Abstract：
:Acute mountain sickness (AMS) can occur during climbs to high altitudes and may seriously disturb the behavioral and intellectual capacities of susceptible subjects. During a Himalayan expedition 32 mountaineers were examined with electroencephalography (EEG) and transcranial doppler sonography (TCD) to assess relative changes of middle cerebral artery velocity in relation to end-expiratory CO2 (EtCO2), peripheral saturation (SaO2), and symptoms of AMS. We tested the hypothesis that O2 desaturation and EtCO2 changes precede the development of AMS and result in brain dysfunction and compensatory mechanisms which can be measured by EEG and TCD, respectively. Contrary to our hypothesis, we found that subjects who later developed symptoms of AMS between 3,440 m and 5,050 m altitude exhibited an increase of slow cerebral activity in the right temporal region already at 3,440 m. Cerebral blood flow increased in these mountaineers in the right middle cerebral artery at 5,050 m. These findings indicate that regional brain dysfunction, which can be documented by EEG, heralds the appearance of clinical symptoms of AMS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Feddersen B,Ausserer H,Neupane P,Thanbichler F,Depaulis A,Waanders R,Noachtar Sdoi
10.1007/s00415-006-0376-8subject
Has Abstractpub_date
2007-03-01 00:00:00pages
359-63issue
3eissn
0340-5354issn
1432-1459journal_volume
254pub_type
杂志文章abstract：BACKGROUND:Stroke has a major impact on survivors. Our study was designed to describe the mental status and health-related quality of life (HRQoL) in long-term survivors of TIA or minor ischaemic stroke (MIS) and evaluate associations of mental and physical factors with HR-QoL. METHODS:A random sample of the 10-year s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0480-9
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Dysphagia is estimated to occur in up to 50% of the stroke neurorehabilitation population. Those patients with severe neurogenic oropharyngeal dysphagia (NOD) may receive feeding gastrostomy tubes (FGT) if noninvasive therapies prove ineffective in eliminating aspiration or sustaining adequate nu...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-005-0906-9
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The efficacy and safety of mechanical thrombectomy (MT) for M2 segment occlusion of middle cerebral artery in patients with acute ischemic stroke (AIS) was investigated. METHODS:We searched PubMed and EMBASE from inception to 16 April 2019 for relevant studies, calculated the pool relative risks...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-09710-w
更新日期：2020-01-22 00:00:00
abstract：:Unlike most neurodegenerative disorders, individuals at risk from Huntington's disease can be identified prior to the onset of clinical signs of the disease by virtue of it being an autosomal dominant condition. This provides the hypothetical opportunity to delay disease onset and/or slow down the progression of the d...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-015-7700-0
更新日期：2015-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-014-7303-1
更新日期：2014-05-01 00:00:00
abstract：:Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, se...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-0134-9
更新日期：2009-04-01 00:00:00
abstract：UNLABELLED:To systematically and comprehensively describe functioning and disability in Multiple sclerosis (MS), practical tools based on the International Classification of Functioning, Disability and Health (ICF), such as ICF Core Sets, are needed. OBJECTIVE:To report on the results of an evidence-based Internationa...
journal_title：Journal of neurology
pub_type： 共识发展会议,杂志文章
doi：10.1007/s00415-011-5963-7
更新日期：2011-08-01 00:00:00
abstract：:In this study of patients with spontaneous cervical artery dissections (sCAD) we searched for mutations in ABCC6, the candidate gene for Pseudoxanthoma elasticum (PXE). Genomic DNA samples from 12 sCAD patients with pronounced electron microscopic alterations in their dermal connective tissue and from 2 patients with ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-1139-4
更新日期：2003-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8114-3
更新日期：2016-06-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314720
更新日期：1978-04-14 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00878524
更新日期：1996-01-01 00:00:00
abstract：:Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literatu...
journal_title：Journal of neurology
pub_type： 指南,杂志文章,评审
doi：10.1007/s00415-016-8304-z
更新日期：2017-01-01 00:00:00
abstract：:Headache attributed to ingestion of a cold stimulus (ICHD-3 beta 4.5.1) is also known as ice cream headache (ICH). This cross-sectional epidemiological study included 283 students (10-14-year-olds) attending a grammar school in Germany, their parents (n = 401), and 41 teachers. A self-administered questionnaire was us...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8098-z
更新日期：2016-06-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal disease, leaving the patient in a partially or completely deafferented state. In an explorative study, we investigated responses to visual socio-emotional stimuli in ALS patients. Pictures from the International Affective Picture System (IAPS) were verbally judged by 12 m...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0907-8
更新日期：2005-12-01 00:00:00
abstract：:Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314359
更新日期：1988-03-01 00:00:00
abstract：:We examined 199 consecutive patients who underwent 220 liver transplantations, to define the type, frequency and aetiology of posttransplant neurological complications and their prognostic value. We found neurological complications in 63 patients (32%), mostly involving the central nervous system. The most frequent co...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444004
更新日期：1996-02-01 00:00:00
abstract：:Three families are described which include members with "typical" Friedreich's disease (FD) and others who are ataxic but do not satisfy all the diagnostic criteria for that disease. In family A two patients have an early-onset, rapidly progressive FD, while two others have a late-onset, more benign form. In families ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00319681
更新日期：1991-06-01 00:00:00
abstract：:Collective evidence supports the notion that multiple sclerosis is principally an autoimmune disease. Much of it stems from models of experimental autoimmune encephalomyelitis, generated by inoculation of animals with central nervous system antigens such as MBP, PLP, S100 and MOG or peptides thereof. Different ways of...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-005-5006-3
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the natu...
journal_title：Journal of neurology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0590-z
更新日期：2007-11-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6247-y
更新日期：2012-05-01 00:00:00
abstract：:Aquaporin-4 antibody (AQP4-Ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare but often severe autoimmune disease with median onset around 40 years of age. We report characteristics of three very-late-onset NMOSD (including complete NMO) patients >75 years of age, in whom this diagnosis initially se...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7766-8
更新日期：2015-05-01 00:00:00
abstract：:The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-017-8618-5
更新日期：2017-11-01 00:00:00
abstract：:A linkage and association of the CD45 (protein-tyrosine phosphatase, receptor-type C) C77G polymorphism and multiple sclerosis (MS) has been found in some studies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the transmission disequil...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0485-1
更新日期：2004-09-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0718-y
更新日期：2005-06-01 00:00:00
abstract：:Clinical and neuropathological data of a 50-year-old woman with an unusual multisystem degeneration are presented. Clinically the illness was characterized by progressive ataxia with ophthalmoplegia and multiple cranial nerve palsies. Neuropathological investigation showed a severe and selective degeneration of the de...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313709
更新日期：1985-01-01 00:00:00
abstract：:Premature atherosclerosis and cardiac complications have been reported among the systemic manifestations of cerebrotendinous xanthomatosis (CTX), a rare bile acid disorder with predominantly neurological features. In some cases, myocardial infarction has been the cause of sudden death. We examined nine CTX patients to...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050274
更新日期：1998-11-01 00:00:00
abstract：:This review summarizes the most relevant articles from the field of neuro-ophthalmology published in the Journal of Neurology from January 2012 to July 2013. With the advent of video-oculography, several articles describe new applications for eye movement recordings as a diagnostic tool for a wide range of disorders. ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-013-7105-x
更新日期：2014-07-01 00:00:00
abstract：:A 56-year-old woman with coeliac disease developed myoclonus of cortical origin and palatal myoclonus with lesions of subcortical white matter on magnetic resonance imaging. Myoclonus can thus be a prominent feature of coeliac disease encephalopathy. A slight vitamin E deficiency was found but does not satisfactorily ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314464
更新日期：1989-07-01 00:00:00
abstract：INTRODUCTION:Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy. METHODS:All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years. RESULTS:Five patients with intracrani...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0065-7
更新日期：2006-05-01 00:00:00
