当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy.

The costs of multiple sclerosis: a cross-sectional, multicenter cost-of-illness study in Italy.

Abstract：

OBJECTIVES:To estimate the socio-economic impact of multiple sclerosis (MS) in Italy. METHODS:Outpatients with MS were enrolled at 44 centres across Italy. Socio-demographic, clinical and resource utilization data were collected using a validated questionnaire. Each patient completed a weekly diary of expenses due to MS over a three-month period. Direct health care costs and indirect costs (lack of productivity for the patient and for caregivers) were assessed for the whole population and were compared among five groups, categorised by disease severity (EDSS score). An analysis of variance was carried out on socio-demographic variables. RESULTS:For the total population of 566 patients, the mean direct cost over three months was ITL 2,134,000, the mean indirect cost was ITL 7,775,000. Costs were significantly higher for male patients (p < 0.05) and showed a significant increase with increasing age (p < 0.0005), disease duration (p < 0.0005) and disease severity (p < 0.0005). Costs for patients in a progressive phase were significantly higher (p < 0.0005). There were no significant geographical differences among the regions of Italy. CONCLUSIONS:This study confirms that MS represents a high economic burden, with indirect costs greatly exceeding direct costs. Unpaid caregivers remain the culturally accepted mode of care for MS patients in Italy and this study illustrates the impact of their loss of earnings. As costs increase with disease progression, these findings suggest that treatment efforts should focus on patients in the early stages of MS, in order to slow down disease progression.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Amato MP,Battaglia MA,Caputo D,Fattore G,Gerzeli S,Pitaro M,Reggio A,Trojano M,Mu. S. I. C. Study Group.

doi

10.1007/pl00007858

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

152-63

issue

2

eissn

0340-5354

issn

1432-1459

journal_volume

249

pub_type

杂志文章,多中心研究

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Glatiramer acetate after mitoxantrone induction improves MRI markers of lesion volume and permanent tissue injury in MS.

    abstract：BACKGROUND:Glatiramer acetate (GA) therapy following brief, low-dose induction with mitoxantrone was safe and more effective than GA alone in suppressing inflammatory disease activity, as determined by a significant reduction in gadolinium (Gd)- enhancing MRI lesions, in a 15- month, randomized, single-blind study of r...

    journal_title：Journal of neurology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00415-008-0911-x

    authors： Arnold DL,Campagnolo D,Panitch H,Bar-Or A,Dunn J,Freedman MS,Gazda SK,Vollmer T

    更新日期：2008-10-01 00:00:00

  • Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.

    abstract：BACKGROUND:Anti-epileptic drug (AED) prophylaxis in the first-seven days post-traumatic brain injury (TBI) is known to reduce seizure frequency acutely. AED efficacy is equivalent; therefore, choice of AED may rest with their side-effects. We hypothesise that AEDs that impair balance will prolong recovery, shown by a l...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-09769-5

    authors： Harris L,Hateley S,Tsang KT,Wilson M,Seemungal BM

    更新日期：2020-06-01 00:00:00

  • Nerve sheath tumours.

    abstract：: ...

    journal_title：Journal of neurology

    pub_type： 评论,杂志文章

    doi：10.1007/s00415-018-9098-y

    authors： Robertson JA,Tallantyre EC

    更新日期：2018-12-01 00:00:00

  • Association between Synapsin III gene promoter polymorphisms and multiple sclerosis.

    abstract：:Although multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease, increasing evidence indicates that it is also an axonal pathology; indeed, studies of experimental allergic encephalitis showed that several neuronal proteins such as synapsins take part in the pathogenesis of the axonal dysfun...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-004-0293-7

    authors： Liguori M,Cittadella R,Manna I,Valentino P,La Russa A,Serra P,Trojano M,Messina D,Ruscica F,Andreoli V,Romeo N,Livrea P,Quattrone A

    更新日期：2004-02-01 00:00:00

  • Evaluation of the smooth pursuit tests in multiple sclerosis patients.

    abstract：:In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess th...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6014-0

    authors： Jozefowicz-Korczynska M,Pajor AM

    更新日期：2011-10-01 00:00:00

  • Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.

    abstract：:A haplotype marker consisting of three biallelic restriction fragment length polymorphism (RFLP) loci from the VH-2 variable gene family was examined in 124 families with sibling pairs concordant for multiple sclerosis, 178 unrelated patients and 159 unaffected controls to investigate the role of the immunoglobulin he...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00866919

    authors： Wood NW,Sawcer SJ,Kellar-Wood HF,Holmans P,Clayton D,Robertson N,Compston DA

    更新日期：1995-10-01 00:00:00

  • Dumb-bell sarcoma of the foramen jugulare with syringomyelia. A radio-induced tumour?

    abstract：:The clinicopathological findings of a 50-year-old man, who developed cervicothoracic syringomyelia at the age of 25 are presented. He was given radiation therapy at the age of 33. At the age of 57 he developed a foramen jugulare syndrome on the left, caused by a low grade leiomyosarcoma. Etiologically, the most attrac...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313150

    authors： Sieben G,Sieben-Praet M,De Reuck J,De Coster W,Remouchamps A,Roels H,vander Eecken H

    更新日期：1980-01-01 00:00:00

  • ALS and MMN mimics in patients with BSCL2 mutations: the expanding clinical spectrum of SPG17 hereditary spastic paraplegia.

    abstract：:Silver syndrome/SPG17 is a motor manifestation of mutations in the BSCL2 gene and usually presents as a complicated form of hereditary spastic paraplegia (HSP). We present clinical data, follow-up, and genetic results of seven patients with Silver syndrome/SPG17 including a family with a variable intrafamilial phenoty...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-016-8301-2

    authors： Musacchio T,Zaum AK,Üçeyler N,Sommer C,Pfeifroth N,Reiners K,Kunstmann E,Volkmann J,Rost S,Klebe S

    更新日期：2017-01-01 00:00:00

  • Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study.

    abstract：:Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to b...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-018-8903-y

    authors： Marshall I,Thrippleton MJ,Bastin ME,Mollison D,Dickie DA,Chappell FM,Semple SIK,Cooper A,Pavitt S,Giovannoni G,Wheeler-Kingshott CAMG,Solanky BS,Weir CJ,Stallard N,Hawkins C,Sharrack B,Chataway J,Connick P,Chandran S

    更新日期：2018-08-01 00:00:00

  • Improving survival in a large French ALS center cohort.

    abstract：:The aim of this work was to determine whether survival changed during 2002-2009 at a French amyotrophic lateral sclerosis (ALS) center. We included all patients with ALS who were seen consecutively at the center from January 2002-May 2009. Participants were followed from date of first visit through death, date of cens...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-011-6403-4

    authors： Gordon PH,Salachas F,Bruneteau G,Pradat PF,Lacomblez L,Gonzalez-Bermejo J,Morelot-Panzini C,Similowski T,Elbaz A,Meininger V

    更新日期：2012-09-01 00:00:00

  • Risk of Parkinson's disease after colectomy: longitudinal follow-up study using a national sample cohort.

    abstract：BACKGROUND AND PURPOSE:Parkinson's disease (PD) is a neurodegenerative disorder characterized by deposition of intraneural inclusion bodies in the brain as well as the enteric nervous system. Emerging concepts regarding the brain-gut axis have been proposed for neurological disorders. Thus, the present study investigat...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09617-1

    authors： Kim YJ,Lee CM,Kim S,Jang JW,Lee SY,Lee SH

    更新日期：2020-02-01 00:00:00

  • Malignant diseases among patients with multiple sclerosis.

    abstract：:The frequency of malignant diseases among 1866 living and 340 deceased multiple sclerosis (MS) patients was investigated in Finland. The study revealed a low prevalence (0.64%) and mortality (0.07%) rate of cancer among MS patients. The difference between MS patients and general population was significant. The highest...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313623

    authors： Palo J,Duchesne J,Wikström J

    更新日期：1977-10-07 00:00:00

  • A novel mutation at the N-terminal of SMN Tudor domain inhibits its interaction with target proteins.

    abstract：:Although most patients with spinal muscular atrophy (SMA) are homozygous for deletion of the SMN1 gene, some patients bear one SMN1 copy with a subtle mutation. Detection of such an intragenic mutation may be helpful not only in confirming diagnosis but also in elucidating functional domains of the SMN protein. In thi...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-006-0410-x

    authors： Kotani T,Sutomo R,Sasongko TH,Sadewa AH,Gunadi,Minato T,Fujii E,Endo S,Lee MJ,Ayaki H,Harada Y,Matsuo M,Nishio H

    更新日期：2007-05-01 00:00:00

  • Is atrial fibrillation associated with poor outcome after thrombolysis?

    abstract：:Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 +/...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5452-4

    authors： Sanák D,Herzig R,Král M,Bártková A,Zapletalová J,Hutyra M,Skoloudík D,Vlachová I,Veverka T,Horák D,Kanovský P

    更新日期：2010-06-01 00:00:00

  • Gait variability in Parkinson's disease: an indicator of non-dopaminergic contributors to gait dysfunction?

    abstract：:Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty peo...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5789-8

    authors： Lord S,Baker K,Nieuwboer A,Burn D,Rochester L

    更新日期：2011-04-01 00:00:00

  • The course of multiple sclerosis rewritten: a Norwegian population-based study on disease demographics and progression.

    abstract：OBJECTIVES:Over the past few decades, there has been an improvement in the rate of disability progression in multiple sclerosis (MS) patients, and most studies relate this evolvement to the introduction of disease-modifying therapies. However, several other factors have changed over this period, including access to MRI...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10279-7

    authors： Simonsen CS,Flemmen HØ,Broch L,Brunborg C,Berg-Hansen P,Moen SM,Celius EG

    更新日期：2020-10-22 00:00:00

  • Early diagnosis of dementia: which tests are indicated? What are their costs?

    abstract：:Dementia is reversible in a minority of patients, and these should be diagnosed but without subjecting the majority with irreversible disease to an excessive set of investigations. Should a battery of ancillary investigations be performed routinely in dementia? Or can these tests be carried out as clinically indicated...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s004150050311

    authors： van Crevel H,van Gool WA,Walstra GJ

    更新日期：1999-02-01 00:00:00

  • Paroxysmal raised intracranial pressure associated with spinal meningeal cysts.

    abstract：:Raised intracranial pressure in association with spinal meningeal cysts has rarely been reported. We describe four patients in whom evidence of paroxysmal raised intracranial pressure was found in association with spinal meningeal cysts. Cerebrospinal fluid diversion procedures have previously been shown to relieve lo...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0430-y

    authors： Shams PN,Goadsby PJ,Crockard HA,Casey AT,Plant GT

    更新日期：2005-03-01 00:00:00

  • Autoimmune disease in people with multiple sclerosis and their relatives: a systematic review and meta-analysis.

    abstract：:Additional autoimmune diseases in people with multiple sclerosis (MS) and their relatives have been studied many times. Studies have employed different designs, and yielded conflicting results. We performed a systematic review, and calculated overall risk of additional autoimmune diseases in people with MS and their f...

    journal_title：Journal of neurology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00415-012-6790-1

    authors： Dobson R,Giovannoni G

    更新日期：2013-05-01 00:00:00

  • Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.

    abstract：OBJECTIVE:To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. METHODS:We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative t...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10271-1

    authors： Firbank MJ,O'Brien JT,Durcan R,Allan LM,Barker S,Ciafone J,Donaghy PC,Hamilton CA,Lawley S,Lloyd J,Roberts G,Taylor JP,Thomas AJ

    更新日期：2020-10-21 00:00:00

  • Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia.

    abstract：:We recently reported findings that loss of cortical acetylcholinesterase (AChE) activity is greater in parkinsonian dementia than in Alzheimer's disease (AD). In this study we determined cognitive correlates of in vivo cortical AChE activity in patients with parkinsonian dementia (PDem, n = 11), Parkinson's disease wi...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0971-0

    authors： Bohnen NI,Kaufer DI,Hendrickson R,Ivanco LS,Lopresti BJ,Constantine GM,Mathis ChA,Davis JG,Moore RY,Dekosky ST

    更新日期：2006-02-01 00:00:00

  • The neurological sequelae of pandemics and epidemics.

    abstract：:Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestat...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-020-10261-3

    authors： Valerio F,Whitehouse DP,Menon DK,Newcombe VFJ

    更新日期：2020-10-26 00:00:00

  • Euro-Esli: a European audit of real-world use of eslicarbazepine acetate as a treatment for partial-onset seizures.

    abstract：:The Euro-Esli study was an exploratory pooled analysis of data from 14 European clinical practice studies, which was conducted to audit the real-world effectiveness, safety, and tolerability of eslicarbazepine acetate (ESL) as an adjunctive treatment for partial-onset seizures. Retention and effectiveness were assesse...

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-017-8618-5

    authors： Villanueva V,Holtkamp M,Delanty N,Rodriguez-Uranga J,McMurray R,Santagueda P

    更新日期：2017-11-01 00:00:00

  • Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy.

    abstract：:Familial amyloid polyneuropathy (FAP) is a progressive systemic autosomal dominant disease caused by pathogenic mutations in the transthyretin (TTR) gene. We studied clinical, electrophysiological, histopathological, and genetic characteristics in 15 (13 late-onset and two early-onset) patients belonging to 14 familie...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-013-7124-7

    authors： Dohrn MF,Röcken C,De Bleecker JL,Martin JJ,Vorgerd M,Van den Bergh PY,Ferbert A,Hinderhofer K,Schröder JM,Weis J,Schulz JB,Claeys KG

    更新日期：2013-12-01 00:00:00

  • Four novel mutations of the myelin protein zero gene presenting as a mild and late-onset polyneuropathy.

    abstract：:Inherited neuropathies caused by mutations of the major structural protein of peripheral myelin, myelin protein zero (MPZ), contribute to 5% of all cases of Charcot-Marie-Tooth disease (CMT). They can be divided into an early-onset neuropathy with symptoms prior to the stage of walking, and a late-onset neuropathy wit...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5624-2

    authors： Kleffner I,Schirmacher A,Gess B,Boentert M,Young P

    更新日期：2010-11-01 00:00:00

  • Clinical and electrophysiological studies of carbon disulphide polyneuropathy.

    abstract：:A clinical and electrophological study was performed on 30 patients with chronic carbon disulphide poisoning. Although the measurements of motor conduction velocity and of terminal latency were within the normal range in the subclinical stage, estimation of nerve excitability threshold showed distal motor hypoexcitabi...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313208

    authors： Vasilescu C,Florescu A

    更新日期：1980-01-01 00:00:00

  • Proton magnetic resonance spectroscopy of normal appearing white matter in familial and sporadic multiple sclerosis.

    abstract：OBJECTIVE:To assess metabolite levels in normal-appearing white matter in sporadic and familial multiple sclerosis (MS). METHODS:Using H-MRS and applying one voxel measure we assessed NAA/Cho, NAA/Cr and Cho/Cr ratios in 26 patients with sporadic and in 25 with familial MS and compared them with healthy subjects. RES...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0754-7

    authors： Siger-Zajdel M,Selmaj KW

    更新日期：2005-07-01 00:00:00

  • An unusual form of measles meningoencephalitis. A report of two cases.

    abstract：:Two patients are reported with a chronic progressive illness characterized by dementia, ataxia and spasticity. There were no myoclonic jerks and both had normal electroencephalograms (EEG). Pathological findings in three brain biopsies were those of viral meningoencephalitis with perivenous demyelination. Serological ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313048

    authors： Derakhshan I,Shafii A,Lotfi J,Abbassioun K,Scillian JJ

    更新日期：1979-09-01 00:00:00

  • Quantitative muscle MRI and ultrasound for facioscapulohumeral muscular dystrophy: complementary imaging biomarkers.

    abstract：OBJECTIVE:To assess the overlap of and differences between quantitative muscle MRI and ultrasound in characterizing structural changes in leg muscles of facioscapulohumeral muscular dystrophy (FSHD) patients. METHODS:We performed quantitative MRI and quantitative ultrasound of ten leg muscles in 27 FSHD patients and a...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-9037-y

    authors： Mul K,Horlings CGC,Vincenten SCC,Voermans NC,van Engelen BGM,van Alfen N

    更新日期：2018-11-01 00:00:00

  • Multifocal motor neuropathy: clinical and electrophysiological findings.

    abstract：:Multifocal motor neuropathy (MMN) can be differentiated from motor neuron disease by electrophysiological evidence of conduction block. To increase the probability of recording conduction block, we studied the whole nerve length including proximal segments in 84 patients with pure motor syndromes, using a special stim...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00873973

    authors： Jaspert A,Claus D,Grehl H,Neundörfer B

    更新日期：1996-10-01 00:00:00