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Modulation of immunity in multiple sclerosis: a double-blind levamisole-placebo controlled study in 85 patients.

Abstract：

:Levamisole seems to regulate cell-mediated immunity by restoring T-cell function. Since a deficiency of T lymphocytes has been described by various authors in multiple sclerosis patients. Of the 85 patients involved in the trial, evaluation of functional and neurological scores was possible in 54 (32 with placebo and 22 with levamisole). The mean follow-up period was 2 years. This double-blind controlled study indicates that both neurological function and disability significantly deteriorated in the placebo-treated patients, but remained fairly stable in the levamisole-treated group. Since the difference between both groups was not significant, no levamisole effect was demonstrated on progression in multiple sclerosis. With the exception of one case of granulocytopenia (which had no clinical effect), no drug-related changes could be demonstrated. This contrasts with the general impression that this immunomodulator agent might be harmful to patients with multiple sclerosis. The fact that during this blind study both annual relapse rate and disability score remained more stable in treated patients with severe disability suggests that, while waiting for a more effective treatment, long-term levamisole therapy could be useful in patients with multiple sclerosis.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Gonsette RE,Demonty L,Delmotte P,Decree J,de Cock W,Verhaeghen H,Symoens J

doi

10.1007/BF00313411

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

65-72

issue

1

eissn

0340-5354

issn

1432-1459

journal_volume

228

pub_type

临床试验,杂志文章

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