Abstract:
:Limb-girdle muscular dystrophies (LGMDs) are genetically heterogeneous and the diagnostic work-up including conventional genetic testing using Sanger sequencing remains complex and often unsatisfactory. We performed targeted sequencing of 23 LGMD-related genes and 15 genes in which alterations result in a similar phenotype in 58 patients with genetically unclassified LGMDs. A genetic diagnosis was possible in 19 of 58 patients (33 %). LGMD2A was the most common form, followed by LGMD2L and LGMD2I. In two patients, pathogenic mutations were identified in genes that are not classified as LGMD genes (glycogen branching enzyme and valosin-containing protein). Thus, a focused next-generation sequencing-based gene panel is a rather satisfactory tool for the diagnosis in unclassified LGMDs.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Kuhn M,Gläser D,Joshi PR,Zierz S,Wenninger S,Schoser B,Deschauer Mdoi
10.1007/s00415-016-8036-0subject
Has Abstractpub_date
2016-04-01 00:00:00pages
743-50issue
4eissn
0340-5354issn
1432-1459pii
10.1007/s00415-016-8036-0journal_volume
263pub_type
杂志文章abstract::Frailty is known to predict dementia. However, its link with neurodegenerative alterations of the central nervous system (CNS) is not well understood at present. We investigated the association between the biomechanical response of the CNS and frailty in older adults suspected of normal pressure hydrocephalus (NPH) pr...
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更新日期:2021-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2001-08-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314606
更新日期:1975-06-09 00:00:00
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更新日期:2019-12-01 00:00:00
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更新日期:1983-01-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 信件
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