Prognostic criteria in an epidemiological group of patients with multiple sclerosis: an exploratory study.

abstract：:An IgM antibody cytotoxic to normal human lymphocytes was found in 46.2% (male: 61.5%; female: 30.8%) of sera from chronic schizophrenics by means of a complement-dependent cytotoxicity test. The relationship between this antibody and the immunological manifestations of schizophrenia is discussed. ...

journal_title：Journal of neurology

authors： Kagami M,Koike T,Maruyama N,Takabayashi K,Tomioka H,Yoshida S,Kon Y

更新日期：1987-06-01 00:00:00

abstract：:The computed tomography, magnetic resonance imaging and angiographic findings are described in a patient with Klippel-Trenaunay syndrome, who also had a cerebral haemorrhage from an arteriovenous malformation. The resulting aphasia disappeared completely after resorption of the haemorrhage. In this syndrome, the occur...

journal_title：Journal of neurology

authors： Jaksch H,Bewermeyer H,Dreesbach HA,Heiss WD

更新日期：1986-02-01 00:00:00

abstract：:Parvalbumin (a calcium-binding protein)-immunoreactive (PV-Ir) neurons in the cerebral cortex were examined in 20 postmortem brains obtained from elderly controls and patients with Pick's disease (PD). The type of PV-Ir neurons and their distribution in control and PD brains were similar. The number of PV-Ir neurons i...

journal_title：Journal of neurology

authors： Arai H,Noguchi I,Makino Y,Kosaka K,Heizmann CW,Iizuka R

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Contactin-associated protein-like 2 (CASPR2) autoantibody disease has a variable clinical phenotype. We present a case report and performed a systematic review of the literature to summarize: (1) the clinical phenotype of patients with CASPR2 antibodies, (2) the findings in neurological investigations, and (...

journal_title：Journal of neurology

authors： Boyko M,Au KLK,Casault C,de Robles P,Pfeffer G

更新日期：2020-04-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which was thought to be untreatable. However, recent evidence in both experimental animals and men indicates that antiglutamatergic strategies are the first to have an influence on its pathogenesis and slow down the disease process. Since the eff...

journal_title：Journal of neurology

authors： Ludolph AC

更新日期：2000-12-01 00:00:00

abstract：:The cases of identical twins with ataxia telangiectasia, early intellectual impairment and progressive spasticity are reported. Immunological tests revealed reduced levels of serum and salivary IgA, increased B cells, reduced T cells and raised alpha-fetoprotein. CT scan performed in one of the twins was normal. The p...

journal_title：Journal of neurology

authors： Meshram CM,Sawhney IM,Prabhakar S,Chopra JS

更新日期：1986-10-01 00:00:00

abstract：:The transcranial activation and the conduction properties of corticospinal and callosal neurons were investigated in 12 early-treated adolescents (aged 17.3, SD 3.5 years; range 14-27 years) with phenylketonuria (PKU) by focal transcranial magnetic stimulation (fTMS) of the motor cortex. The patients had no functional...

journal_title：Journal of neurology

authors： Röricht S,Meyer BU,Irlbacher K,Ludolph AC

更新日期：1999-01-01 00:00:00

abstract：:The experience of music is difficult to study objectively. Here we describe a detailed analysis of musical hallucinations developing after a probable brainstem stroke in an 83 year old musician who was able to describe and notate the hallucinations. The hallucinations comprised simple, repetitive melodic and rhythmic ...

journal_title：Journal of neurology

authors： Warren JD,Schott GD

更新日期：2006-08-01 00:00:00

abstract：:It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that ...

journal_title：Journal of neurology

authors： Josephs KA

更新日期：2015-03-01 00:00:00

abstract：:The greatest unmet need in multiple sclerosis (MS) are treatments that delay, prevent or reverse progression. One of the most tractable strategies to achieve this is to therapeutically enhance endogenous remyelination; doing so restores nerve conduction and prevents neurodegeneration. The biology of remyelination-cent...

journal_title：Journal of neurology

authors： Cunniffe N,Coles A

更新日期：2021-01-01 00:00:00

abstract：:Three families are described which include members with "typical" Friedreich's disease (FD) and others who are ataxic but do not satisfy all the diagnostic criteria for that disease. In family A two patients have an early-onset, rapidly progressive FD, while two others have a late-onset, more benign form. In families ...

journal_title：Journal of neurology

authors： Filla A,De Michele G,Cavalcanti F,Santorelli F,Santoro L,Campanella G

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Diagnostic delay of hereditary transthyretin amyloidosis (ATTRv, v for variant) prevents timely treatment and, therefore, concurs to the mortality of the disease. The aim of the present study was to explore with nerve ultrasound (US) possible red flags for early diagnosis in ATTRv patients with carpal tunnel...

journal_title：Journal of neurology

authors： Salvalaggio A,Coraci D,Cacciavillani M,Obici L,Mazzeo A,Luigetti M,Pastorelli F,Grandis M,Cavallaro T,Bisogni G,Lozza A,Gemelli C,Gentile L,Ermani M,Fabrizi GM,Plasmati R,Campagnolo M,Castellani F,Gasparotti R,Marti

更新日期：2021-01-01 00:00:00

abstract：:Dopamine agonists have been proved safe and effective as initial therapy in early stages of Parkinson's disease. Prospective long-term clinical trials demonstrated that initial symptomatic treatment with a dopamine agonist is associated with a significantly reduced risk for motor complications in comparison with levod...

journal_title：Journal of neurology

authors： Junghanns S,Glöckler T,Reichmann H

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Dysarthria may be classified as flaccid, spastic, ataxic, hypokinetic, choreatic, dystonic, or mixed. We hypothesized that in routine neurological practice the reliability and accuracy of perceptual analysis alone in the classification of dysarthria is low and that this classification is mainly based on the ...

journal_title：Journal of neurology

authors： Fonville S,van der Worp HB,Maat P,Aldenhoven M,Algra A,van Gijn J

更新日期：2008-10-01 00:00:00

abstract：:Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) are the major immune neuropathies. Although a detailed understanding of the pathogenesis of these conditions is not yet available, the multiple effects of IVIg on the immune and inflamm...

journal_title：Journal of neurology

authors： Hughes R

更新日期：2008-07-01 00:00:00

abstract：:Biomarkers beyond clinical assessment are needed in patients who suffer from amyotrophic lateral sclerosis (ALS). Here, single-voxel proton magnetic resonance spectroscopy ((1)H MRS) of the gray matter of the motor cortex and the white matter including the pyramidal tracts was used to investigate concentrations of N-a...

journal_title：Journal of neurology

authors： Unrath A,Ludolph AC,Kassubek J

更新日期：2007-08-01 00:00:00

abstract：:The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...

journal_title：Journal of neurology

authors： Denis HL,Lamontagne-Proulx J,St-Amour I,Mason SL,Weiss A,Chouinard S,Barker RA,Boilard E,Cicchetti F

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Ultrafast brain MRI is required for uncooperative patients and time-critical diseases such as stroke because it reduces scan times and motion artifacts. This study investigated the clinical feasibility of a 1-min ultrafast brain MRI protocol for detecting intracranial abnormalities in restless and uncooperat...

journal_title：Journal of neurology

authors： Ryu KH,Choi DS,Baek HJ,Cho SB,Ha JY,Kim TB,Hwang MJ

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To report the clinical features and long-term outcome of 22 newly diagnosed paraneoplastic patients with GABAB receptor antibodies (GABABR-Abs). METHODS:Retrospective clinical study of CSF-confirmed cases of GABABR-Abs encephalitis. RESULTS:We identified 22 patients (4 female) with GABABR-Abs, with a median...

journal_title：Journal of neurology

authors： Maureille A,Fenouil T,Joubert B,Picard G,Rogemond V,Pinto AL,Thomas L,Ducray F,Quadrio I,Psimaras D,Berzero G,Antoine JC,Desestret V,Honnorat J

更新日期：2019-01-01 00:00:00

abstract：:Fatigue is a common and frequently disabling symptom of multiple sclerosis (MS). The aim of this study was to develop the Fatigue index Kliniken Schmieder (FKS) for detecting motor fatigue in patients with MS using kinematic gait analysis. The FKS relies on the chaos theoretical term "attractor", which, if unchanged, ...

journal_title：Journal of neurology

authors： Sehle A,Vieten M,Sailer S,Mündermann A,Dettmers C

更新日期：2014-09-01 00:00:00

abstract：:The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phos...

journal_title：Journal of neurology

authors： Morgott UJ,Woelk H

更新日期：1975-01-01 00:00:00

abstract：:Cerebellar ataxia can have many genetic causes among which are the congenital disorders of glycosylation type I (CDG-I). In this group of disorders, a multisystem phenotype is generally observed including the involvement of many organs, the endocrine, hematologic and central nervous systems. A few cases of CDG-Ia have...

journal_title：Journal of neurology

authors： Vermeer S,Kremer HP,Leijten QH,Scheffer H,Matthijs G,Wevers RA,Knoers NA,Morava E,Lefeber DJ

更新日期：2007-10-01 00:00:00

abstract：:Few regional and seasonal Guillain-Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj)...

journal_title：Journal of neurology

authors： Schirmer L,Worthington V,Solloch U,Loleit V,Grummel V,Lakdawala N,Grant D,Wassmuth R,Schmidt AH,Gebhardt F,Andlauer TF,Sauter J,Berthele A,Lunn MP,Hemmer B

更新日期：2016-10-01 00:00:00

abstract：:We report the familial occurrence and apparent autosomal dominant inheritance of Sneddon's syndrome with variable clinical expression. The proband, a 40-year-old woman, presented with livedo reticularis and progressive neurological deterioration following a stroke. The diagnosis was confirmed by cerebral angiogram and...

journal_title：Journal of neurology

authors： Lossos A,Ben-Hur T,Ben-Nariah Z,Enk C,Gomori M,Soffer D

更新日期：1995-02-01 00:00:00

abstract：:Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...

journal_title：Journal of neurology

authors： Roddy J,Clark I,Hazleman BL,Compston DA,Scolding NJ

更新日期：1994-08-01 00:00:00

abstract：:The use of a dopamine agonist with a long duration of action has theoretical advantages in attempting to reduce the motor fluctuations in Parkinson's disease. We report the results of a double-blind controlled study of adding cabergoline, an ergot derivative with potent long-lasting high affinity for the D2 receptor, ...

journal_title：Journal of neurology

authors： Steiger MJ,El-Debas T,Anderson T,Findley LJ,Marsden CD

更新日期：1996-01-01 00:00:00

abstract：:The emotional and relationship problems associated with MS have not always been fully appreciated by the medical profession, which has tended to concentrate on the physical aspects of this disease. Yet the psychological problems of MS often cause more suffering than physical effects. ...

journal_title：Journal of neurology

authors： Kesselring J,Klement U

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To identify factors that impact on the ability of patients with multiple sclerosis (MS) to remain in work in order to make recommendations for future clinical management. METHODS:Cross-sectional studies using qualitative (phase one) and quantitative (phase two) methods. In phase one, 62 patients were intervi...

journal_title：Journal of neurology

authors： O'Connor RJ,Cano SJ,Ramió i Torrentà L,Thompson AJ,Playford ED

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Studies provide inconclusive results on the question whether loss of mental wellbeing is actually associated with decline in physical function in amyotrophic lateral sclerosis (ALS). The purpose of this study was to determine predictors of mental wellbeing in ALS. METHODS:In total, n = 330 ALS patients were...

journal_title：Journal of neurology

authors： Vázquez Medrano CR,Aho-Özhan HEA,Weiland U,Uttner I,Ludolph AC,Lulé D

更新日期：2020-12-01 00:00:00

abstract：:Eight cases of malignancies with concurrent motor neuron disease (MND), derived from an unselected population representing all cases of MND diagnosed during a 15-year period in two Italian provinces, were studied to verify the existence of paraneoplastic forms of the disease. No statistically significant association b...

journal_title：Journal of neurology

authors： Chiò A,Brignolio F,Meineri P,Rosso MG,Tribolo A,Schiffer D

更新日期：1988-07-01 00:00:00