Abstract：
:The frequency of malignant diseases among 1866 living and 340 deceased multiple sclerosis (MS) patients was investigated in Finland. The study revealed a low prevalence (0.64%) and mortality (0.07%) rate of cancer among MS patients. The difference between MS patients and general population was significant. The highest rate was found in the group from 40 to 49 years while in the general population the rate of cancer among MS patients tended to fall after the age of 50. The possible role of selenium, one of the antioxidants in the pathogenesis of MS and cancer, is discussed because recent data have shown a very high negative correlation between selenium and cancer death rates.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Palo J,Duchesne J,Wikström Jdoi
10.1007/BF00313623subject
Has Abstractpub_date
1977-10-07 00:00:00pages
217-22issue
3eissn
0340-5354issn
1432-1459journal_volume
216pub_type
杂志文章abstract：:Post-concussion symptoms (PCS) (such as headaches, irritability, anxiety, dizziness, fatigue and impaired concentration) are frequently experienced by patients who have sustained a minor head injury (MHI). The post-concussion syndrome has been defined as a clinical state where 3 or more symptoms persist for more than ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150050254
更新日期：1998-09-01 00:00:00
abstract：:The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran...
journal_title：Journal of neurology
pub_type： 已发布勘误
doi：10.1007/s00415-020-10256-0
更新日期：2020-10-20 00:00:00
abstract：:Neurological manifestations in pandemics frequently cause short and long-term consequences which are frequently overlooked. Despite advances in the treatment of infectious diseases, nervous system involvement remains a challenge, with limited treatments often available. The under-recognition of neurological manifestat...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-020-10261-3
更新日期：2020-10-26 00:00:00
abstract：:Moderate unilateral cerebral ischemia was produced by microembolism in 24 adult cats. Two million plastic microspheres with a diameter of 15 +/- 5 microns were injected into the left common carotid artery via the lingual artery. The physiological and metabolic responses to embolism were accessed by electrocorticograp...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313342
更新日期：1980-01-01 00:00:00
abstract：:The electrically elicited blink reflex was investigated in 25 patients with ischaemic lesions of the pons or the medulla oblongata. Only patients with a lesion on MRI appropriate to the clinical syndrome were included. Twenty patients had an infarction of the pons, bilateral in 5. Additional 5 patients had an infarcti...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00870670
更新日期：1993-11-01 00:00:00
abstract：:The safety and efficacy of intravenous thrombolysis (IVT) in dissection-related ischemic stroke (DRIS) has not been established. We sought to determine safety and recovery rates of IVT in DRIS using prospective, international, multicenter data and by conducting a comprehensive meta-analysis of reported case series. We...
journal_title：Journal of neurology
pub_type： 杂志文章,meta分析,多中心研究
doi：10.1007/s00415-015-7829-x
更新日期：2015-09-01 00:00:00
abstract：:Local administration of botulinum toxin (BoTx) inhibits presynaptic acetylcholine release. All cholinergically innervated muscles and glands can be paralyzed accordingly. Studies on the application of BoTx in multiple sclerosis have shown good results for focal spasticity, in particular, of the extremities. The first ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-1104-0
更新日期：2006-02-01 00:00:00
abstract：:Gait variability has potential utility as a predictive measure of dysfunction in Parkinson's disease (PD). Current understanding implicates non-dopaminergic pathways. This study investigated the explanatory characteristics of gait variability in PD on and off medication under single and dual task conditions. Fifty peo...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5789-8
更新日期：2011-04-01 00:00:00
abstract：:Hirayama's disease is a benign juvenile form of focal amyotrophy affecting the upper limbs. Previous studies have suggested that the disorder is a neck flexion induced cervical myelopathy. We report clinical and magnetic resonance imaging findings in nine patients with Hirayama's disease. Cervical imaging of seven pat...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050514
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:Epilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whethe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8979-4
更新日期：2018-10-01 00:00:00
abstract：:Cerebral venous thrombosis (CVT) affects mainly working-aged individuals. Functional recovery after CVT is generally considered good with about 3/4 of patients achieving short-term independence. However, vascular events, long-term functional outcome, and employment after CVT remain poorly investigated. We identified c...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7996-9
更新日期：2016-03-01 00:00:00
abstract：:The hereditary spastic paraplegias (HSPs) are a group of genetic conditions in which spastic paralysis of the legs is the principal clinical feature. This is caused by a relatively selective distal axonal degeneration involving the longest axons of the corticospinal tracts. Consequently, these conditions provide an op...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7598-y
更新日期：2015-07-01 00:00:00
abstract：:Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. However, dementia and hearing impairment present immense challenges in their own right, and their intersection in the auditory brain re...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-016-8208-y
更新日期：2016-11-01 00:00:00
abstract：:During a period of 42 months, we studied the prevalence of epilepsy in a specific health district, composing by four towns with 98,405 inhabitants older than 10 years. This has been accomplished by a two-phase cross-sectional study. The prevalence rate observed was 4.12/1000 inhabitants for all types of epilepsy. No s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170091
更新日期：2001-09-01 00:00:00
abstract：:Exercise therapy (ET) can be beneficial in disabled multiple sclerosis (MS) patients. Intermittent transcranial magnetic theta burst stimulation (iTBS) induces long-term excitability changes of the cerebral cortex and may ameliorate spasticity in MS. We investigated whether the combination of iTBS and a program of ET ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00415-011-5924-1
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:To develop specific diagnostic ultrasound (US) models for hereditary motor and sensory neuropathies (HMSN) in patients with primarily demyelinating or axonal polyneuropathies (PNP) according to standard nerve conduction studies (NCS) criteria. METHODS:Single-centre, examiner-blinded cross-sectional study in ac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8687-5
更新日期：2018-01-01 00:00:00
abstract：:Coenzyme Q10 (CoQ) was measured in serum and muscle of 17 patients with ophthalmoplegia plus (including 5 patients with Kearns-Sayre syndrome), in muscle of 9 patients with neurogenic atrophies, 5 patients with myositis, and 5 patients with progressive muscular dystrophies (including 1 patient with oculopharyngeal dys...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314404
更新日期：1989-02-01 00:00:00
abstract：:Quality of life is an important issue in the treatment of Parkinson's disease. Both general and disease specific quality of life scales are now being used in interventional trials. In the Sinemet CR First trial, the long-acting preparation was found to be superior to the immediate release preparation in several measur...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/pl00007735
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:An optimal management of vascular risk factors, associated with antithrombotic drugs and carotid surgery when appropriate, reduces the risk of a new vascular event after stroke. Although secondary prevention is not optimal in many patients in practice, the question of whether there is an improv...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0591-8
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Brain tumors cause significant morbidity and mortality due to rapid progression and high recurrence risks. Reliable biomarkers to improve diagnosis thereof are desirable. OBJECTIVE:This work aimed to identify panels of biomarkers for diagnostic purposes using cerebrospinal fluid (CSF)-based metabolomics. M...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09665-7
更新日期：2020-04-01 00:00:00
abstract：:The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebella...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0310-0
更新日期：2007-06-01 00:00:00
abstract：INTRODUCTION:Patients with blepharospasm in addition to involuntary contraction of the orbicularis oculi muscle also have non-motor symptoms (psychiatric, sleep, cognitive, and ocular). In this paper, we investigated the relationship of non-motor with motor symptoms and the total burden of non-motor symptoms in patient...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09484-w
更新日期：2019-11-01 00:00:00
abstract：:The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phos...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312524
更新日期：1975-01-01 00:00:00
abstract：:In multiple sclerosis (MS), randomly located demyelination lesions may involve a large part of the central nervous system and disturb oculomotor activity, including impairment of saccadic and pursuit systems. The aim of the work was to determine the frequency of smooth pursuit disturbances in MS patients and assess th...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6014-0
更新日期：2011-10-01 00:00:00
abstract：:During recent years, evidence has come up that bipedal locomotion is based on a quadrupedal limb coordination. A task-dependent neuronal coupling of upper and lower limbs allows one to involve the arms during gait but to uncouple this connection during voluntarily guided arm/hand movements. Hence, despite the evolutio...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6063-4
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:Amyotrophic lateral sclerosis type 8 (ALS8) is a familial form of motor neuron disease, with predominance of lower motor neuron degeneration, and is caused by mutation of the vesicle-associated membrane protein-associated protein B (VAPB). We aimed to compare the cognitive profile of patients with ALS8 and he...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09369-y
更新日期：2019-08-01 00:00:00
abstract：:The last 5 years have seen rapid progress in Parkinson’s disease (PD) genetics, with the publication of a series of large-scale genome wide association studies for PD, and evaluation of the roles of the LRRK2 and GBA genes in the aetiology of PD. We are beginning to develop a coherent picture of the interplay of Mende...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-013-7003-2
更新日期：2014-02-01 00:00:00
abstract：:Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of r...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9027-0
更新日期：2018-11-01 00:00:00
abstract：:Oculomotor dysfunction in Parkinson's disease (PD) is mainly characterized by a fragmentation of memory-guided gaze shifts (target is reached by several hypometric saccades). Since this phenomenon can also be observed in normal subjects, we scrutinized its pathophysiological significance in PD patients. We recorded ho...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0691-7
更新日期：2002-06-01 00:00:00
abstract：OBJECTIVE:To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A. METHODS:Short-term power spectral analysis of heart rate and systolic blood pressure variabilit...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0753-6
更新日期：2008-06-01 00:00:00
