Abstract：
:Twenty-nine cases of both clinically and neuropathologically diagnosed dementia with Lewy bodies (DLB) were retrospectively examined for autonomic symptoms. Twenty-eight cases showed some kind of autonomic dysfunction. Urinary incontinence (97 %) and constipation (83 %) were the two most common. Although urinary retention and episodic hypotension causing syncopal attacks were less common, the frequency was still high (28 % each). There were 18 cases (62 %) with severe autonomic failure. These 28 cases showed similar tendencies, with no significant differences between the subtypes of DLB (brainstem, limbic, and neocortical types or common and pure forms). We found that DLB of all pathological subtypes exhibits some kind and level of autonomic symptoms.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Horimoto Y,Matsumoto M,Akatsu H,Ikari H,Kojima K,Yamamoto T,Otsuka Y,Ojika K,Ueda R,Kosaka Kdoi
10.1007/s00415-003-1029-9keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
530-3issue
5eissn
0340-5354issn
1432-1459journal_volume
250pub_type
杂志文章abstract：BACKGROUND:Ultrafast brain MRI is required for uncooperative patients and time-critical diseases such as stroke because it reduces scan times and motion artifacts. This study investigated the clinical feasibility of a 1-min ultrafast brain MRI protocol for detecting intracranial abnormalities in restless and uncooperat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9149-4
更新日期：2019-02-01 00:00:00
abstract：:Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to b...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-018-8903-y
更新日期：2018-08-01 00:00:00
abstract：:Fifteen patients with Sneddon's syndrome presenting since 1979 were re-examined. After a neurological examination, an orienting test of mental ability as well as an electroencephalogram were performed in all patients. In 10 of the 15 patients computed tomography of the brain was performed, too. Preceding reports and t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314215
更新日期：1989-01-01 00:00:00
abstract：:Freezing of gait (FOG) is a disabling motor symptom experienced by a large proportion of patients with Parkinson's disease (PD). While it is known that FOG contributes to lower health-related quality of life (HRQoL), previous studies have not accounted for other important factors when measuring the specific impact of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7524-3
更新日期：2015-01-01 00:00:00
abstract：:We should like to emphasize the following points: 1. Apathy is defined here as a quantified and observable behavioral syndrome consisting in a quantitative reduction of voluntary (or goal-directed) behaviors; 2. Therefore, apathy occurs when the systems that generate and control voluntary actions are altered; 3. These...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-7012-5
更新日期：2006-12-01 00:00:00
abstract：:We explored how changes in visual attention impacted postural motor performance in healthy elders and adults post-stroke within a virtual reality environment, including when vestibular information was not perceptible. Visual dependence in 13 healthy (50-80 years) and 13 adults post-stroke (49-70 years) was assessed wi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6566-7
更新日期：2012-12-01 00:00:00
abstract：:This short review summarizes epilepsy papers published in the Journal of Neurology in 2009, covering pathophysiology (inflammation; propagation pathways), new treatments (oxcarbazepine in paediatrics; levetiracetam in status epilepticus), and non-seizure outcomes (violence; foetal/pregnancy). ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5740-z
更新日期：2010-11-01 00:00:00
abstract：:Fatigue is a common and frequently disabling symptom of multiple sclerosis (MS). The aim of this study was to develop the Fatigue index Kliniken Schmieder (FKS) for detecting motor fatigue in patients with MS using kinematic gait analysis. The FKS relies on the chaos theoretical term "attractor", which, if unchanged, ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7415-7
更新日期：2014-09-01 00:00:00
abstract：:Alemtuzumab is an anti-CD52 monoclonal antibody recently licensed for use in relapsing-remitting multiple sclerosis. Here, we report our experience of its use in neuromyelitis optica (NMO) spectrum disorders. A retrospective case review of patients treated with alemtuzumab in Cambridge, UK, was conducted to identify t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7925-y
更新日期：2016-01-01 00:00:00
abstract：:The article Diagnostic accuracy of a smartphone bedside test to assess the fixation suppression of the vestibulo‑ocular reflex: when nothing else matters, written by Florin Gandor, Manfred Tesch, Hannelore Neuhauser, Doreen Gruber, Hans‑Jochen Heinze, Georg Ebersbach and Thomas Lempert, was originally published electr...
journal_title：Journal of neurology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00415-020-10035-x
更新日期：2020-10-01 00:00:00
abstract：:Dopamine agonists have been proved safe and effective as initial therapy in early stages of Parkinson's disease. Prospective long-term clinical trials demonstrated that initial symptomatic treatment with a dopamine agonist is associated with a significantly reduced risk for motor complications in comparison with levod...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-004-1605-7
更新日期：2004-09-01 00:00:00
abstract：:Muscle samples obtained in patients with different neuromuscular diseases were stored at 0 degree C for periods of 6-12h and were subsequently frozen for histochemical processing. Compared to reference samples which had been immediately frozen, the individual test sections displayed different degrees of swelling of th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313934
更新日期：1984-01-01 00:00:00
abstract：:We have investigated how the abnormal head posture and motility in spasmodic torticollis interferes with ecological movements such as combined eye-to-foot whole-body reorientations to visual targets. Eight mildly affected patients and 10 controls voluntarily rotated eyes and body in response to illuminated targets of ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-6937-8
更新日期：2013-08-01 00:00:00
abstract：:A comparative study of clinical and morphological findings in three fatal cases of acute necrotizing hemorrhagic encephalomyelitis (ANHE) and hyperacute experimental allergic encephalomyelitis (HEAE) in rhesus monkeys is reported. In all cases ANHE was characterized clinically by definite prodromal respiratory infecti...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313109
更新日期：1979-08-01 00:00:00
abstract：RATIONALE:Phase I/II studies of autologous hematopoietic stem cell transplantation (HSCT) for multiple sclerosis ( MS) were initiated, based on results of experimental transplantation in animal models of multiple sclerosis and clinical observations in patients treated concomitantly for malignant disease. PATIENTS:Eigh...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00415-002-0800-7
更新日期：2002-08-01 00:00:00
abstract：:We report two adult Japanese sisters with L-2-hydroxy-glutaric aciduria (acidemia), both of whom were much older (aged 57, 47 years old) than previously reported patients (from neonate to 44 years old), and who presented with differing severity. Magnetic resonance imaging revealed typical subcortical white matter lesi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050367
更新日期：1999-05-01 00:00:00
abstract：:Natalizumab (TYSABRI(®)), a specific α4-integrin antagonist, is approved as a second-line treatment of relapsing-remitting MS (RRMS) patients who fail therapy with interferons or as first-line treatment of patients with highly active relapsing-remitting disease. Since the market introduction of natalizumab as a monoth...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6116-8
更新日期：2011-11-01 00:00:00
abstract：:Sixteen cerebrospinal fluid (CSF) specimens serially obtained during long-term follow-up of two patients with Devic's neuromyelitis optica (DNO) were compared with 65 CSF samples from patients with multiple sclerosis (MS). By statistical analysis, the CSF profile in DNO was found to differ from that observed in MS, ma...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314631
更新日期：1990-07-01 00:00:00
abstract：:This study aimed at an analysis of the release of Braintype and Heart-type Fatty Acid- Binding Proteins (B-FABP and HFABP) in acute ischaemic stroke and their potential value as neurobiochemical markers of brain damage. We investigated 42 consecutive patients admitted within 6 hours after ischaemic stroke. Serial veno...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0725-z
更新日期：2005-06-01 00:00:00
abstract：:Five patients are described who developed unilateral narrowing of the palpebral fissure that was aggravated by smiling. They had ischaemic lesions involving mainly the contralateral lenticulocapsular area. This rare but distinct symptom may be an action induced focal eyelid dystonia, and could be described as'smile-wi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170179
更新日期：2001-05-01 00:00:00
abstract：:Oxidative stress is involved in the pathogenesis of multiple system atrophy (MSA). Uric acid has an antioxidative effect. Our aim is to clarify the correlations between serum uric acid and MSA in Chinese population. A total of 234 patients with probable MSA and 240 age- and gender- matched healthy controls were includ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7006-z
更新日期：2013-10-01 00:00:00
abstract：:The neuropsychiatric symptoms and behavioral disorders affecting Parkinson's disease (PD) patients are common and disabling. A PD-specific interview-based 12-item scale, the Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), has been developed to assess the severity of neuropsychiatri...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-012-6490-x
更新日期：2012-11-01 00:00:00
abstract：:Parkinson's disease (PD) is characterised both clinically and pathologically by features that distinguish it from other parkinsonian disorders including, for instance, multiple system atrophy and progressive supranuclear palsy. The aetiologies of PD includes both genetic and environmental influences. Several single ge...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6016-y
更新日期：2011-05-01 00:00:00
abstract：:In patients with Parkinson's disease (PD) disturbances of mental state constitute some of the most difficult treatment challenges of advanced disease, often limiting effective treatment of motor symptoms and leading to increased disability and poor quality of life. This article provides an update on the current knowle...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-004-0483-3
更新日期：2004-07-01 00:00:00
abstract：:Long-term treatment studies with any antiparkinsonian drug are rather limited. Especially, double-blind, randomized and multicenter studies do not exist except for some rare exceptions. Nonetheless, such studies are mandatory to prove certain therapy regimens. This overview reports on the comparison between dopamine a...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007768
更新日期：2000-09-01 00:00:00
abstract：:Rodent oligodendrocytes have a unique susceptibility among glia to the lytic effects of complement, due in part to a deficiency in CD59 (protectin), a key surface inhibitor of the complement membrane attack complex (MAC). The possibility that shedding of CD59 by human oligodendrocytes contributes to complement-mediate...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00873519
更新日期：1994-08-01 00:00:00
abstract：:The objective was to identify factors associated with decisions made by patients with amyotrophic lateral sclerosis (ALS) to accept or decline non-invasive ventilation (NIV) and/or gastrostomy in a prospective population-based study. Twenty-one people with ALS, recruited from the South-East ALS Register who made an in...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7665-z
更新日期：2015-01-01 00:00:00
abstract：:The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...
journal_title：Journal of neurology
pub_type： 已发布勘误
doi：10.1007/s00415-020-10256-0
更新日期：2020-10-20 00:00:00
abstract：:The seasonal occurrence of relapses was analysed retrospectively in a group of 53 patients with treated dermatomyositis (DM) or polymyositis (PM). In DM, the incidence of both myositic and cutaneous relapses was highest in summer whereas in the PM group relapses was more evenly distributed throughout the seasons but l...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150200036
更新日期：2002-04-01 00:00:00
abstract：:Mutations in C19orf12 have been recently identified as the molecular genetic cause of a subtype of neurodegeneration with brain iron accumulation (NBIA). Given the mitochondrial localization of the gene product the new NBIA subtype was designated mitochondrial membrane protein-associated neurodegeneration. Frequent fe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6521-7
更新日期：2012-11-01 00:00:00
