Abstract：
:Rituximab, a monoclonal antibody to CD20, is an effective treatment for relapsing remitting multiple sclerosis (MS) reducing relapse rate by at least 50% over time. Although the mechanism for this clinical benefit is unclear, rituximab depletes circulating B cells, which can perform antigen presentation and stimulation of T cells. Another anti-CD20 drug, ocrelizumab, has recently been FDA approved to treat both relapsing remitting and progressive forms of MS. While long-term effects of ocrelizumab use are essentially unknown, long-term use of rituximab has been associated with the development of progressive multifocal leukoencephalopathy (PML) at an incidence of approximately 1/25,000 in non-MS conditions. Serostatus for JC virus (JCV), the causative agent for PML, is an important risk stratification tool for natalizumab, but its utility in other MS treatments is uncertain. We found that rituximab use was associated with a reduction in JCV antibody index values in MS patients. Reductions in immunoglobulins, IgM in particular, are seen in concert with JCV antibody reductions. Physicians should exercise caution when using JCV antibody indices to assess any risk of PML for patients on rituximab.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Baber U,Bouley A,Egnor E,Sloane JAdoi
10.1007/s00415-018-8996-3subject
Has Abstractpub_date
2018-10-01 00:00:00pages
2342-2345issue
10eissn
0340-5354issn
1432-1459pii
10.1007/s00415-018-8996-3journal_volume
265pub_type
杂志文章abstract：OBJECTIVE:The variability of the severity and regional distribution of pathological process in basal ganglia (BG) and brainstem-cerebellar systems results in clinical heterogeneity and represents the motor subtype of multiple system atrophy (MSA). This study aimed to quantify spatial patterns of multimodal MRI abnormal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8874-z
更新日期：2018-07-01 00:00:00
abstract：:Idiopathic hypereosinophilic syndrome (IHES) is a primary haematological condition characterised by persistent, otherwise unexplained hypereosinophilia sufficient to cause organ damage. Various neurological complications are reported, but very few have mentioned CNS pathology and none has included CNS vasculitis. Our ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7720-9
更新日期：2015-05-01 00:00:00
abstract：:Pompe disease is an autosomal recessive disorder in which deficiency of the lysosomal enzyme acid alpha-glucosidase results in the accumulation of glycogen mostly in muscle tissues. Several reports suggest a higher incidence of intracranial vascular abnormalities (IVAs) in this condition, as well as brain microbleeds ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8601-1
更新日期：2017-10-01 00:00:00
abstract：:Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444014
更新日期：1996-02-01 00:00:00
abstract：:Additional autoimmune diseases in people with multiple sclerosis (MS) and their relatives have been studied many times. Studies have employed different designs, and yielded conflicting results. We performed a systematic review, and calculated overall risk of additional autoimmune diseases in people with MS and their f...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-012-6790-1
更新日期：2013-05-01 00:00:00
abstract：:Spinocerebellar ataxia (SCA) type 7 is an autosomal dominant disorder characterized by neural loss, mainly in the cerebellum and regions of the brainstem and particularly the inferior olivary complex. This neurodegeneration disease is associated with expansion of unstable CAG repeats within the 5'-translated region of...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150070131
更新日期：2000-08-01 00:00:00
abstract：:The aim of the study was to identify the main factors that impact mobility impairment in multiple sclerosis (MS) patients in Italy. Clinicians from a large number of Italian MS centers took part in a Delphi process aimed at obtaining consensus statements among the participants. Large consensus was obtained for stateme...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7230-6
更新日期：2014-03-01 00:00:00
abstract：:Optic neuritis usually presents with rapid and gradual loss of vision that is either complete or incomplete, and typically associated with retro-orbital pain. To our knowledge there have been no documented reports of optic neuritis presenting with multiple episodes of amaurosis fugax, the sudden and transient loss of ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5302-4
更新日期：2009-12-01 00:00:00
abstract：:Mutations in the mitofusin 2 (MFN2) gene are a major cause of primary axonal Charcot- Marie-Tooth (CMT) neuropathy. This study aims at further characterization of cerebral white matter alterations observed in patients with MFN2 mutations. Molecular genetic, magnetic resonance imaging (MRI), magnetic resonance spectros...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0847-1
更新日期：2008-07-01 00:00:00
abstract：:It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-con...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00415-003-1097-x
更新日期：2003-07-01 00:00:00
abstract：:We report two cases of unilateral spatial neglect associated with an isolated right frontal lobe lesion. Case 1 was a 59-year-old, right-handed man, who developed a left hemiplegia, disorientation, and frontal lobe neglect associated with a haemorrhagic contusion following a head injury. Case 2 was a 55-year-old, righ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00866909
更新日期：1995-10-01 00:00:00
abstract：:We present evidence that Willy Loman, the protagonist of Arthur Miller's play "Death of a Salesman", meets current diagnostic criteria for probable dementia with Lewy bodies. In particular, he presents with attentional deficits and executive dysfunction (with additional subtle visuoperceptual deficits) in addition to ...
journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-019-09343-8
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The increase in disease-modifying drugs (DMDs) allows individualization of treatment in relapsing multiple sclerosis (RMS); however, the long-term impact of different treatment sequences is not well established. This is particularly relevant for MS patients who may need to postpone more aggressive DMD strate...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-019-09531-6
更新日期：2019-12-01 00:00:00
abstract：:Sexuality in patients with amyotrophic lateral sclerosis (ALS) has received little attention so far. Although sexual function is not directly affected by the disease process, several patients have reported problems within their sexual relationship. We performed a questionnaire survey to ascertain the extent and clinic...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0351-1
更新日期：2004-04-01 00:00:00
abstract：:Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-015-7963-5
更新日期：2016-04-01 00:00:00
abstract：:During the last few years, deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as a promising therapy, alleviating major motor symptoms of Parkinson's disease (PD). However, in times of growing budgetary limitations, medical decisions are no longer merely based on clinical efficacy, but also on c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0640-3
更新日期：2005-02-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09192-5
更新日期：2019-03-01 00:00:00
abstract：OBJECTIVE:We characterised the clinical and neuro-otological characteristics of patients with Susac syndrome. METHODS:The medical records of 30 patients with Susac syndrome were reviewed for details of their clinical presentation and course, neuro-otological symptoms, investigation results including audiology and vest...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-10086-0
更新日期：2020-12-01 00:00:00
abstract：:The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5543-2
更新日期：2010-09-01 00:00:00
abstract：:To define the incidence and type of neurological complications and associated factors, we reviewed 41 consecutive patients who had 45 procedures for liver transplantation. Encephalopathy occurred after 28 procedures (62%) with immediate onset and no significant recovery before death or re-transplantation in 11 (24%), ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170023
更新日期：2001-12-01 00:00:00
abstract：:Facioscapulohumeral muscular dystrophy (FSHD) is the third most common muscular dystrophy and usually follows an autosomal dominant trait. Clinically, FSHD affects facial muscles and proximal upper limb and girdle muscles, but may present with variable clinical phenotypes even within the same family. Most genetically ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5471-1
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Body weight reduction after disease onset is an independent predictor of survival in amyotrophic lateral sclerosis (ALS), but significance of weight variation after diagnosis remains to be established. OBJECTIVE:To investigate weight variation after diagnosis and its prognostic significance in patients with...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09276-2
更新日期：2019-06-01 00:00:00
abstract：:The objective of this study was to investigate cognitive dysfunction in 24-60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-016-8345-3
更新日期：2017-08-01 00:00:00
abstract：:Glucocorticoids are the standard of care for multiple sclerosis (MS) relapses, but the most desirable route of administration is still matter of debate. The aim of the study was to compare the efficacy and safety of oral versus intravenous steroids for treatment of acute relapses in patients with MS. Randomized or qua...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00415-017-8505-0
更新日期：2017-08-01 00:00:00
abstract：:Normal pressure hydrocephalus (NPH) is characterised by gait disturbance, urinary incontinence and dementia. Even though dementia is a cardinal symptom of NPH, there is few data available concerning cognitive functioning. The aim of this observational case-control study was to evaluate the use of neuropsychological (N...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7489-2
更新日期：2014-12-01 00:00:00
abstract：:Stroke patients with "pusher syndrome" show severe misperception of their own upright body orientation although visual-vestibular processing is almost intact. This dissociation argues for a second graviceptive system in humans for the perception of body orientation. Recent studies revealed that the posterior thalamus ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0025-7
更新日期：2006-04-01 00:00:00
abstract：:We examined the effect of bilateral subthalamic nucleus stimulation on levodopa-resistant balance impairment in 14 patients with Parkinson's disease and 18 matched controls. Instability was quantitatively assessed using standardized multidirectional dynamic posturography. Patients were tested after taking a suprathres...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0636-x
更新日期：2008-02-01 00:00:00
abstract：:An immunohistochemical study using the mirror-image technique was performed in order to establish whether amyloid P component is involved in the mechanism of deposition of amyloid fibrils in senile plaques (SPs) in Alzheimer-type dementia (ATD). Ninety percent of beta/A4 protein-immunoreactive SPs were also stained by...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00868345
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8790-2
更新日期：2018-05-01 00:00:00
abstract：:The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5220-5
更新日期：2009-12-01 00:00:00
