Abstract:
:It is well known that neurorehabilitation can reduce disability or improve handicap of people with multiple sclerosis (MS). The aim of this study was to evaluate the effectiveness of a short period (6 weeks) of a tailored, individualised outpatient rehabilitation program in people with progressive MS. A randomised-controlled trial was undertaken in patients with primary and secondary progressive MS referred to the Centro Sclerosi Multipla of Catania. One hundred and eleven patients were assessed at baseline and at 12 weeks with validated measures of disability (Functional Independence Measure (FIM)) and impairment (Expanded Disability Status Scale (EDSS) and Functional Systems Scale). Of the 111, 58 were randomly assigned to the treatment group and 53 to the control group. All patients had been previously trained in a home exercise program. Both groups were well matched for age, sex, disease duration and severity, disability and quality of life (Short Form-36). At the end of 6 weeks patients allocated to the rehabilitation treatment group showed significant improvement in their level of disability compared with the control group,while the level of impairment did not change. Thirty-two patients of the treatment group and four of the control group improved on the FIM by two or more steps at 12 weeks (p<0.0001). An improvement by 1 EDSS step occurred in only two patients of the treatment group and in one patient of the control group. Benefits were maintained for a further six weeks. This study demonstrates that a short outpatient rehabilitation treatment improves disability of MS patients, without changing their impairment and confirms the effectiveness of rehabilitation in people with MS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Patti F,Ciancio MR,Cacopardo M,Reggio E,Fiorilla T,Palermo F,Reggio A,Thompson AJdoi
10.1007/s00415-003-1097-xkeywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
861-6issue
7eissn
0340-5354issn
1432-1459journal_volume
250pub_type
临床试验,杂志文章,随机对照试验abstract::Glucocorticoids are the standard of care for multiple sclerosis (MS) relapses, but the most desirable route of administration is still matter of debate. The aim of the study was to compare the efficacy and safety of oral versus intravenous steroids for treatment of acute relapses in patients with MS. Randomized or qua...
journal_title:Journal of neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00415-017-8505-0
更新日期:2017-08-01 00:00:00
abstract::Fatigue is a common symptom of multiple sclerosis (MS) even in the early phases of the disease, when neurological disability is usually still not present. To investigate the pathophysiology of fatigue we compared neurophysiological (motor evoked potentials of the four limbs, MEPs) and brain magnetic resonance imaging ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150070148
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Multiple sclerosis (MS) notably affects adults of working age. For persons with MS (PwMS), being employed enhances their quality of life and it may be regarded as an indicator of overall functioning. Thus, ensuring work participation in PwMS is of general public health interest. OBJECTIVE:To examine relevan...
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pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
abstract::A case of a patient with hyperinsulinism due to insulinoma associated with neurological and psychiatric disturbances including EEG alterations is reported. The hunger test as well as the i.v. tolbutamid test proved to be of diagnostic importance. In addition, the electroencephalographic studies combined with blood sug...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00329161
更新日期:1976-04-23 00:00:00
abstract::The gut with its variety of microbiota may serve as an etiological origin of diseases. Gut microbes may also play a role in the pathogenesis of diseases beyond their simple nutritional maintenance and support. For example, gut protein aggregation, possibly aided by microbes as well as nasal influences, might be linked...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8588-7
更新日期:2017-09-01 00:00:00
abstract::We describe three patients with a late presentation of congenital muscular torticollis to emphasize that this non-dystonic type of torticollis has to be considered in the differential diagnosis of cervical dystonia, even in adult patients. Surgery is the treatment of choice. Postoperatively, two of our patients had a ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00868411
更新日期:1996-04-01 00:00:00
abstract::Recent genetic studies suggest a Sardinian type of amyotrophic lateral sclerosis (ALS). Thus, ALS incidence, prevalence and survival were investigated in a large population of Sardinians aimed to disclose population-specific patterns and their temporal changes. This is a population-based incidence and prevalence study...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6681-5
更新日期:2013-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-8917-5
更新日期:2018-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09574-9
更新日期:2020-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314395
更新日期:1978-10-25 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-5955-7
更新日期:2011-08-01 00:00:00
abstract::Fatigue is a common and frequently disabling symptom of multiple sclerosis (MS). The aim of this study was to develop the Fatigue index Kliniken Schmieder (FKS) for detecting motor fatigue in patients with MS using kinematic gait analysis. The FKS relies on the chaos theoretical term "attractor", which, if unchanged, ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7415-7
更新日期:2014-09-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-013-7105-x
更新日期:2014-07-01 00:00:00
abstract::This paper summarizes the methods we devised for the treatment of psychosis, orthostatic hypotension, and mood disorders among the various non-motor complications of Parkinson's disease. Psychosis may not manifest when a patient believes in his/her delusions. If left untreated over a prolonged period, however, the del...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-009-5245-9
更新日期:2009-08-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050076
更新日期:1997-04-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313729
更新日期:1982-01-01 00:00:00
abstract::The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-012-6490-x
更新日期:2012-11-01 00:00:00
abstract::Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are the major immune neuropathies. Although a detailed understanding of the pathogenesis of these conditions is not yet available, the multiple effects of IVIg on the immune and inflamm...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-008-3003-z
更新日期:2008-07-01 00:00:00
abstract::Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF02444014
更新日期:1996-02-01 00:00:00
abstract::Somatostatin levels were measured in cerebrospinal fluid of patients with Alzheimer's disease, multi-infarct dementia and normal pressure hydrocephalus and compared with levels from a normal control group. All pathological groups showed a statistically significant decrease of somatostatin with respect to the control g...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00319684
更新日期:1991-06-01 00:00:00
abstract::The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050301
更新日期:1999-01-01 00:00:00
abstract::Four cases of mild botulinus type B intoxication are reported with the clinical neurophysiological studies. Electromyographically tetanic stimulation of the N. ulnaris initially led to tetanic potentiation of the muscle action potential. After an interval without any symptoms tetanic reduction became apparent between ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00312957
更新日期:1978-02-14 00:00:00
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journal_title:Journal of neurology
pub_type: 信件,评审
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更新日期:2009-11-01 00:00:00
abstract::Multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system (CNS), 2 results in damage to axons and their surrounding myelin sheath. The exact cause of inflammation remains unclear, but an autoimmune response directed against CNS antigens is suspected. MS can affect the brain, optic nerve an...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-004-1504-y
更新日期:2004-09-01 00:00:00
abstract:: ...
journal_title:Journal of neurology
pub_type: 信件
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313651
更新日期:1984-01-01 00:00:00
abstract::Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a common autoimmune encephalitis presenting with psychosis, dyskinesias, autonomic dysfunction and seizures. The underlying autoantibodies against the NR1 subunit are directly pathogenic by disrupting synaptic NMDAR currents. However, antibody titers correlate...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9042-1
更新日期:2018-11-01 00:00:00
abstract::The neutrotrophins stimulate survival and differentiation of a range of target neurons. A wealth of evidence suggests that central cholinergic neurons depend on nerve growth factor (NGF) for trophic support. Grafts of NGF-producing cells rescue axotomized basal forebrain cholinergic neurons and reduce cholinergic cell...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF00939231
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dysphagia is estimated to occur in up to 50% of the stroke neurorehabilitation population. Those patients with severe neurogenic oropharyngeal dysphagia (NOD) may receive feeding gastrostomy tubes (FGT) if noninvasive therapies prove ineffective in eliminating aspiration or sustaining adequate nu...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
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更新日期:2005-12-01 00:00:00
abstract::Acute mountain sickness (AMS) can occur during climbs to high altitudes and may seriously disturb the behavioral and intellectual capacities of susceptible subjects. During a Himalayan expedition 32 mountaineers were examined with electroencephalography (EEG) and transcranial doppler sonography (TCD) to assess relativ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0376-8
更新日期:2007-03-01 00:00:00