当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Dexamethasone for adult community-acquired bacterial meningitis: 20 years of experience in daily practice.

Dexamethasone for adult community-acquired bacterial meningitis: 20 years of experience in daily practice.

Abstract：

UNLABELLED:The aim of the study was to assess adjunctive intravenous dexamethasone in adult community-acquired bacterial meningitis (BM) in daily practice. Analysis of consecutive patients (1990-2009) with acute community-acquired bacterial meningitis in a single centre in Zagreb, Croatia, N = 304. Adjusted relative risks [RR, dexamethasone vs. no dexamethasone (control)] of Glasgow Outcome Scale (GOS) = 1 (death) and GOS = 5 (full recovery) at discharge/end of specific treatment were estimated considering demographics; co-morbidity; BM pathogenesis and on-admission characteristics, and cerebrospinal fluid (CSF) inflammation markers; causative agent and antibiotic use. Two hundred forty (79%) patients had proven BM (43.1% Streptococcus pneumoniae, any other agent ≤ 8.2%). No independent effects of dexamethasone on GOS = 1 or GOS = 5 were observed in the entire cohort (dexamethasone n = 119, control n = 185; RR = 1.06, 95% CI 0.77-1.45 and RR = 0.99, CI 0.83-1.20, respectively), microbiologically proven disease (dexamethasone n = 104, control n = 136; RR = 0.97, CI 0.69-1.38 and RR = 1.03, CI 0.82-1.28), pneumococcal disease (dexamethasone n = 71, control n = 60; RR = 0.95, CI 0.53-1.70 and RR = 0.82, CI 0.57-1.18), and also in other BM, subgroups based on consciousness disturbance, CSF markers, prior use of antibiotics and timing of appropriate antibiotic treatment. CSF markers did not predict the outcomes. CONCLUSIONS:Our experience does not substantiate the reported benefits of adjunctive dexamethasone in adult BM. Socio-economic and methodological factors do not seem to explain this discrepancy. Empirical use of dexamethasone in this setting appears controversial.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Peterković V,Trkulja V,Kutleša M,Krajinović V,Lepur D

doi

10.1007/s00415-011-6150-6

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

225-36

issue

2

eissn

0340-5354

issn

1432-1459

journal_volume

259

pub_type

杂志文章

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Utility of a next-generation sequencing-based gene panel investigation in German patients with genetically unclassified limb-girdle muscular dystrophy.

    abstract：:Limb-girdle muscular dystrophies (LGMDs) are genetically heterogeneous and the diagnostic work-up including conventional genetic testing using Sanger sequencing remains complex and often unsatisfactory. We performed targeted sequencing of 23 LGMD-related genes and 15 genes in which alterations result in a similar phen...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-016-8036-0

    authors： Kuhn M,Gläser D,Joshi PR,Zierz S,Wenninger S,Schoser B,Deschauer M

    更新日期：2016-04-01 00:00:00

  • Complex compulsive behaviour in the temporal variant of frontotemporal dementia.

    abstract：OBJECTIVE:As metabolic and structural changes in frontotemporal-subcortical pathways have been reported in patients with obsessive-compulsive disorders, we investigated the correlation between complex compulsive behaviour (CCB) and the distribution of atrophy in a group of 90 patients with frontotemporal dementia (FTD)...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s004150170049

    authors： Rosso SM,Roks G,Stevens M,de Koning I,Tanghe HLJ,Kamphorst W,Ravid R,Niermeijer MF,van Swieten JC

    更新日期：2001-11-01 00:00:00

  • Migraine prophylactic management in neurology and primary care (2006-2015).

    abstract：: ...

    journal_title：Journal of neurology

    pub_type： 信件

    doi：10.1007/s00415-018-9066-6

    authors： Jackson JL,Kay C,Scholcoff C,Nickoloff S,Fletcher K

    更新日期：2018-12-01 00:00:00

  • Intrathecal thyrotropin-releasing hormone therapy of amyotrophic lateral sclerosis.

    abstract：:Six patients with amyotrophic lateral sclerosis were given from 800 to 4000 micrograms of thyrotropin-releasing hormone (TRH) intrathecally for a period of 2-6 months. The progressive course of this disease, manifested by increasing atrophy, paralysis and disability score, was not altered. This supports the hypothesis...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314033

    authors： Stober T,Schimrigk K,Dietzsch S,Thielen T

    更新日期：1985-01-01 00:00:00

  • Short-term and long-term effects of immunoadsorption in refractory chronic inflammatory demyelinating polyneuropathy: a prospective study in 17 patients.

    abstract：OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, autoimmune-inflammatory disease of the peripheral nervous system. Recently, various immunoglobulin G4 (IgG4) type auto-antibodies have been described in patients with CIDP which can effectively be removed by immunoadsorption (IA). Therefore, ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-9082-6

    authors： Dorst J,Ludolph AC,Senel M,Tumani H

    更新日期：2018-12-01 00:00:00

  • Spinal epidural abscess complicating chronic epidural analgesia in 11 cancer patients: clinical findings and magnetic resonance imaging.

    abstract：:We reviewed the records of all patients who had received an epidural catheter for management of chronic cancer pain in a 3-year period (1993-1996). Patients with nervous system infections were identified, and pertinent clinical, radiological (magnetic resonance imaging), and bacteriological data were analyzed. We iden...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s004150050460

    authors： Sillevis Smitt P,Tsafka A,van den Bent M,de Bruin H,Hendriks W,Vecht C,Teng-van de Zande F

    更新日期：1999-09-01 00:00:00

  • When is there a full recovery for a myasthenia gravis patient?

    abstract：:A myasthenia gravis (MG) patient who seems to have recovered can later have recurrence of myasthenic signs. Clearly clinical remission does not always correspond to the normalization of all the factors involved in the pathogenesis of the disease. In ten patients who had apparently recovered from MG, electromyographic ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313771

    authors： Scoppetta C,Bartoccioni E,David P,Flamini G,Lo Monaco M,Scuderi F,Tonali P

    更新日期：1982-01-01 00:00:00

  • Richards-Rundle syndrome, cochleovestibular dysfunction and neurofibromatosis in a family.

    abstract：:The Richards-Rundle syndrome (RRS) is characterized by hearing loss, mental deterioration, ataxia, primary hypogonadism and autosomal recessive transmission. In a sibship of six members we found two sisters with RRS together with baldness, impaired GH and PRL secretion after stimulation and different degrees of impair...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313645

    authors： Franceschi M,Parmigiani F,Zamproni P,Cairoli G,Canal N

    更新日期：1984-01-01 00:00:00

  • Clinical experience with oral sumatriptan: a placebo-controlled, dose-ranging study. Oral Sumatriptan Dose-defining Study Group.

    abstract：:A double-blind, placebo-controlled multicentre study was carried out to evaluate the efficacy and tolerability of 100, 200 and 300 mg sumatriptan, a selective 5-hydroxytryptamine (5-HT)1-like receptor agonist, given in an oral dispersible form in the acute treatment of migraine attacks. A total of 1130 patients were r...

    journal_title：Journal of neurology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF01642909

    authors： Patten JP

    更新日期：1991-01-01 00:00:00

  • Clinical characteristics and outcomes between children and adults with anti-N-Methyl-D-Aspartate receptor encephalitis.

    abstract：:Anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis is an acute neurological disorder affecting children and adults. We aimed to compare the clinical characteristics, treatments, and outcomes between children and adults with anti-NMDAR encephalitis and to assess the probable risk factors. In this observational stu...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-016-8282-1

    authors： Huang Q,Wu Y,Qin R,Wei X,Ma M

    更新日期：2016-12-01 00:00:00

  • Dumb-bell sarcoma of the foramen jugulare with syringomyelia. A radio-induced tumour?

    abstract：:The clinicopathological findings of a 50-year-old man, who developed cervicothoracic syringomyelia at the age of 25 are presented. He was given radiation therapy at the age of 33. At the age of 57 he developed a foramen jugulare syndrome on the left, caused by a low grade leiomyosarcoma. Etiologically, the most attrac...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313150

    authors： Sieben G,Sieben-Praet M,De Reuck J,De Coster W,Remouchamps A,Roels H,vander Eecken H

    更新日期：1980-01-01 00:00:00

  • Clinical and biochemical evidence of skeletal muscle involvement in galactose-1-phosphate uridyl transferase deficiency.

    abstract：:An 8-year-old boy with galactose-1-phosphate uridyl transferase (GALT) deficiency presented with hypotonia, muscle hypotrophy, hepatomegaly, bilateral cataract and mild mental retardation. Two brothers showed a GALT activity consistent with a homozygotic condition and both parents were found to be heterozygotes for th...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00838160

    authors： Bresolin N,Comi GP,Fortunato F,Meola G,Gallanti A,Tajana A,Velicogna M,Gonano EF,Ninfali P,Pifferi S

    更新日期：1993-05-01 00:00:00

  • MR-imaging pattern is not a predictor of occult atrial fibrillation in patients with cryptogenic stroke.

    abstract：BACKGROUND:To date, insertable cardiac monitors (ICMs) are the most effective method for the detection of occult atrial fibrillation (AF) in cryptogenic stroke. The overall detection rate after 12 months, however, is low and ranges between 12.4 and 33.3%, even if clinical predictors are considered. Ischemic stroke pati...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09524-5

    authors： Vollmuth C,Stoesser S,Neugebauer H,Hansel A,Dreyhaupt J,Ludolph AC,Kassubek J,Althaus K

    更新日期：2019-12-01 00:00:00

  • A randomised controlled trial of treatment for idiopathic intracranial hypertension.

    abstract：:The cause of idiopathic intracranial hypertension (IIH) remains unknown, and no consensus exists on how patients should be monitored and treated. Acetazolamide is a common treatment but has never been examined in a randomised controlled trial. The objectives of this pilot trial are to prospectively evaluate the use of...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00415-010-5861-4

    authors： Ball AK,Howman A,Wheatley K,Burdon MA,Matthews T,Jacks AS,Lawden M,Sivaguru A,Furmston A,Howell S,Sharrack B,Davies MB,Sinclair AJ,Clarke CE

    更新日期：2011-05-01 00:00:00

  • Natural history of most common spinocerebellar ataxia: a systematic review and meta-analysis.

    abstract：BACKGROUND:Spinocerebellar ataxias (SCAs) are rare dominantly inherited neurodegenerative disorders that lead to severe disability and premature death. OBJECTIVE:To better characterize the natural history of the most common SCAs, SCA1, SCA2, SCA3 and SCA6, we performed a meta-analysis of literature to determine diseas...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-020-09815-2

    authors： Diallo A,Jacobi H,Tezenas du Montcel S,Klockgether T

    更新日期：2020-04-07 00:00:00

  • Cricopharyngeal bar on videofluoroscopy: high specificity for inclusion body myositis.

    abstract：OBJECTIVE:To determine the prevalence and characteristics of the cricopharyngeal bar (CPB), defined as marked protrusion with lacking relaxation and stricture of the upper esophageal sphincter on videofluoroscopy, in patients with inclusion body myositis (IBM). METHODS:We conducted a case-control study of comprehensiv...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10241-7

    authors： Taira K,Yamamoto T,Mori-Yoshimura M,Sajima K,Takizawa H,Shinmi J,Oya Y,Nishino I,Takahashi Y

    更新日期：2020-09-26 00:00:00

  • Sensory loss, pains, motor deficit and axonal regeneration in length-dependent diabetic polyneuropathy.

    abstract：:In order to learn more on the occurrence of pains and motor deficit in severe diabetic polyneuropathy we reviewed the data of a series of 30 diabetic patients with an uncommonly severe length-dependent diabetic polyneuropathy (LDDP). Extensive sensory loss predominated with pains and temperature sensations and affecte...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-008-0999-z

    authors： Said G,Baudoin D,Toyooka K

    更新日期：2008-11-01 00:00:00

  • Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population.

    abstract：:We examined the influence of alleles at the HLA loci, previously found to be associated with multiple sclerosis (MS) in Sardinia, on the clinical course of the disease in 835 relapsing (R) and 100 primary progressive (PP) patients. Multivariate analysis was carried out on predisposing 0301 or non-associated DPB1 allel...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0957-y

    authors： Marrosu MG,Cocco E,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Sardu C,Contu P

    更新日期：2006-02-01 00:00:00

  • Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.

    abstract：OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10004-4

    authors： Buchanan SM,Parker TD,Lane CA,Keshavan A,Keuss SE,Lu K,James SN,Murray-Smith H,Wong A,Nicholas J,Cash DM,Malone IB,Coath W,Thomas DL,Sudre C,Fox NC,Richards M,Schott JM

    更新日期：2020-11-01 00:00:00

  • Prognostic value of decreased tongue strength on survival time in patients with amyotrophic lateral sclerosis.

    abstract：:Decreased tongue strength (TS) might herald bulbar involvement in patients with amyotrophic lateral sclerosis (ALS) well before dysarthria or dysphagia occur, and as such might be prognostic of short survival. The purpose of this study was to investigate the prognostic value of a decreased TS, in addition to other pro...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-012-6503-9

    authors： Weikamp JG,Schelhaas HJ,Hendriks JC,de Swart BJ,Geurts AC

    更新日期：2012-11-01 00:00:00

  • Congenital isolated hemifacial hyperplasia.

    abstract：:We report on a 14-year-old boy with congenital isolated hemifacial hyperplasia. Hemifacial hypertrophy most likely represents a minor form of congenital hemihypertrophy. MRI of the soft tissue is particularly suitable to support the diagnosis and reveal associated bony asymmetries. ...

    journal_title：Journal of neurology

    pub_type： 信件

    doi：10.1007/s00415-009-5148-9

    authors： Urban PP,Bruening R

    更新日期：2009-09-01 00:00:00

  • Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

    abstract：OBJECTIVE:Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lo...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-09824-1

    authors： Murley AG,Jones PS,Coyle Gilchrist I,Bowns L,Wiggins J,Tsvetanov KA,Rowe JB

    更新日期：2020-08-01 00:00:00

  • Rapid-eye-movement sleep behavior disorder secondary to acute aseptic limbic encephalitis.

    abstract：:Rapid-eye-movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by complex motor activity associated with dreaming during REM sleep. RBD may be idiopathic or associated with various neurological diseases involving the brainstem. The association of RBD and limbic system impairment was unclear. We r...

    journal_title：Journal of neurology

    pub_type： 信件

    doi：10.1007/s00415-009-5067-9

    authors： Lin FC,Liu CK,Hsu CY

    更新日期：2009-07-01 00:00:00

  • Cytotoxic anti-lymphocyte antibody in schizophrenics.

    abstract：:An IgM antibody cytotoxic to normal human lymphocytes was found in 46.2% (male: 61.5%; female: 30.8%) of sera from chronic schizophrenics by means of a complement-dependent cytotoxicity test. The relationship between this antibody and the immunological manifestations of schizophrenia is discussed. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314296

    authors： Kagami M,Koike T,Maruyama N,Takabayashi K,Tomioka H,Yoshida S,Kon Y

    更新日期：1987-06-01 00:00:00

  • Low prevalence of ataxic polyneuropathy in a community with high exposure to cyanide from cassava foods.

    abstract：INTRODUCTION:Ataxic polyneuropathy, which occurs in endemic form in an area in southwest Nigeria, is attributed to exposure to cyanide from cassava foods. Exposure to cyanide from cassava is, however, not exclusive to this endemic area. In this study, the occurrence of ataxic polyneuropathy was compared in two communit...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-002-0779-0

    authors： Oluwole OS,Onabolu AO,Cotgreave IA,Rosling H,Persson A,Link H

    更新日期：2002-08-01 00:00:00

  • The course of multiple sclerosis rewritten: a Norwegian population-based study on disease demographics and progression.

    abstract：OBJECTIVES:Over the past few decades, there has been an improvement in the rate of disability progression in multiple sclerosis (MS) patients, and most studies relate this evolvement to the introduction of disease-modifying therapies. However, several other factors have changed over this period, including access to MRI...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10279-7

    authors： Simonsen CS,Flemmen HØ,Broch L,Brunborg C,Berg-Hansen P,Moen SM,Celius EG

    更新日期：2020-10-22 00:00:00

  • Acetylcholine-receptor-like protein from human thymoma associated with myasthenia gravis.

    abstract：:Cobrotoxin-binding protein was isolated by affinity chromatography from human thymoma which had been surgically removed from patients with myasthenia gravis. The protein was composed of polypeptides with a molecular mass of 40, 51, 65, and 74 kilodaltons as determined by polyacrylamide gel electrophoresis in the prese...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00618251

    authors： Kawanami S,Kamei H,Oita J,Kurokawa M,Uchida Y,Hayashi K

    更新日期：1987-05-01 00:00:00

  • Cerebral disseminated coagulation. An encephalitis-like syndrome in a boy with dissecting aortic aneurysm.

    abstract：:A boy was suspected of having meningoencephalitis probably of viral origin, although all microbiological, including virological, tests were negative. Postmortem examination revealed a dissecting aortic aneurysm and disseminated intravascular coagulation involving the central nervous system exclusively. The clinical ev...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313465

    authors： Hens L,Dom R,Goddeeris P,van den Bergh R

    更新日期：1981-01-01 00:00:00

  • Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.

    abstract：:To further evaluate (1) transcranial sonography (TCS) for (pre)clinical diagnosis of Parkinson's disease (PD) and (2) to examine asymptomatic carriers of Parkin mutations we investigated substantia nigra (SN) hyperechogenicity in PD patients and unaffected subjects with and without Parkin mutations. The area (aSN) of ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-007-0567-y

    authors： Hagenah JM,König IR,Becker B,Hilker R,Kasten M,Hedrich K,Pramstaller PP,Klein C,Seidel G

    更新日期：2007-10-01 00:00:00

  • Effects of IVIg treatment on autoantibody testing in neurological patients: marked reduction in sensitivity but reliable specificity.

    abstract：BACKGROUND:Therapy of autoimmune diseases of the central and peripheral nervous system with intravenous IgG immunoglobulin (IVIg) is well established. Since IVIg is produced from pooled human plasma, autoantibodies can be found in IVIg products and, accordingly, in patient sera after transfusion. The de novo evidence o...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09614-4

    authors： Grüter T,Ott A,Meyer W,Jarius S,Kinner M,Motte J,Pitarokoili K,Gold R,Komorowski L,Ayzenberg I

    更新日期：2020-03-01 00:00:00