Intrathecal synthesis of specific IgG in syphilitic patients with human immunodeficiency virus 1 infection.

Abstract:

:Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units per milligram of total IgG were estimated in serum and cerebrospinal fluid (CSF) of 13 patients infected with both agents. Synthesis of anti-treponemal IgG in the central nervous system (CNS) was shown in three and of anti-HIV-1 IgG in nine patients with neurological disorders. It is concluded that a differentiation of local IgG immune response in the CNS to one or both infectious agents is possible.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Müller F,Moskophidis M,Schmitz H

doi

10.1007/BF00314359

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

252-3

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

235

pub_type

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