonia.

    abstract:BACKGROUND:The aim of study was to demonstrate that the first three injections of botulinum neurotoxin type A (BoNT/A) appear to be less effective in botulinum toxin naïve patients with idiopathic cervical dystonia (CD) with mild symptoms and low severity scores (TSUI-scores) at onset of BoNT/A-therapy compared to pati...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10128-7

    authors: Hefter H,Samadzazeh S,Rosenthal D

    更新日期:2021-01-01 00:00:00

  • Glatiramer acetate induces pro-apoptotic mechanisms involving Bcl-2, Bax and Cyt-c in peripheral lymphocytes from multiple sclerosis patients.

    abstract::Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells. We analyzed the mitochondria membrane pro- (Bax) and anti-apoptotic (Bcl- 2) and cytosolic pro-apoptotic (Cyt-c, APAF-1) proteins expres...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0965-y

    authors: Ruggieri M,Avolio C,Scacco S,Pica C,Lia A,Zimatore GB,Papa S,Livrea P,Trojano M

    更新日期:2006-02-01 00:00:00

  • Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit.

    abstract:BACKGROUNDS:Wake-Up Stroke (WUS) patients are generally excluded from thrombolytic therapy (rTPA) due to the unknown time of stroke onset. This study aimed to investigate the effects of rTPA in WUS patients during every day clinical scenarios, by measuring ischemic lesion volume and functional outcomes compared to non-...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09603-7

    authors: Furlanis G,Ajčević M,Buoite Stella A,Cillotto T,Caruso P,Ridolfi M,Cova MA,Naccarato M,Manganotti P

    更新日期:2020-03-01 00:00:00

  • Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory condition.

    abstract:BACKGROUND:Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in s...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-017-8696-4

    authors: Pelz JO,Harms K,Metze M,Michalski D

    更新日期:2018-02-01 00:00:00

  • Prevalence of non-motor symptoms in young-onset versus late-onset Parkinson's disease.

    abstract::Non-motor symptoms (NMS) of Parkinson's disease (PD) have only recently been increasingly recognized for their impact on a patient's quality of life. In this study, we applied the validated, comprehensive self-completed NMS questionnaire for PD (NMS Quest) to 101 patients with young-onset PD (onset between 21 and 45 y...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-012-6600-9

    authors: Spica V,Pekmezović T,Svetel M,Kostić VS

    更新日期:2013-01-01 00:00:00

  • Intrafamilial heterogeneity of movement disorders: report of three cases in one family.

    abstract::We report three members of a single family with an apparently autosomal dominant, nonparoxysmal, hyperkinetic movement disorder with onset in adolescence. The proband, a 56-year-old woman, manifested dystonia, tremor and myoclonus; one of her daughters exhibited myoclonus with tremor, and the other demonstrated myoclo...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s004150050116

    authors: Lossos A,Cohen O,Meiner V,Blumenfeld A,Reches A

    更新日期:1997-07-01 00:00:00

  • Recent advances in Parkinson’s disease genetics.

    abstract::The last 5 years have seen rapid progress in Parkinson’s disease (PD) genetics, with the publication of a series of large-scale genome wide association studies for PD, and evaluation of the roles of the LRRK2 and GBA genes in the aetiology of PD. We are beginning to develop a coherent picture of the interplay of Mende...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-013-7003-2

    authors: Lubbe S,Morris HR

    更新日期:2014-02-01 00:00:00

  • A randomised controlled trial of treatment for idiopathic intracranial hypertension.

    abstract::The cause of idiopathic intracranial hypertension (IIH) remains unknown, and no consensus exists on how patients should be monitored and treated. Acetazolamide is a common treatment but has never been examined in a randomised controlled trial. The objectives of this pilot trial are to prospectively evaluate the use of...

    journal_title:Journal of neurology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00415-010-5861-4

    authors: Ball AK,Howman A,Wheatley K,Burdon MA,Matthews T,Jacks AS,Lawden M,Sivaguru A,Furmston A,Howell S,Sharrack B,Davies MB,Sinclair AJ,Clarke CE

    更新日期:2011-05-01 00:00:00

  • Volume loss in the deep gray matter and thalamic subnuclei: a longitudinal study on disability progression in multiple sclerosis.

    abstract:BACKGROUND:Volume loss in the deep gray matter (DGM) has been reported in patients with multiple sclerosis (MS) already at early stages of the disease and is thought to progress throughout the disease course. OBJECTIVE:To investigate the impact and predictive value of volume loss in DGM and thalamic subnuclei on disab...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09740-4

    authors: Magon S,Tsagkas C,Gaetano L,Patel R,Naegelin Y,Amann M,Parmar K,Papadopoulou A,Wuerfel J,Stippich C,Kappos L,Chakravarty MM,Sprenger T

    更新日期:2020-05-01 00:00:00

  • Perfusion-CT imaging in epileptic seizures.

    abstract:INTRODUCTION:PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE). METHODS:We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-018-9095-1

    authors: Strambo D,Rey V,Rossetti AO,Maeder P,Dunet V,Browaeys P,Michel P

    更新日期:2018-12-01 00:00:00

  • Suppression of immune system genes by methylprednisolone in exacerbations of multiple sclerosis. Preliminary results.

    abstract::Acute relapses of multiple sclerosis (MS) are treated with intravenous methylprednisolone (IVMP), which speeds recovery from exacerbation. It is known that IVMP suppresses the immunological activation which occurs during an acute attack of MS. However, the specific target genes affected by this therapy remain obscure....

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-004-0516-y

    authors: Airla N,Luomala M,Elovaara I,Kettunen E,Knuutila S,Lehtimäki T

    更新日期:2004-10-01 00:00:00

  • Long-term outcome changes after mechanical thrombectomy for anterior circulation acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) improves early clinical outcome in patients with acute ischemic stroke but insights on determinants of long-term outcome after MT treatment are scarce. METHODS:Data from stroke patients with anterior circulation large vessel occlusion of a prospective MT registry (01...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09670-w

    authors: Fuhrer H,Forner L,Pruellage P,Weber S,Beume LA,Schacht H,Egger K,Bardutzky J,Weiller C,Urbach H,Niesen WD,Meckel S

    更新日期:2020-04-01 00:00:00

  • Internuclear ophthalmoplegia plus ataxia indicates a dorsomedial tegmental lesion at the pontomesencephalic junction.

    abstract::Internuclear ophthalmoplegia (INO) indicates a lesion involving the medial longitudinal fasciculus (MLF) that interconnects the abducens nucleus and medial rectus subnucleus of the oculomotor nuclear complex. In fact, rostral-caudal localization value of the INO is often limited except when it accompanies symptoms and...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-016-8088-1

    authors: Lee SU,Kim HJ,Park JJ,Kim JS

    更新日期:2016-05-01 00:00:00

  • Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2 : a whole body highfield MRI study.

    abstract::Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeleta...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0111-5

    authors: Kornblum C,Lutterbey G,Bogdanow M,Kesper K,Schild H,Schröder R,Wattjes MP

    更新日期:2006-06-01 00:00:00

  • Is there a difference in gastric emptying between Parkinson's disease patients under long-term L-dopa therapy with and without motor fluctuations? An analysis using the 13C-acetate breath test.

    abstract::The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-009-5220-5

    authors: Tanaka Y,Kato T,Nishida H,Araki H,Murase M,Nagaki M,Moriwaki H,Inuzuka T

    更新日期:2009-12-01 00:00:00

  • Transcranial direct current stimulation for post-stroke dysphagia: a systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Transcranial direct current stimulation (tDCS) has been investigated as a tool for dysphagia recovery after stroke in several single-center randomized controlled trials (RCT). OBJECTIVE:The aim of this investigation was to quantitatively evaluate the effect of tDCS on dysphagia recovery after a stroke utili...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-10142-9

    authors: Marchina S,Pisegna JM,Massaro JM,Langmore SE,McVey C,Wang J,Kumar S

    更新日期:2021-01-01 00:00:00

  • The neurological update: therapies for cerebellar ataxias in 2020.

    abstract::Cerebellar ataxias (CAs) represent a heterogeneous group of sporadic or inherited disorders. The clinical spectrum of CAs is continuously expanding. Our understanding of the mechanisms leading to the clinical deficits has improved over these last decades, in particular thanks to progress in genetics, neuroimaging and ...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-020-09717-3

    authors: Gandini J,Manto M,Bremova-Ertl T,Feil K,Strupp M

    更新日期:2020-04-01 00:00:00

  • A role for cannabinoids in the treatment of myotonia? Report of compassionate use in a small cohort of patients.

    abstract:BACKGROUND:The symptomatic treatment of myotonia and myalgia in patients with dystrophic and non-dystrophic myotonias is often not satisfactory. Some patients anecdotally report symptoms' relief through consumption of cannabis. METHODS:A combination of cannabidiol and tetrahydrocannabinol (CBD/THC) was prescribed as c...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-019-09593-6

    authors: Montagnese F,Stahl K,Wenninger S,Schoser B

    更新日期:2020-02-01 00:00:00

  • A service development study of the assessment and management of fracture risk in Parkinson's disease.

    abstract::Parkinson's disease (PD) is associated with an increased risk of fragility fracture. FRAX and Qfracture are risk calculators that estimate the 10-year risk of hip and major fractures and guide definitive investigation for osteoporosis using dual X-ray absorptiometry (DEXA) imaging. It is unclear which PD patients shou...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-014-7333-8

    authors: Shribman S,Torsney KM,Noyce AJ,Giovannoni G,Fearnley J,Dobson R

    更新日期:2014-06-01 00:00:00

  • Interplay of cerebral autoregulation and neurovascular coupling evaluated by functional TCD in different orthostatic conditions.

    abstract:BACKGROUND:Adequate cerebral blood flow (CBF) is mainly governed by neurovascular coupling (NC) which adapts local CBF to underlying cortical activity,and cerebral autoregulation (CA)that tends to maintain constant CBF despite changes in arterial blood pressure (BP). Since it was suggested that resistance vessels play ...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0338-1

    authors: Azevedo E,Rosengarten B,Santos R,Freitas J,Kaps M

    更新日期:2007-02-01 00:00:00

  • Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

    abstract:OBJECTIVE:Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lo...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-020-09824-1

    authors: Murley AG,Jones PS,Coyle Gilchrist I,Bowns L,Wiggins J,Tsvetanov KA,Rowe JB

    更新日期:2020-08-01 00:00:00

  • The importance of maintaining effective therapy in multiple sclerosis.

    abstract::The INCOMIN study (INdependent COMparison of INterferons) lends further support to the growing body of evidence that both dose and frequency of interferon beta (IFNbeta) administration are important in the treatment of multiple sclerosis (MS). High-dose, high-frequency IFNbeta (IFNbeta-1b 250 microg eod sc and IFNbeta...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-005-2016-0

    authors: Durelli L,Clerico M

    更新日期:2005-09-01 00:00:00

  • Hereditary neuropathy with liability to pressure palsies.

    abstract::Hereditary neuropathy with liability to pressure palsies (HNPP) is characterized by recurrent sensory and motor neuropathy in individual nerves starting in adolescence or young adulthood, focal conduction abnormalities at entrapment sites on nerve conduction studies, and sausage-like swellings (tomacula) of the myelin...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-019-09319-8

    authors: Attarian S,Fatehi F,Rajabally YA,Pareyson D

    更新日期:2020-08-01 00:00:00

  • PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.

    abstract::A linkage and association of the CD45 (protein-tyrosine phosphatase, receptor-type C) C77G polymorphism and multiple sclerosis (MS) has been found in some studies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the transmission disequil...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-004-0485-1

    authors: Cocco E,Murru MR,Melis C,Schirru L,Solla E,Lai M,Rolesu M,Marrosu MG

    更新日期:2004-09-01 00:00:00

  • Topographic brain mapping of the international cooperative ataxia rating scale. A positron emission tomography study.

    abstract::The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebella...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-006-0310-0

    authors: Wang PS,Liu RS,Yang BH,Soong BW

    更新日期:2007-06-01 00:00:00

  • Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population.

    abstract::We examined the influence of alleles at the HLA loci, previously found to be associated with multiple sclerosis (MS) in Sardinia, on the clinical course of the disease in 835 relapsing (R) and 100 primary progressive (PP) patients. Multivariate analysis was carried out on predisposing 0301 or non-associated DPB1 allel...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-005-0957-y

    authors: Marrosu MG,Cocco E,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Sardu C,Contu P

    更新日期:2006-02-01 00:00:00

  • Devic's neuromyelitis optica: long-term follow-up and serial CSF findings in two cases.

    abstract::Sixteen cerebrospinal fluid (CSF) specimens serially obtained during long-term follow-up of two patients with Devic's neuromyelitis optica (DNO) were compared with 65 CSF samples from patients with multiple sclerosis (MS). By statistical analysis, the CSF profile in DNO was found to differ from that observed in MS, ma...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/BF00314631

    authors: Piccolo G,Franciotta DM,Camana C,Bergamaschi R,Banfi P,Sandrini G,Citterio A

    更新日期:1990-07-01 00:00:00

  • Quantitative muscle MRI and ultrasound for facioscapulohumeral muscular dystrophy: complementary imaging biomarkers.

    abstract:OBJECTIVE:To assess the overlap of and differences between quantitative muscle MRI and ultrasound in characterizing structural changes in leg muscles of facioscapulohumeral muscular dystrophy (FSHD) patients. METHODS:We performed quantitative MRI and quantitative ultrasound of ten leg muscles in 27 FSHD patients and a...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-018-9037-y

    authors: Mul K,Horlings CGC,Vincenten SCC,Voermans NC,van Engelen BGM,van Alfen N

    更新日期:2018-11-01 00:00:00

  • Movement disorder emergencies.

    abstract::Movement disorder emergencies include any movement disorder which evolves over hours to days, in which failure to appropriately diagnose and manage can result in patient morbidity or mortality. It is crucial that doctors recognize these emergencies with accuracy and speed by obtaining the proper history and by being f...

    journal_title:Journal of neurology

    pub_type: 杂志文章,评审

    doi:10.1007/s00415-008-4002-9

    authors: Poston KL,Frucht SJ

    更新日期:2008-08-01 00:00:00

  • Nerve conduction and electromyography studies.

    abstract::Nerve conduction studies (NCS) and electromyography (EMG), often shortened to 'EMGs', are a useful adjunct to clinical examination of the peripheral nervous system and striated skeletal muscle. NCS provide an efficient and rapid method of quantifying nerve conduction velocity (CV) and the amplitude of both sensory ner...

    journal_title:Journal of neurology

    pub_type: 杂志文章

    doi:10.1007/s00415-012-6497-3

    authors: Kane NM,Oware A

    更新日期:2012-07-01 00:00:00