Abstract:
:Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literature search produced 55 publications (3 randomised controlled trials, 3 interventional studies, 11 observational studies, 2 case studies, 35 reviews, 1 guideline) all unanimously favouring the use of BT therapy for MS spasticity. There is no reason to believe that BT should be less effective and safe in MS spasticity than it is in stroke spasticity. Recommendations include an update of the current prevalence of MS spasticity and its clinical features according to classifications used in movement disorders. Immunological data on MS patients already treated should be analysed with respect to frequencies of MS relapses and BT antibody formation. Registration authorities should expand registration of BT therapy for spasticity regardless of its aetiology. MS specialists should consider BT therapy for symptomatic treatment of spasticity.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Dressler D,Bhidayasiri R,Bohlega S,Chahidi A,Chung TM,Ebke M,Jacinto LJ,Kaji R,Koçer S,Kanovsky P,Micheli F,Orlova O,Paus S,Pirtosek Z,Relja M,Rosales RL,Sagástegui-Rodríguez JA,Schoenle PW,Shahidi GA,Timerbaeva S,doi
10.1007/s00415-016-8304-zsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
112-120issue
1eissn
0340-5354issn
1432-1459pii
10.1007/s00415-016-8304-zjournal_volume
264pub_type
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