Abstract:
:The aim of the study was to identify the main factors that impact mobility impairment in multiple sclerosis (MS) patients in Italy. Clinicians from a large number of Italian MS centers took part in a Delphi process aimed at obtaining consensus statements among the participants. Large consensus was obtained for statements grouped under the following main MS themes: identification of the most useful scales to evaluate mobility, integration of objective evaluation with patient perceptions, impact of walking impairment on daily life, management of the disabled patient using a rehabilitative and pharmacological approach. The consensus statements developed by a large number of experts may be used as a practical reference tool to help physicians treat MS patients with motor impairment.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Capra R,Battaglia MA,Gaudioso A,Lopes L,Paolicelli D,Paoloni M,Pozzilli C,Santilli V,Solaro C,Trojano Mdoi
10.1007/s00415-013-7230-6subject
Has Abstractpub_date
2014-03-01 00:00:00pages
526-32issue
3eissn
0340-5354issn
1432-1459journal_volume
261pub_type
杂志文章abstract:PURPOSE:Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with 123I-iomazenil in patients with denovo temporal lobe epilepsy (T...
journal_title:Journal of neurology
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abstract::Using a novel trial design, we prospectively examined the effect of intravenous immunoglobulin in seven patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in a double-blind, placebo-controlled cross-over study. We suggest that the commonly used manual muscle testing and Rankin scale are not...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::To clarify the changes of cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials induced by air-conducted sound (ACS) and bone-conducted vibration (BCV) in patients with vestibular neuritis (VN), patients with VN (n = 30) and normal controls (n = 45) underwent recording of cVEMP and oVEMP in respons...
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doi:10.1007/s00415-013-6953-8
更新日期:2013-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
abstract::This review gives an overview of various neuroimmunological diseases in terms of incidence and prevalence rates, age and sex distribution, and the frequency of subtypes, if applicable. The disorders selected for review are inflammatory muscle disorders (polymyositis, dermatomyositis and inclusion body myositis), myast...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-5001-3
更新日期:2006-09-01 00:00:00
abstract::The effect of furosemide (Lasix) therapy on a standardized experimental cerebral edema, induced in rats by applying a cooling stamp to the right side of the skull over the right coronal suture by means of a stereotactic instrument, was examined. The hemispherically separated water and electrolyte contents of the brain...
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更新日期:1979-05-02 00:00:00
abstract::A patient with an infarct limited to the paramedian thalamus and upper mesencephalon on the right side suffered a conjugate upgaze palsy associated with a monocular paresis of downward gaze in the ipsilateral eye (vertical "one-and-a-half" syndrome). This paresis involved tonic and phasic components. Vertical oculocep...
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更新日期:1984-01-01 00:00:00
abstract::Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms and to study the rel...
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-08-01 00:00:00
abstract::Thyronine (T4), triiodothyronine (T3), and reverse-triiodothyronine (rT3) levels were evaluated in cerebrospinal fluid (CSF) and in serum of 12 patients with definite amyotrophic lateral sclerosis (ALS) by specific radioimmunoassays. Circulating microsomal and thyroglobulin antibodies were also evaluated. In all patie...
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更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s004150050584
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The increase in disease-modifying drugs (DMDs) allows individualization of treatment in relapsing multiple sclerosis (RMS); however, the long-term impact of different treatment sequences is not well established. This is particularly relevant for MS patients who may need to postpone more aggressive DMD strate...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-019-09531-6
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABAB receptor antibodies (GABABR-Abs). METHODS:Retrospective clinical study of CSF-confirmed cases of GABABR-Abs encephalitis. RESULTS:We identified 22 patients (4 female) with GABABR-Abs, with a median...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9132-0
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Neuropsychological impairments are major symptoms of autoimmune limbic encephalitis (LE) epilepsy patients. In LE epilepsy patients with an autoimmune response against intracellular antigens as well as in antibody-negative patients, the antibody findings and magnetic resonance imaging pathology correspond poo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10158-1
更新日期:2020-08-20 00:00:00
abstract::Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00873519
更新日期:1994-08-01 00:00:00
abstract::Applying microarray technology to identify new diagnostic and prognostic markers in peripheral blood cells (PBC) after therapeutic intervention opens great perspectives regarding patient subclassification. Three recombinant products of the pleiotropic agent interferon beta (rIFN-beta) are available for disease modifyi...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-008-6010-1
更新日期:2008-12-01 00:00:00
abstract::Atrial fibrillation (AF) is a strong risk factor for first-ever stroke and stroke recurrence. The detection rate is low and detection is often costly and time-consuming. We evaluated the diagnostic yield of an external loop recorder (ELR) in patients with acute ischemic stroke or TIA, and assessed factors that are ass...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7621-3
更新日期:2015-03-01 00:00:00
abstract::Neuropsychological assessment is one of the main fields of activity of clinical neuropsychologists. Goals of this assessment are verification and description of cognitive and affective impairments as the consequence of brain damage. Included are examinations of basal and higher sensory functions, the intellectual prof...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-007-2004-7
更新日期:2007-05-01 00:00:00
abstract::Quality of life is an important issue in the treatment of Parkinson's disease. Both general and disease specific quality of life scales are now being used in interventional trials. In the Sinemet CR First trial, the long-acting preparation was found to be superior to the immediate release preparation in several measur...
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pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7524-3
更新日期:2015-01-01 00:00:00
abstract::Multiple system atrophy (MSA) manifests as a combination of dysautonomia and motor symptoms/signs. However, rare cases presenting with autonomic failures in absence of motor symptoms/signs until their deaths have been reported and are referred to as non-motor MSA. To clarify pathological findings underlying non-motor ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8604-y
更新日期:2017-11-01 00:00:00
abstract::The association of pathology and neurological deficit with quality of life (QoL) in multiple sclerosis (MS) is not fully understood. In this study, magnetic resonance imaging (MRI) measures of pathology--T1 and T2 lesion volume and ratio; active T2 lesion number; global and regional brain volume and atrophy; magnetiza...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6151-5
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is induced by a wide spectrum of mutations such as exon deletions, duplications and small mutations in the dystrophin gene. This is the first study on the mutational spectrum in a cohort of DMD children from India, with an emphasis to compare the mutations in familial and ...
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pub_type: 杂志文章
doi:10.1007/s00415-019-09380-3
更新日期:2019-09-01 00:00:00
abstract::Exercise therapy (ET) can be beneficial in disabled multiple sclerosis (MS) patients. Intermittent transcranial magnetic theta burst stimulation (iTBS) induces long-term excitability changes of the cerebral cortex and may ameliorate spasticity in MS. We investigated whether the combination of iTBS and a program of ET ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00415-011-5924-1
更新日期:2011-07-01 00:00:00
abstract::We present a clinical, neuro-radiological and genetic study on a family with members suffering from an autosomal dominantly inherited syndrome characterised by epilepsy, cerebral calcifications and cysts, bone abnormalities; progressive neuro-cognitive deterioration and paranasal sinusitis. This syndrome shares severa...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7393-9
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:A study of cognitive, psychological and social aspects in benign multiple sclerosis (MS). Methods One hundred and sixty three patients with benign MS (defined as disease duration > or = 15 years and Expanded Disability Status Scale (EDSS) score < or = 3.0 ) underwent neuropsychological testing on the Rao's B...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0161-8
更新日期:2006-08-01 00:00:00
abstract::Moderate unilateral cerebral ischemia was produced by microembolism in 24 adult cats. Two million plastic microspheres with a diameter of 15 +/- 5 microns were injected into the left common carotid artery via the lingual artery. The physiological and metabolic responses to embolism were accessed by electrocorticograp...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313342
更新日期:1980-01-01 00:00:00
abstract::We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00900501
更新日期:1996-06-01 00:00:00
abstract::Myotonic Dystrophy Type 1 (DM1) and 2 (DM2) present with distinct though overlapping clinical phenotypes. Comparative imaging data on skeletal muscle involvement are not at present available. We used the novel technique of whole body 3.0 Tesla (T) Magnetic Resonance Imaging (MRI) to further characterize musculoskeleta...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0111-5
更新日期:2006-06-01 00:00:00