The impact of the initial severity on later outcome: retrospective analysis of a large cohort of botulinum toxin naïve patients with idiopathic cervical dystonia.

abstract：BACKGROUND AND AIMS:Most patients with multiple sclerosis presenting with a relapsing-remitting disease course at diagnosis transition to secondary progressive multiple sclerosis (SPMS) 1-2 decades after onset. SPMS is characterized by predominant neurodegeneration and atrophy. These pathogenic hallmarks result in unsa...

journal_title：Journal of neurology

authors： Ferrazzano G,Crisafulli SG,Baione V,Tartaglia M,Cortese A,Frontoni M,Altieri M,Pauri F,Millefiorini E,Conte A

更新日期：2020-06-05 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare late onset neurodegenerative disorder which presents with autonomic failure and a complicated motor syndrome including atypical parkinsonism, ataxia and pyramidal signs. MSA is a glial alpha-synucleinopathy with rapid progression and currently poor therapeutic management. This p...

journal_title：Journal of neurology

authors： Wenning GK,Stefanova N

更新日期：2009-11-01 00:00:00

abstract：:Even though trigeminovestibular connections are well established in animals, mastication-induced dizziness has been described only as a vascular steal phenomenon in humans. We determined induction or modulation of nystagmus in two index patients with mastication-induced vertigo, 12 normal controls, and 52 additional p...

journal_title：Journal of neurology

authors： Park SH,Kim HJ,Kim JS,Koo JW,Oh SW,Kim DU,Kim JT,Welgampola M,Deriu F

更新日期：2014-03-01 00:00:00

abstract：:Most inflammatory neuropathies, both acute and chronic, probably result from an immune attack against antigens of the peripheral nervous system. Specific antibodies in serum that react with the peripheral nervous system have been described in a number of inflammatory neuropathies. We review the pathophysiological sign...

journal_title：Journal of neurology

authors： Steck AJ

更新日期：2000-06-01 00:00:00

abstract：:Peripheral neuropathies have various causes, both infectious and non-infectious. When we think of "epidemics", we often refer to an infectious or even post-infectious origin. Nevertheless, the history of mankind is marked by episodes of epidemics of peripheral neuropathies of non-infectious nature, either of nutrition...

journal_title：Journal of neurology

authors： Mathis S,Soulages A,Vallat JM,Le Masson G

更新日期：2020-09-11 00:00:00

abstract：:Thinning of the retinal nerve fiber layer (RNFL) of clinically unaffected eyes is seen in patients with multiple sclerosis (MS). It is uncertain when this thinning occurs, and whether ongoing RNFL loss can be measured over time with optical coherence tomography (OCT). Using time-domain OCT, we studied 34 patients with...

journal_title：Journal of neurology

authors： Henderson AP,Trip SA,Schlottmann PG,Altmann DR,Garway-Heath DF,Plant GT,Miller DH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The treatment of MS has always been a focus of neurological research. To date, the US Food and Drug Administration has approved 15 medications for modifying the course of multiple sclerosis. In this study, we exami...

journal_title：Journal of neurology

authors： Li H,Hu F,Zhang Y,Li K

更新日期：2020-12-01 00:00:00

abstract：:Posterior leukoencephalopathy typically denotes neurotoxicity from immunosuppressive agents, malignant hypertension or eclampsia. It has not been documented in central nervous system angiitis. We present three cases associated with isolated cerebral angiitis after review of all cases of isolated CNS angiitis from 1998...

journal_title：Journal of neurology

authors： Wijdicks EF,Manno EM,Fulgham JR,Giannini C

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:The variability of the severity and regional distribution of pathological process in basal ganglia (BG) and brainstem-cerebellar systems results in clinical heterogeneity and represents the motor subtype of multiple system atrophy (MSA). This study aimed to quantify spatial patterns of multimodal MRI abnormal...

journal_title：Journal of neurology

authors： Lee MJ,Kim TH,Mun CW,Shin HK,Son J,Lee JH

更新日期：2018-07-01 00:00:00

abstract：:The influence of portal-systemic shunting on maximal motor nerve conduction velocity (MCV) was analyzed in rats with portacaval shunts. At 3 and 8 weeks after the shunting there was a marked but transient fall in MCV. This was not prevented by colectomy. At 16 weeks the MCV had almost normalized, despite sustained por...

journal_title：Journal of neurology

authors： Hindfelt B,Holmin T

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To characterize the progression of the cognitive involvement in patients affected by myotonic dystrophy type 1 (DM1) by a longitudinal neuropsychological follow-up study. METHODS:In a previous study we documented an ageing-related decline of frontal and temporal cognitive functions in juvenile/adult forms of...

journal_title：Journal of neurology

authors： Modoni A,Silvestri G,Vita MG,Quaranta D,Tonali PA,Marra C

更新日期：2008-11-01 00:00:00

abstract：:Little is known about the relationship between cognitive dysfunctions and the non-motor complex in subjects with newly diagnosed untreated Parkinson's disease (PD). The aim of this study was to explore the association between non-motor symptoms (NMS) and cognitive dysfunctions in an incident cohort of de novo, drug-na...

journal_title：Journal of neurology

authors： Erro R,Santangelo G,Picillo M,Vitale C,Amboni M,Longo K,Costagliola A,Pellecchia MT,Allocca R,De Rosa A,De Michele G,Santoro L,Barone P

更新日期：2012-09-01 00:00:00

abstract：:Activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) represent a powerful tool to study the functional anatomy of Parkinson's disease (PD). Activation studies offer the opportunity to study regional cerebral function in man in vivo under different conditions with ...

journal_title：Journal of neurology

authors： Ceballos-Baumann AO

更新日期：2003-02-01 00:00:00

abstract：:The management of high-grade glioma (HGG) has evolved significantly over the last decade. Patients are managed in a multidisciplinary team setting in order to ensure their care is guided by the most current evidenced based treatments. The outcome in patients with HGG, while still poor, has improved in terms of both su...

journal_title：Journal of neurology

authors： Bradley D,Rees J

更新日期：2014-04-01 00:00:00

abstract：:The etiology of spontaneous cervical artery dissection (sCAD) is unknown. An underlying connective tissue disorder has been suggested. As a collagen disease is conceivable several genes encoding fibrillar collagens have been condsidered as candidate genes for sCAD. We analysed the COL3A1 gene in patients with spontane...

journal_title：Journal of neurology

authors： von Pein F,Välkkilä M,Schwarz R,Morcher M,Klima B,Grau A,Ala-Kokko L,Hausser I,Brandt T,Grond-Ginsbach C

更新日期：2002-07-01 00:00:00

abstract：:We report two cases of unilateral spatial neglect associated with an isolated right frontal lobe lesion. Case 1 was a 59-year-old, right-handed man, who developed a left hemiplegia, disorientation, and frontal lobe neglect associated with a haemorrhagic contusion following a head injury. Case 2 was a 55-year-old, righ...

journal_title：Journal of neurology

authors： Maeshima S,Terada T,Nakai K,Nishibayashi H,Ozaki F,Itakura T,Komai N

更新日期：1995-10-01 00:00:00

abstract：:Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units...

journal_title：Journal of neurology

authors： Müller F,Moskophidis M,Schmitz H

更新日期：1988-03-01 00:00:00

abstract：:The occurrence of spontaneous internal carotid or vertebral artery dissection after childbirth remains rare. To our knowledge, seven cases of arterial dissection in the postpartum period have been described in the literature as single case reports. We report four additional cases of internal carotid and vertebral arte...

journal_title：Journal of neurology

authors： Gasecki AP,Kwiecinski H,Lyrer PA,Lynch TG,Baxter T

更新日期：1999-08-01 00:00:00

abstract：:Autoradiographic investigations with 3H-thymidine were performed on cerebrospinal fluid (CSF) cells from a case of meningeal carcinomatosis following carcinoma of the breast. The cells were found to be anaplastic histologically. Within a period of 12 days 3 X 25 mg methotrexate were injected into the subarachnoid spac...

journal_title：Journal of neurology

authors： Engelhardt P

更新日期：1976-10-04 00:00:00

abstract：:Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA. During the 5-year observation period, 10 of 45 patients with probable MSA died. The ...

journal_title：Journal of neurology

authors： Shimohata T,Ozawa T,Nakayama H,Tomita M,Shinoda H,Nishizawa M

更新日期：2008-10-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is an uncommon, demyelinating disease that causes long-term disability in adults. Though much has recently been learned about its pathogenesis, there are still only a few studies regarding the epidemiology of NMO. The aim of the study was to describe the epidemiology of NMO among adults in t...

journal_title：Journal of neurology

authors： Jacob A,Panicker J,Lythgoe D,Elsone L,Mutch K,Wilson M,Das K,Boggild M

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Epilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whethe...

journal_title：Journal of neurology

authors： Jain P,Subendran J,Smith ML,Widjaja E,PEPSQOL Study Team.

更新日期：2018-10-01 00:00:00

abstract：:Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal con...

journal_title：Journal of neurology

authors： Ljubisavljevic S,Zidverc Trajkovic J

更新日期：2019-05-01 00:00:00

abstract：:Mitochondrial diseases are due to impairment of the mitochondrial respiratory chain. A plausible pathogenic mechanism leading to cellular dysfunction and phenotypic expression is oxidative stress, but there are surprisingly few clinical studies on this subject. Glutathione (GSH) deficiency has been reported in mitocho...

journal_title：Journal of neurology

authors： Mancuso M,Orsucci D,Logerfo A,Rocchi A,Petrozzi L,Nesti C,Galetta F,Santoro G,Murri L,Siciliano G

更新日期：2010-05-01 00:00:00

abstract：INTRODUCTION:Ataxic polyneuropathy, which occurs in endemic form in an area in southwest Nigeria, is attributed to exposure to cyanide from cassava foods. Exposure to cyanide from cassava is, however, not exclusive to this endemic area. In this study, the occurrence of ataxic polyneuropathy was compared in two communit...

journal_title：Journal of neurology

authors： Oluwole OS,Onabolu AO,Cotgreave IA,Rosling H,Persson A,Link H

更新日期：2002-08-01 00:00:00

abstract：:A boy was suspected of having meningoencephalitis probably of viral origin, although all microbiological, including virological, tests were negative. Postmortem examination revealed a dissecting aortic aneurysm and disseminated intravascular coagulation involving the central nervous system exclusively. The clinical ev...

journal_title：Journal of neurology

authors： Hens L,Dom R,Goddeeris P,van den Bergh R

更新日期：1981-01-01 00:00:00

abstract：:To evaluate the clinical and electrophysiological similarities and differences between two large groups of patients with Charcot-Marie-Tooth disease, i.e. CMT1A and CMT2, we performed a post hoc comparison of clinical and electrophysiological data. Most CMT1A and CMT2 patients had the classical CMT phenotype. Age of o...

journal_title：Journal of neurology

authors： Bienfait HM,Verhamme C,van Schaik IN,Koelman JH,de Visser BW,de Haan RJ,Baas F,van Engelen BG,de Visser M

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms. METHODS:Hundred-and-nineteen pat...

journal_title：Journal of neurology

authors： Tommasin S,De Giglio L,Ruggieri S,Petsas N,Giannì C,Pozzilli C,Pantano P

更新日期：2018-12-01 00:00:00

abstract：:Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified c...

journal_title：Journal of neurology

authors： Hiltunen S,Putaala J,Haapaniemi E,Tatlisumak T

更新日期：2016-03-01 00:00:00

abstract：:In Huntington's disease (HD) atrophy of the caudate nucleus and putamen has been described many years before clinical manifestation. Volume changes of the pallidum, thalamus, brainstem, accumbens nucleus, hippocampus, and amygdala are less well investigated, or reported with contradicting results. The aim of our study...

journal_title：Journal of neurology

authors： van den Bogaard SJ,Dumas EM,Acharya TP,Johnson H,Langbehn DR,Scahill RI,Tabrizi SJ,van Buchem MA,van der Grond J,Roos RA,TRACK-HD Investigator Group.

更新日期：2011-03-01 00:00:00