Abstract：
:We wanted to determine the neurocognitive profile of adult patients with moyamoya disease prior to neurosurgical intervention. The experience of three United States medical centers, Columbia University, University of Illinois at Chicago, and the University of Texas Southwestern Medical Center at Dallas, were combined. Clinical data from adult patients (N = 29) referred for neuropsychological evaluation from 1996 to 2008 were reviewed. Neurocognitive functioning was assessed using standardized neuropsychological tests and all data were converted to z-scores. Memory, attention, processing speed, verbal memory, visuo-spatial, language, and executive functions were examined. Cognitive dysfunction was defined as performance in two or more cognitive domains 1.5 standard deviations below age-corrected normative means OR one or more cognitive domains two standard deviations below age-corrected normative means. Manual strength and dexterity, as well as depressive symptoms, were also assessed. Two-thirds of patients demonstrated neurocognitive dysfunction. A large proportion of patients were found to have pronounced cognitive dysfunction (>2 SD below the mean) on tests of processing speed (29%), verbal memory (31%), verbal fluency (26%) and executive function (25%). Manual strength and dexterity were also affected in many patients, with impairment found in 36-58% of patients. Twenty-eight percent of patients reported moderate to severe depression, but depressive symptoms did not correlate with neurocognitive findings. A large proportion of adults with moyamoya disease demonstrate disruption of neurocognition in a broad range of functions, particularly those mediated by subcortical and frontal regions. The pattern of deficits suggests a mechanism of diffuse small vessel disease possibly caused by chronic hypoperfusion.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Festa JR,Schwarz LR,Pliskin N,Cullum CM,Lacritz L,Charbel FT,Mathews D,Starke RM,Connolly ES,Marshall RS,Lazar RMdoi
10.1007/s00415-009-5424-8subject
Has Abstractpub_date
2010-05-01 00:00:00pages
806-15issue
5eissn
0340-5354issn
1432-1459journal_volume
257pub_type
杂志文章,多中心研究abstract：:Thirteen patients with subacute sclerosing panencephalitis (S.S.P.E.) at different stages of the disease were admitted for transfer factor treatment. The transfer factor was prepared from non-selected blood bank donors. The activity of the transfer factor was tested in patients with diseases other than S.S.P.E. and wa...
journal_title：Journal of neurology
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abstract：:Optic neuritis usually presents with rapid and gradual loss of vision that is either complete or incomplete, and typically associated with retro-orbital pain. To our knowledge there have been no documented reports of optic neuritis presenting with multiple episodes of amaurosis fugax, the sudden and transient loss of ...
journal_title：Journal of neurology
pub_type： 信件
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journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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journal_title：Journal of neurology
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
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journal_title：Journal of neurology
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journal_title：Journal of neurology
pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章
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更新日期：2001-07-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Journal of neurology
pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314498
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF03161079
更新日期：1999-09-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/BF00314416
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313992
更新日期：1986-02-01 00:00:00
