Abstract:
:Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequency of administration, level of dose and formulation of IFNbeta. Taken together, the evidence that NAb status reduces clinical efficacy in MS patients is strong. Standardised assays for NAbs are lacking, and titres vary over time. NAb testing is a critical component of care for MS patients because it provides information on one of the most important factors determining clinical responsiveness to IFNbeta therapy. This expert panel report attempts to move the field towards resolution of the remaining issues and considers several aspects of NAbs, including their clinical relevance, factors influencing immunogenicity, assays to quantify NAbs and the definition of clinically relevant titres.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Hartung HP,Polman C,Bertolotto A,Deisenhammer F,Giovannoni G,Havrdova E,Hemmer B,Hillert J,Kappos L,Kieseier B,Killestein J,Malcus C,Comabella M,Pachner A,Schellekens H,Sellebjerg F,Selmaj K,Sorensen PSdoi
10.1007/s00415-006-0486-3subject
Has Abstractpub_date
2007-07-01 00:00:00pages
827-37issue
7eissn
0340-5354issn
1432-1459journal_volume
254pub_type
杂志文章,评审abstract::We measured changes in brain magnetization transfer ratio (MTR) as a potential indicator of myelin density in brain tissue of patients with relapsing-remitting multiple sclerosis (RRMS) treated with delayed-release dimethyl fumarate (DMF) in the Phase 3 DEFINE study. DEFINE was a randomized, double-blind, placebo-cont...
journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-014-7504-7
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE). METHODS:We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9095-1
更新日期:2018-12-01 00:00:00
abstract::The diagnosis and management of lesions of the brachial roots and of the brachial plexus is improved by appropriate investigation, both in acute and chronic disorders. The choice of investigation should be determined by the clinical problem. Since they are relatively non-invasive, electrophysiological investigations a...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00314416
更新日期:1986-06-01 00:00:00
abstract::An immunohistochemical study using the mirror-image technique was performed in order to establish whether amyloid P component is involved in the mechanism of deposition of amyloid fibrils in senile plaques (SPs) in Alzheimer-type dementia (ATD). Ninety percent of beta/A4 protein-immunoreactive SPs were also stained by...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00868345
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy. METHODS:All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years. RESULTS:Five patients with intracrani...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0065-7
更新日期:2006-05-01 00:00:00
abstract::Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of progressive heterotopic ossification (HO) caused by a recurrent activating mutation of ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. FOP is characterized by progressive HO, which is associated with inflammation in the setting o...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6563-x
更新日期:2012-12-01 00:00:00
abstract::There have been few reports concerning the characteristics of cerebral infarction associated with migraine (CIAM), and especially about the subsequent fate of these patients. We studied 14 patients (9 female) with CIAM. In all these patients the onset of cerebral infarction was accompanied by a unilateral throbbing he...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00886872
更新日期:1996-07-01 00:00:00
abstract::Little is known about the pattern of subacute cognitive domain impairments after ischaemic stroke, nor the temporal evolution of such impairments. Our objective was to investigate the pattern of cognitive impairment in different neuropsychological domains up to a year after ischaemic stroke. We included prospectively ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6625-0
更新日期:2013-01-01 00:00:00
abstract::This review summarizes topical papers from the fields of neuro-ophthalmology and neuro-otology published from August 2013 to February 2015. The main findings are: (1) diagnostic criteria for pseudotumor cerebri have been updated, and the Idiopathic Intracranial Hypertension Treatment Trial evaluated the efficacy of ac...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-015-7825-1
更新日期:2015-12-01 00:00:00
abstract::Rituximab, a monoclonal antibody to CD20, is an effective treatment for relapsing remitting multiple sclerosis (MS) reducing relapse rate by at least 50% over time. Although the mechanism for this clinical benefit is unclear, rituximab depletes circulating B cells, which can perform antigen presentation and stimulatio...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8996-3
更新日期:2018-10-01 00:00:00
abstract::Circulating and cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels represent a reliable indicator of disease activity and axonal damage in different neuroinflammatory conditions. Recently, high CSF NfL levels have been detected in active autoimmune encephalitis, as opposed to significant lower levels aft...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09306-z
更新日期:2019-07-01 00:00:00
abstract::Clinical and experimental investigations have shown that magnesium depletion causes a marked irritability of the nervous system, eventually resulting in epileptic seizures. Although magnesium deficiency as a cause of epilepsy is uncommon, its recognition and correction may prove life-saving. Two case reports are prese...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00319737
更新日期:1991-08-01 00:00:00
abstract::Several studies have reported infection as a possible risk factor for cervical artery dissection (CAD). We retrospectively analyzed several inflammatory parameters of CAD patients with the aim of detecting differences between spontaneous (n = 25) and traumatic (n = 18) CAD. In this case-control study, we observed sign...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0109-z
更新日期:2006-06-01 00:00:00
abstract::The management of high-grade glioma (HGG) has evolved significantly over the last decade. Patients are managed in a multidisciplinary team setting in order to ensure their care is guided by the most current evidenced based treatments. The outcome in patients with HGG, while still poor, has improved in terms of both su...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-013-7032-x
更新日期:2014-04-01 00:00:00
abstract::The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...
journal_title:Journal of neurology
pub_type: 已发布勘误
doi:10.1007/s00415-020-10256-0
更新日期:2020-10-20 00:00:00
abstract::We report two adult Japanese sisters with L-2-hydroxy-glutaric aciduria (acidemia), both of whom were much older (aged 57, 47 years old) than previously reported patients (from neonate to 44 years old), and who presented with differing severity. Magnetic resonance imaging revealed typical subcortical white matter lesi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050367
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Recently, therapeutic attempts to control motor choreatic hyperkinesia of Huntington's disease (HD) by means of pallidal deep brain stimulation (Gp-DBS) were successful. With respect to the clinical effects of Gp-DBS in juvenile hypokinetic-rigid HD (jHD; Westphal variant), only one single-case has been repo...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8880-1
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy and safety of the therapeutic regimen using oral and intravenous L-arginine for pediatric and adult patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). METHODS:In the presence and absence of an ictus of stroke-like episodes within 6...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00415-018-9057-7
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8901-0
更新日期:2018-07-01 00:00:00
abstract::Thirty-seven Japanese autopsy cases with diffuse Lewy body disease (DLBD) were reviewed from a clinicopathological viewpoint. Based on the neuropathological finding of whether or not many concomitant senile plaques (SPs) and/or neurofibrillary tangles (NFTs) are present. DLBD is divided into two forms: a common form a...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00314594
更新日期:1990-06-01 00:00:00
abstract::Acid maltase deficiency is described in non-identical adult twins. The onset of the disease can be traced into late infancy; the clinical picture is one of severe muscular dystrophy; respiratory insuficiency was the cause of death in one case. The autopsy showed the central nervous system, heart and liver to be spared...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313272
更新日期:1976-08-06 00:00:00
abstract::Diffusion tensor imaging (DTI) has become a useful tool for investigating early white matter (WM) abnormalities in motor neuron disease. Furthermore, fiber tracking packages that apply multi-tensorial algorithms, such as q-ball imaging (QBI), have been proposed as alternative approaches to overcome DTI limitations in ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7144-3
更新日期:2014-01-01 00:00:00
abstract::Stroke patients with "pusher syndrome" show severe misperception of their own upright body orientation although visual-vestibular processing is almost intact. This dissociation argues for a second graviceptive system in humans for the perception of body orientation. Recent studies revealed that the posterior thalamus ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0025-7
更新日期:2006-04-01 00:00:00
abstract::Stroke in young adults is not a rare entity, and often provides difficult management decisions for neurologists. The knowledge gained from stroke in older adults does not transfer easily to this younger group given the different causes of stroke observed. Cardiac causes of stroke are common in this group, but often co...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-010-5647-8
更新日期:2010-11-01 00:00:00
abstract::The APOE*4 allele of the apolipoprotein E gene increases the risk of Alzheimer's disease (AD), but whether it also affects the course of the disease is controversial. However, all studies on this issue until now have been based on patients at various stages of disease. In the present population-based study, 97 patient...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050351
更新日期:1999-04-01 00:00:00
abstract::Bilateral paramedian thalamic infarctions are usually associated with impaired consciousness, oculomotor disturbances and neuropsychological changes. A 44-year-old healthy woman presented with amaurosis fugax of the right eye immediately after a Valsalva maneuver. Neurological examination, in particular visual acuity,...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5030-9
更新日期:2009-06-01 00:00:00
abstract::Patients in a minimally conscious state (MCS) show restricted signs of awareness but are unable to communicate. We assessed cerebral glucose metabolism in MCS patients and tested the hypothesis that this entity can be subcategorized into MCS- (i.e., patients only showing nonreflex behavior such as visual pursuit, loca...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6303-7
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Propranolol is recommended as first-line treatment for preventing migraine attacks; acupuncture has not been compared with propranolol in a head-to-head trial. OBJECTIVE:To compare acupuncture with propranolol using indirect treatment comparison meta-analysis. METHOD:We searched MEDLINE, EMBASE, and Cochra...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析
doi:10.1007/s00415-019-09510-x
更新日期:2020-01-01 00:00:00
abstract::We have performed genetic screening on the skeletal muscle chloride channel gene (CLCN1) in Taiwanese population. A total of four patients with myotonia congenita (MC) together with 106 normal individuals were examined. All 23 exons of the CLCN1 gene were analysed by direct sequencing of PCR products to detect the nuc...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-0383-6
更新日期:2004-06-01 00:00:00
abstract::Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed to describe, among UK participants, what clinical and psycho-social characteristics are associated with QoL. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8512-1
更新日期:2017-06-01 00:00:00