Abstract:
:Cobrotoxin-binding protein was isolated by affinity chromatography from human thymoma which had been surgically removed from patients with myasthenia gravis. The protein was composed of polypeptides with a molecular mass of 40, 51, 65, and 74 kilodaltons as determined by polyacrylamide gel electrophoresis in the presence of sodium dodecylsulphate. Isoelectric focusing of the protein gave pI values of 5.2-5.6 and 11. This is the first report of the isolation of the protein from human thymoma. These findings suggest that the cobrotoxin-binding protein from human thymoma patients with myasthenia gravis has subunits similar to those of fish electric organs or mammalian muscles.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Kawanami S,Kamei H,Oita J,Kurokawa M,Uchida Y,Hayashi Kdoi
10.1007/BF00618251subject
Has Abstractpub_date
1987-05-01 00:00:00pages
207-10issue
4eissn
0340-5354issn
1432-1459journal_volume
234pub_type
杂志文章abstract::We report the familial occurrence and apparent autosomal dominant inheritance of Sneddon's syndrome with variable clinical expression. The proband, a 40-year-old woman, presented with livedo reticularis and progressive neurological deterioration following a stroke. The diagnosis was confirmed by cerebral angiogram and...
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更新日期:2016-07-01 00:00:00
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abstract::The diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy (PML) in multiple sclerosis patients in an asymptomatic stage is crucial since it is associated with better clinical outcome measures. Current diagnostic criteria on PML diagnosis in asymptomatic patients require the detection of JC vir...
journal_title:Journal of neurology
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更新日期:2014-06-01 00:00:00
abstract::To clarify the changes of cervical (cVEMP) and ocular (oVEMP) vestibular evoked myogenic potentials induced by air-conducted sound (ACS) and bone-conducted vibration (BCV) in patients with vestibular neuritis (VN), patients with VN (n = 30) and normal controls (n = 45) underwent recording of cVEMP and oVEMP in respons...
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abstract::Temporal lobe epilepsy has been usually associated with progressive brain atrophy due to neuronal cell loss. However, recent animal models demonstrated a dual effect of epileptic seizures with initial enhancement of hippocampal neurogenesis followed by abnormal astrocyte proliferation and neurogenesis depletion in the...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09546-z
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Ataxic polyneuropathy, which occurs in endemic form in an area in southwest Nigeria, is attributed to exposure to cyanide from cassava foods. Exposure to cyanide from cassava is, however, not exclusive to this endemic area. In this study, the occurrence of ataxic polyneuropathy was compared in two communit...
journal_title:Journal of neurology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7006-z
更新日期:2013-10-01 00:00:00
abstract::Sensory trick may relieve dystonic symptoms in patients with idiopathic cervical dystonia (CD). We investigated the patterns of brain functional MRI (fMRI) during resting state, sensory trick simulation and sensory trick imagination in CD patients both with and without an effective sensory trick. We recruited 17 CD pa...
journal_title:Journal of neurology
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更新日期:2020-04-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6407-0
更新日期:2012-09-01 00:00:00
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journal_title:Journal of neurology
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doi:10.1007/s00415-008-0779-9
更新日期:2008-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00919713
更新日期:1994-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313543
更新日期:1982-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10223-9
更新日期:2020-09-15 00:00:00
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pub_type: 信件
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更新日期:2009-07-01 00:00:00
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更新日期:1987-06-01 00:00:00
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journal_title:Journal of neurology
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更新日期:1982-01-01 00:00:00
abstract::Atrial fibrillation (AF) is a strong risk factor for first-ever stroke and stroke recurrence. The detection rate is low and detection is often costly and time-consuming. We evaluated the diagnostic yield of an external loop recorder (ELR) in patients with acute ischemic stroke or TIA, and assessed factors that are ass...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-014-7621-3
更新日期:2015-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-010-5768-0
更新日期:2011-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00