Abstract:
:Mutations in the SPG3A gene cause a form of pure, early-onset autosomal dominant hereditary spastic paraplegia linked to chromosome 14q. The encoded protein, atlastin, is a putative member of the dynamin superfamily of large GTPases involved in cellular trafficking patterns. We report a new atlastin mutation causing spastic paraplegia in association with axonal neuropathy in an Italian family.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Scarano V,Mancini P,Criscuolo C,De Michele G,Rinaldi C,Tucci T,Tessa A,Santorelli FM,Perretti A,Santoro L,Filla Adoi
10.1007/s00415-005-0768-1keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
901-3issue
8eissn
0340-5354issn
1432-1459journal_volume
252pub_type
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