Abstract:
OBJECTIVE:To assess metabolite levels in normal-appearing white matter in sporadic and familial multiple sclerosis (MS). METHODS:Using H-MRS and applying one voxel measure we assessed NAA/Cho, NAA/Cr and Cho/Cr ratios in 26 patients with sporadic and in 25 with familial MS and compared them with healthy subjects. RESULTS:In both MS groups NAA/Cho and NAA/Cr ratio were significantly lower than in healthy individuals whereas Cho/Cr ratio was higher in MS patients. In sporadic MS patients NAA/Cho and NAA/Cr ratios were lower, although not significantly, than in familial cases. The Cho/Cr ratio was similar in both MS groups. CONCLUSION:These results suggest that subtle differences in H-MRS measures corresponding to axonal rather than to myelin pathology might occur in sporadic and familial MS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Siger-Zajdel M,Selmaj KWdoi
10.1007/s00415-005-0754-7keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
830-2issue
7eissn
0340-5354issn
1432-1459journal_volume
252pub_type
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journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
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abstract::Neuromyelitis optica (NMO) is an uncommon, demyelinating disease that causes long-term disability in adults. Though much has recently been learned about its pathogenesis, there are still only a few studies regarding the epidemiology of NMO. The aim of the study was to describe the epidemiology of NMO among adults in t...
journal_title:Journal of neurology
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更新日期:2006-06-01 00:00:00
abstract:OBJECTIVES:Resistance to activated protein C (APC) is the most frequent cause of thrombophilia and a well known risk factor for deep and cerebral vein thrombosis. Its causative role in ischaemic stroke is still a matter of debate. We undertook this study to determine the prevalence of APC-resistance in a cohort of cons...
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pub_type: 临床试验,杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s00415-004-0351-1
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-009-0034-z
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00313895
更新日期:1985-01-01 00:00:00
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6721-1
更新日期:2013-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150170023
更新日期:2001-12-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00415-006-0356-z
更新日期:2007-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1978-09-12 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10140-x
更新日期:2021-01-01 00:00:00