当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study.

Effect of levodopa on handwriting tasks of different complexity in Parkinson's disease: a kinematic study.

Abstract：

:Levodopa treatment does improve Parkinson's disease (PD) dysgraphia, but previous research is not in agreement about which aspects are most responsive. This study investigated the effect of levodopa on the kinematics of writing. Twenty-four patients with PD of less than 10 years duration and 25 age-matched controls were recruited. A practically defined off state method was used to assess the levodopa motor response, measured on the Unified Parkinson's Disease Rating Scale Part III. The kinematic features for six handwriting tasks involving different levels of complexity were recorded from PD patients in off and on states and from the control group. Levodopa is effective for simple writing activities involving repetition of letters, denoting improved fine motor control. But the same benefit was not seen for copying a sentence and a written category fluency test, tasks that carry memory and cognitive loads. We also found significant differences in kinematic features between control participants and PD patients, for all tasks and in both on and off states. Serial testing of handwriting in patients known to be at risk for developing PD might prove to be an effective biomarker for cell loss in the substantia nigra and the associated dopamine deficiency. We recommend using a panel of writing tasks including sentence copying and memory dependence. Dual-task effects may make these activities more sensitive to early motor deficits, while their weaker levodopa responsiveness would cause them to be more stable indicators of motor progression once symptomatic treatment has been commenced.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Zham P,Kumar D,Viswanthan R,Wong K,Nagao KJ,Arjunan SP,Raghav S,Kempster P

doi

10.1007/s00415-019-09268-2

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

1376-1382

issue

6

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-019-09268-2

journal_volume

266

pub_type

杂志文章

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Levels of HVA, 5-HIAA, and MHPG in the CSF of vascular parkinsonism compared to Parkinson's disease and controls.

    abstract：:The neurochemical abnormalities underlying vascular parkinsonism (VP) have not been well characterised. A better understanding may help to optimize pharmacological interventions. Since VP patients generally have a poorer response to l-Dopa than Parkinson's disease (PD) patients, we investigated whether levels of relev...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7126-5

    authors： Herbert MK,Kuiperij H,Bloem BR,Verbeek MM

    更新日期：2013-12-01 00:00:00

  • Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report.

    abstract：:Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequenc...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-006-0486-3

    authors： Hartung HP,Polman C,Bertolotto A,Deisenhammer F,Giovannoni G,Havrdova E,Hemmer B,Hillert J,Kappos L,Kieseier B,Killestein J,Malcus C,Comabella M,Pachner A,Schellekens H,Sellebjerg F,Selmaj K,Sorensen PS

    更新日期：2007-07-01 00:00:00

  • Diagnosis of asymptomatic natalizumab-associated PML: are we between a rock and a hard place?

    abstract：:The diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients in an asymptomatic stage is crucial since it is associated with better clinical outcome measures. Current diagnostic criteria on PML diagnosis in asymptomatic patients require the detection of JC vir...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7336-5

    authors： Wattjes MP,Vennegoor A,Mostert J,van Oosten BW,Barkhof F,Killestein J

    更新日期：2014-06-01 00:00:00

  • Juvenile-onset bulbospinal muscular atrophy with deafness: Vialetta-van Laere syndrome or Madras-type motor neuron disease?

    abstract：:A girl with rapid-onset, bulbospinal muscular atrophy and deafness is described. The patient's mother and brother showed EMG features consistent with subclinical involvement. T is bulbospinal form of spinal muscular atrophy associated with deafness described by Vialetto and van Laere closely resembles the Madras type ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314095

    authors： Summers BA,Swash M,Schwartz MS,Ingram DA

    更新日期：1987-08-01 00:00:00

  • The R495W mutation in SPG3A causes spastic paraplegia associated with axonal neuropathy.

    abstract：:Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q. The encoded protein, atlastin, is a putative member of the dynamin superfamily of large GTPases involved in cellular trafficking patterns. We report a new atlastin mutation causing s...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0768-1

    authors： Scarano V,Mancini P,Criscuolo C,De Michele G,Rinaldi C,Tucci T,Tessa A,Santorelli FM,Perretti A,Santoro L,Filla A

    更新日期：2005-08-01 00:00:00

  • Patient reported outcome measures (PROMs) in amyotrophic lateral sclerosis.

    abstract：OBJECTIVE:Patient reported outcome measures (PROMs) can provide researchers with a direct view of patients' experiences. They are becoming increasingly important tools for evaluating clinical care and research outcomes. There has been little data on the application of PROMs to amyotrophic lateral sclerosis (ALS) care. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-09774-8

    authors： De Marchi F,Berry JD,Chan J,Caldwell S,Ellrodt A,Scalia J,Burke K,Fang T,Clark Sisodia R,Schwamm LH,Moura LMVR,Paganoni S

    更新日期：2020-06-01 00:00:00

  • Low prevalence of ataxic polyneuropathy in a community with high exposure to cyanide from cassava foods.

    abstract：INTRODUCTION:Ataxic polyneuropathy, which occurs in endemic form in an area in southwest Nigeria, is attributed to exposure to cyanide from cassava foods. Exposure to cyanide from cassava is, however, not exclusive to this endemic area. In this study, the occurrence of ataxic polyneuropathy was compared in two communit...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-002-0779-0

    authors： Oluwole OS,Onabolu AO,Cotgreave IA,Rosling H,Persson A,Link H

    更新日期：2002-08-01 00:00:00

  • Musical hallucinations in a musician.

    abstract：:The experience of music is difficult to study objectively. Here we describe a detailed analysis of musical hallucinations developing after a probable brainstem stroke in an 83 year old musician who was able to describe and notate the hallucinations. The hallucinations comprised simple, repetitive melodic and rhythmic ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-006-0167-2

    authors： Warren JD,Schott GD

    更新日期：2006-08-01 00:00:00

  • Auditory function in individuals within Leber's hereditary optic neuropathy pedigrees.

    abstract：:The aims of this study are to investigate whether auditory dysfunction is part of the spectrum of neurological abnormalities associated with Leber's hereditary optic neuropathy (LHON) and to determine the perceptual consequences of auditory neuropathy (AN) in affected listeners. Forty-eight subjects confirmed by genet...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6230-7

    authors： Rance G,Kearns LS,Tan J,Gravina A,Rosenfeld L,Henley L,Carew P,Graydon K,O'Hare F,Mackey DA

    更新日期：2012-03-01 00:00:00

  • Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: a comparative evaluation by IgG-index and isoelectric focusing.

    abstract：:Intrathecal IgG synthesis has been investigated by determining the IgG index and by isoelectric focusing in 30 cases of definite multiple sclerosis, in 15 cases of probable multiple sclerosis and in 128 patients affected by other neurological diseases. The blood-brain barrier function was evaluated at the same time by...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314641

    authors： Poloni M,Rocchelli B,Scelsi R,Pinelli P

    更新日期：1979-10-01 00:00:00

  • Motor dysfunction in HIV-infected patients without clinically detectable central-nervous deficit.

    abstract：:Motor tests were performed in 50 HIV-infected patients in all stages according to the current CDC classification, but without any clinically evident central nervous system deficit, and the results compared with an age-matched control group. Patients were excluded from the study if there was alcohol or drug abuse, feve...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00315660

    authors： Arendt G,Hefter H,Elsing C,Strohmeyer G,Freund HJ

    更新日期：1990-10-01 00:00:00

  • Palliative medicine training for physicians.

    abstract：:In recent years, it has been widely recognised that modern doctors are not receiving the training they need to provide appropriate and effective palliative care. Deficiencies in care have been reported in several formal studies and, anecdotally, in many professional and popular lay publications. Doctors themselves hav...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/pl00007722

    authors： Doyle D

    更新日期：1997-10-01 00:00:00

  • Double-blind crossover study with dolasetron mesilate, a 5-HT3 receptor antagonist in cerebellar syndrome secondary to multiple sclerosis.

    abstract：:Cerebellar syndrome is one of the most disabling developments in multiple sclerosis (MS). In neurodegenerative disorders, cerebellar syndrome is thought to be related to a neurochemical deficit of 5-hydroxytryptamine (5-HT). Previous studies found that a levorotatory form of 5-hydroxytryptophan, a 5-HT precursor, and ...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00415-003-0176-3

    authors： Monaca-Charley C,Stojkovic T,Duhamel A,De Seze J,Ferriby D,Vermersch P

    更新日期：2003-10-01 00:00:00

  • Screening performance of abbreviated versions of the UPSIT smell test.

    abstract：BACKGROUND:Hyposmia can develop with age and in neurodegenerative conditions, including Parkinson's disease (PD). The University of Pennsylvania Smell Identification Test (UPSIT) is a 40-item smell test widely used for assessing hyposmia. However, in a number of situations, such as identifying hyposmic individuals in l...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09340-x

    authors： Joseph T,Auger SD,Peress L,Rack D,Cuzick J,Giovannoni G,Lees A,Schrag AE,Noyce AJ

    更新日期：2019-08-01 00:00:00

  • Relapse frequency in transitioning from natalizumab to dimethyl fumarate: assessment of risk factors.

    abstract：:Risk of relapse after natalizumab (NAT) cessation and switch to dimethyl fumarate (DMF) is unknown. The objective of this paper is to identify the risk and associated risk factors for relapse after switching from NAT to DMF in relapsing-remitting multiple sclerosis. Patients (n = 30) were treated with NAT for ≥12 mont...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-016-8162-8

    authors： Zurawski J,Flinn A,Sklover L,Sloane JA

    更新日期：2016-08-01 00:00:00

  • CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction.

    abstract：:To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction w...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314282

    authors： Kobari M,Ishihara N,Yunoki K

    更新日期：1987-06-01 00:00:00

  • Mastication-induced vertigo and nystagmus.

    abstract：:Even though trigeminovestibular connections are well established in animals, mastication-induced dizziness has been described only as a vascular steal phenomenon in humans. We determined induction or modulation of nystagmus in two index patients with mastication-induced vertigo, 12 normal controls, and 52 additional p...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7221-7

    authors： Park SH,Kim HJ,Kim JS,Koo JW,Oh SW,Kim DU,Kim JT,Welgampola M,Deriu F

    更新日期：2014-03-01 00:00:00

  • Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients.

    abstract：:Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-na...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6407-0

    authors： Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone P

    更新日期：2012-09-01 00:00:00

  • Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A.

    abstract：OBJECTIVE:To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A. METHODS:Short-term power spectral analysis of heart rate and systolic blood pressure variabilit...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-008-0753-6

    authors： Tiple D,Strano S,Colosimo C,Fabbrini G,Calcagnini G,Prencipe M,Berardelli A

    更新日期：2008-06-01 00:00:00

  • Dissecting aneurysm of intracranial vertebral artery: case report and review of literature.

    abstract：:A spontaneous dissecting aneurysm of the intracranial portion of the dominant right vertebral artery presented as massive subarachnoid hemorrhage, excruciating headache, and respiratory arrest in a 57-year-old white man with a history of systemic hypertension. He died on the 3rd day. Postmortem examination revealed a ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313594

    authors： Manz HJ,Luessenhop AJ

    更新日期：1983-01-01 00:00:00

  • Aphasia outcome: the interactions between initial severity, lesion size and location.

    abstract：OBJECTIVES:The outcome of aphasia at 3 months is variable in patients with moderate/severe stroke. The aim was to predict 3-month aphasia outcome using prediction models including initial severity in addition to the interaction between lesion size and location at the acute phase. METHODS:Patients with post-stroke apha...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09259-3

    authors： Benghanem S,Rosso C,Arbizu C,Moulton E,Dormont D,Leger A,Pires C,Samson Y

    更新日期：2019-06-01 00:00:00

  • Measurement of the effect of a bolus dose of intrathecal baclofen by continuous measurement of force under fibreglass casts.

    abstract：:Continuous intrathecal administration of baclofen with implanted programmable pump systems is recommended in the treatment of severe spasticity of cerebral origin. Prior to pump implantation, a baclofen bolus test (BBT) is used to assess the effectiveness of intrathecal baclofen using the modified Ashworth Scale (MAS)...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-002-0825-y

    authors： Pohl M,Rockstroh G,Rückriem S,Mehrholz J,Mrass G,Pause M

    更新日期：2002-09-01 00:00:00

  • Magnesium deficiency as a cause of acute intractable seizures.

    abstract：:Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are prese...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00319737

    authors： Nuytten D,Van Hees J,Meulemans A,Carton H

    更新日期：1991-08-01 00:00:00

  • Patterns of cortical activity differ in ALS patients with limb and/or bulbar involvement depending on motor tasks.

    abstract：:Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involve...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5842-7

    authors： Kollewe K,Münte TF,Samii A,Dengler R,Petri S,Mohammadi B

    更新日期：2011-05-01 00:00:00

  • Development and pilot phase of a European MS register.

    abstract：:The MS-ID (Multiple Sclerosis Information Dividend) project was initiated by the European Multiple Sclerosis Platform (EMSP) in 2007 in order to identify and address major inequalities of MS treatment and care and thus eliminate disparities across the EU. One major approach to reach these goals in the longer term is t...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-010-5578-4

    authors： Flachenecker P,Khil L,Bergmann S,Kowalewski M,Pascu I,Pérez-Miralles F,Sastre-Garriga J,Zwingers T

    更新日期：2010-10-01 00:00:00

  • Frequency of nocturnal sudden death in patients with multiple system atrophy.

    abstract：:Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA. During the 5-year observation period, 10 of 45 patients with probable MSA died. The ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-008-0941-4

    authors： Shimohata T,Ozawa T,Nakayama H,Tomita M,Shinoda H,Nishizawa M

    更新日期：2008-10-01 00:00:00

  • Acupuncture versus propranolol in migraine prophylaxis: an indirect treatment comparison meta-analysis.

    abstract：BACKGROUND:Propranolol is recommended as first-line treatment for preventing migraine attacks; acupuncture has not been compared with propranolol in a head-to-head trial. OBJECTIVE:To compare acupuncture with propranolol using indirect treatment comparison meta-analysis. METHOD:We searched MEDLINE, EMBASE, and Cochra...

    journal_title：Journal of neurology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00415-019-09510-x

    authors： Chen YY,Li J,Chen M,Yue L,She TW,Zheng H

    更新日期：2020-01-01 00:00:00

  • A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis.

    abstract：:Thinning of the retinal nerve fiber layer (RNFL) of clinically unaffected eyes is seen in patients with multiple sclerosis (MS). It is uncertain when this thinning occurs, and whether ongoing RNFL loss can be measured over time with optical coherence tomography (OCT). Using time-domain OCT, we studied 34 patients with...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5467-x

    authors： Henderson AP,Trip SA,Schlottmann PG,Altmann DR,Garway-Heath DF,Plant GT,Miller DH

    更新日期：2010-07-01 00:00:00

  • Efficacy and safety of mechanical thrombectomy for M2 segment of middle cerebral artery: a systematic review and meta-analysis.

    abstract：BACKGROUND AND PURPOSE:The efficacy and safety of mechanical thrombectomy (MT) for M2 segment occlusion of middle cerebral artery in patients with acute ischemic stroke (AIS) was investigated. METHODS:We searched PubMed and EMBASE from inception to 16 April 2019 for relevant studies, calculated the pool relative risks...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-020-09710-w

    authors： Wang J,Qian J,Fan L,Wang Y

    更新日期：2020-01-22 00:00:00

  • "Vestibular migraine": effects of prophylactic therapy with various drugs. A retrospective study.

    abstract：:Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-009-0111-3

    authors： Baier B,Winkenwerder E,Dieterich M

    更新日期：2009-03-01 00:00:00