当前位置： SCI文献检索 > JOURNAL OF NEUROLOGY期刊下所有文献 > Tissue damage within normal appearing white matter in early multiple sclerosis: assessment by the ratio of T1- and T2-weighted MR image intensity.

Tissue damage within normal appearing white matter in early multiple sclerosis: assessment by the ratio of T1- and T2-weighted MR image intensity.

Abstract：

:Histopathological and magnetic resonance imaging (MRI) studies have shown white matter (WM) damage in early stages of multiple sclerosis (MS) beyond the apparent T2-hyperintense lesions. These changes in normal appearing WM (NAWM) are important with regard to the clinical picture and prognosis. However, the detection of changes within NAWM has so far required special imaging techniques commonly not available in clinical routine and, hence, at large scale. The purpose of this study was to detect MS-related damage of NAWM by conventional MRI. As, within NAWM, the myelin content mainly drives the T1-weighted (T1w) signal, we scaled it by the T2w signal. We tested the hypothesis that the mean T1w/T2w ratio of NAWM is decreased in MS compared to healthy controls (HC) and that it correlates with clinical measures. We developed a pipeline to determine the individual mean values of this ratio within NAWM. We studied 244 patients in early disease stages of MS (mean age 37 ± 10 years, mean disease duration 3.1 ± 2.3, Expanded Disability Status Scale 1.3 ± 1), and 78 HC (mean age 31 ± 8 years). Compared to HC, the mean T1w/T2w ratio was lowered in the patient group (P < 0.001). The difference remained significant after restricting the analysis to patients with a disease duration of 5 years or less and without disease modifying drugs. Our measures also correlated with clinical scores. We believe that the mean T1w/T2w ratio is a promising candidate to assess MS-related tissue damage within NAWM at large scale.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Beer A,Biberacher V,Schmidt P,Righart R,Buck D,Berthele A,Kirschke J,Zimmer C,Hemmer B,Mühlau M

doi

10.1007/s00415-016-8156-6

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1495-502

issue

8

eissn

0340-5354

issn

1432-1459

pii

10.1007/s00415-016-8156-6

journal_volume

263

pub_type

杂志文章

相关文献

JOURNAL OF NEUROLOGY文献大全
  • Essential familial myoclonus.

    abstract：:From a family with essential familial myoclonus, 150 members in eight generations were studied. Twenty-five of them suffered from myoclonus of varying severity. The findings in routine examinations of blood, urine and cerebrospinal fluid, EEG and skull radiographs were normal. Therapeutic trials did not produce lastin...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313626

    authors： Przuntek H,Muhr H

    更新日期：1983-01-01 00:00:00

  • Primary lateral sclerosis and the amyotrophic lateral sclerosis-frontotemporal dementia spectrum.

    abstract：AIM:To investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum of diseases. METHODS:Comprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-8917-5

    authors： Agarwal S,Highton-Williamson E,Caga J,Matamala JM,Dharmadasa T,Howells J,Zoing MC,Shibuya K,Geevasinga N,Vucic S,Hodges JR,Ahmed RM,Kiernan MC

    更新日期：2018-08-01 00:00:00

  • Crossed aphasia following cerebral infarction in a right-handed patient with atypical cerebral language dominance.

    abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-8901-0

    authors： Tan X,Guo Y,Dun S,Sun H

    更新日期：2018-07-01 00:00:00

  • The metabolic and endocrine characteristics in spinal and bulbar muscular atrophy.

    abstract：OBJECTIVE:Spinal and bulbar muscular atrophy (SBMA) is caused by an abnormal expansion of the CAG repeat in the androgen receptor gene. This study aimed to systematically phenotype a German SBMA cohort (n = 80) based on laboratory markers for neuromuscular, metabolic, and endocrine status, and thus provide a basis for ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-8790-2

    authors： Rosenbohm A,Hirsch S,Volk AE,Grehl T,Grosskreutz J,Hanisch F,Herrmann A,Kollewe K,Kress W,Meyer T,Petri S,Prudlo J,Wessig C,Müller HP,Dreyhaupt J,Weishaupt J,Kubisch C,Kassubek J,Weydt P,Ludolph AC

    更新日期：2018-05-01 00:00:00

  • Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit.

    abstract：BACKGROUNDS:Wake-Up Stroke (WUS) patients are generally excluded from thrombolytic therapy (rTPA) due to the unknown time of stroke onset. This study aimed to investigate the effects of rTPA in WUS patients during every day clinical scenarios, by measuring ischemic lesion volume and functional outcomes compared to non-...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09603-7

    authors： Furlanis G,Ajčević M,Buoite Stella A,Cillotto T,Caruso P,Ridolfi M,Cova MA,Naccarato M,Manganotti P

    更新日期：2020-03-01 00:00:00

  • The impact of the initial severity on later outcome: retrospective analysis of a large cohort of botulinum toxin naïve patients with idiopathic cervical dystonia.

    abstract：BACKGROUND:The aim of study was to demonstrate that the first three injections of botulinum neurotoxin type A (BoNT/A) appear to be less effective in botulinum toxin naïve patients with idiopathic cervical dystonia (CD) with mild symptoms and low severity scores (TSUI-scores) at onset of BoNT/A-therapy compared to pati...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-020-10128-7

    authors： Hefter H,Samadzazeh S,Rosenthal D

    更新日期：2021-01-01 00:00:00

  • Diagnosis of chronic neuropathy.

    abstract：:Chronic neuropathy is the most frequent condition affecting the peripheral nervous system. It includes symmetrical polyneuropathies, multifocal mononeuropathies, mononeuropathies and radiculopathies. Mononeuropathies are mainly due to compression or entrapment and are not discussed in this review, which focuses on pol...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s004150050326

    authors： Léger JM

    更新日期：1999-03-01 00:00:00

  • T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians.

    abstract：BACKGROUND:Putaminal iron deposition is a histopathological feature of multiple system atrophy (MSA), which is not observed in patients with idiopathic Parkinson's disease (PD). T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-006-0496-1

    authors： von Lewinski F,Werner C,Jörn T,Mohr A,Sixel-Döring F,Trenkwalder C

    更新日期：2007-09-01 00:00:00

  • Neurocognitive dysfunction in adult moyamoya disease.

    abstract：:We wanted to determine the neurocognitive profile of adult patients with moyamoya disease prior to neurosurgical intervention. The experience of three United States medical centers, Columbia University, University of Illinois at Chicago, and the University of Texas Southwestern Medical Center at Dallas, were combined....

    journal_title：Journal of neurology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00415-009-5424-8

    authors： Festa JR,Schwarz LR,Pliskin N,Cullum CM,Lacritz L,Charbel FT,Mathews D,Starke RM,Connolly ES,Marshall RS,Lazar RM

    更新日期：2010-05-01 00:00:00

  • [The occurrence of diabetes mellitus, diabetes insipidus, optic atrophy and neurogenic deafness in one patient (author's transl)].

    abstract：:Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314325

    authors： Foerster K,Spranger J,Beyer J,Regli F

    更新日期：1975-08-04 00:00:00

  • The neurological update: therapies for cerebellar ataxias in 2020.

    abstract：:Cerebellar ataxias (CAs) represent a heterogeneous group of sporadic or inherited disorders. The clinical spectrum of CAs is continuously expanding. Our understanding of the mechanisms leading to the clinical deficits has improved over these last decades, in particular thanks to progress in genetics, neuroimaging and ...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-020-09717-3

    authors： Gandini J,Manto M,Bremova-Ertl T,Feil K,Strupp M

    更新日期：2020-04-01 00:00:00

  • Brain-stem haematoma with complete recovery.

    abstract：:A case of CT-diagnosed brain-stem haematoma associated with signs of dorsal medullary involvement is reported. The patient recovered completely within 1 month. ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00313834

    authors： Cappa SF,Riva M,Sterzi R,Canepari C,Delzanno GB

    更新日期：1985-01-01 00:00:00

  • Lateralized microstructural changes in early-stage Parkinson's disease in anterior olfactory structures, but not in substantia nigra.

    abstract：:Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized mi...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-017-8555-3

    authors： Joshi N,Rolheiser TM,Fisk JD,McKelvey JR,Schoffer K,Phillips G,Armstrong M,Khan MN,Leslie RA,Rusak B,Robertson HA,Good KP

    更新日期：2017-07-01 00:00:00

  • Myasthenia gravis: a clinical-immunological update.

    abstract：:Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine receptors cause fatigable weakness of skeletal muscles. In the rest, a variable proportion possesses antibodies to muscle-specific tyrosine...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-015-7963-5

    authors： Binks S,Vincent A,Palace J

    更新日期：2016-04-01 00:00:00

  • Comparative analysis of intrathecal antibody synthesis and DNA amplification for the diagnosis of cytomegalovirus infection of the central nervous system in AIDS patients.

    abstract：:We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus (CMV) infection. The patients were grouped according to clinical criteria as probable CMV encephalitis/polyradiculomyelitis, CMV ret...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00900957

    authors： Weber T,Beck R,Stark E,Gerhards J,Korn K,Haas J,Lüer W,Jahn G

    更新日期：1994-06-01 00:00:00

  • Early detection of post-traumatic olivary hypertrophy by MRI.

    abstract：:Two patients are described, in whom MRI detected unilateral signal abnormalities in the region of the inferior olivary nuclei, suggesting an early stage of olivary hypertrophy. MRI was performed 4 and 7 weeks respectively after traumatic brain-stem injury. Palatal myoclonus was concomitantly observed in one patient, w...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00867352

    authors： Birbamer G,Buchberger W,Kampfl A,Aichner F

    更新日期：1993-07-01 00:00:00

  • Do the effects measured by intraoperative and postoperative STN macrostimulation in Parkinson's disease match?

    abstract：:The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-010-5543-2

    authors： Xie J,Adamec D,Decullier E,Bin-Dorel S,Mertens P,Polo G,Poisson A,Broussolle E,Thobois S

    更新日期：2010-09-01 00:00:00

  • Stroke in younger patients: the heart of the matter.

    abstract：:Stroke in young adults is not a rare entity, and often provides difficult management decisions for neurologists. The knowledge gained from stroke in older adults does not transfer easily to this younger group given the different causes of stroke observed. Cardiac causes of stroke are common in this group, but often co...

    journal_title：Journal of neurology

    pub_type： 杂志文章,评审

    doi：10.1007/s00415-010-5647-8

    authors： Cotter PE,Belham M,Martin PJ

    更新日期：2010-11-01 00:00:00

  • Risk factors for critical illness polyneuromyopathy.

    abstract：:Although numerous clinical, laboratory, and pharmacological variables have been reported as significant risk factors for critical illness polyneuromyopathy (CIPM), there is still no consensus on the aetiology of this condition. Objectives of the study were to assess the clinical and electrophysiological incidence and ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0654-x

    authors： Bednarík J,Vondracek P,Dusek L,Moravcova E,Cundrle I

    更新日期：2005-03-01 00:00:00

  • "Pusher syndrome" following cortical lesions that spare the thalamus.

    abstract：:Stroke patients with "pusher syndrome" show severe misperception of their own upright body orientation although visual-vestibular processing is almost intact. This dissociation argues for a second graviceptive system in humans for the perception of body orientation. Recent studies revealed that the posterior thalamus ...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-005-0025-7

    authors： Johannsen L,Broetz D,Naegele T,Karnath HO

    更新日期：2006-04-01 00:00:00

  • Coordination and timing deficits in speech and swallowing in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS).

    abstract：BACKGROUND:Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a rare early onset neurodegenerative disease that typically results in ataxia, upper motor neuron dysfunction and sensorimotor peripheral neuropathy. Dysarthria and dysphagia are anecdotally described as key features of ARSACS but the natu...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-8950-4

    authors： Vogel AP,Rommel N,Oettinger A,Stoll LH,Kraus EM,Gagnon C,Horger M,Krumm P,Timmann D,Storey E,Schöls L,Synofzik M

    更新日期：2018-09-01 00:00:00

  • Platelet-derived extracellular vesicles in Huntington's disease.

    abstract：:The production and release of extracellular vesicles (EV) is a property shared by all eukaryotic cells and a phenomenon frequently exacerbated in pathological conditions. The protein cargo of EV, their cell type signature and availability in bodily fluids make them particularly appealing as biomarkers. We recently dem...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-9022-5

    authors： Denis HL,Lamontagne-Proulx J,St-Amour I,Mason SL,Weiss A,Chouinard S,Barker RA,Boilard E,Cicchetti F

    更新日期：2018-11-01 00:00:00

  • The G79A polymorphism of protein Z gene is an independent risk factor for cerebral venous thrombosis.

    abstract：BACKGROUND AND PURPOSE:Protein Z (PZ), a vitamin Kdependent protein, plays a role in inhibiting coagulation. Its plasma level or PZ gene polymorphisms have been discussed as risk factors for stroke with conflicting results reported between various studies. Only one of these polymorphisms was studied in a cohort of pati...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-008-0958-8

    authors： Le Cam-Duchez V,Bagan-Triquenot A,Barbay V,Mihout B,Borg JY

    更新日期：2008-10-01 00:00:00

  • Progressive myoclonus epilepsy in Down syndrome patients with dementia.

    abstract：:This study aimed to elucidate the natural history of senile myoclonic epilepsy, a type of myoclonic epilepsy associated with Alzheimer's disease in adult Down syndrome patients. Twelve Down syndrome patients over the age of 40 years with myoclonic epilepsy and Alzheimer's disease underwent clinical, neuropsychological...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7376-x

    authors： d'Orsi G,Specchio LM,Apulian Study Group on Senile Myoclonic Epilepsy.

    更新日期：2014-08-01 00:00:00

  • A 34-year longitudinal study on long-term cardiac outcomes in DM1 patients with normal ECG at baseline at an Italian clinical centre.

    abstract：:Cardiac conduction and/or rhythm abnormalities (CCRA) are the most frequent and life-threatening complications in DM1. In order to determine prevalence, incidence, characteristics, age of onset and predictors of CCRA, CCRA progression and sudden cardiac death (SCD) in DM1, we collected ECG/24hECG-Holter data from a ye...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-018-8773-3

    authors： Bucci E,Testa M,Licchelli L,Frattari A,El Halabieh NA,Gabriele E,Pignatelli G,De Santis T,Fionda L,Vanoli F,Morino S,Garibaldi M,Di Pasquale A,Vanacore N,Botta A,Antonini G

    更新日期：2018-04-01 00:00:00

  • Leukoencephalopathy, cerebral calcifications and cysts: a family study.

    abstract：:We present a clinical, neuro-radiological and genetic study on a family with members suffering from an autosomal dominantly inherited syndrome characterised by epilepsy, cerebral calcifications and cysts, bone abnormalities; progressive neuro-cognitive deterioration and paranasal sinusitis. This syndrome shares severa...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-014-7393-9

    authors： Karlinger K,Tárnoki ÁD,Tárnoki DL,Polvi A,Lehesjoki AE,Kelemen A,Szegedi L,Turányi E,Kamondi A,Szűcs A

    更新日期：2014-10-01 00:00:00

  • Intrathecal synthesis of specific IgG in syphilitic patients with human immunodeficiency virus 1 infection.

    abstract：:Intrathecal synthesis of immunoglobulin G (IgG) specific to Treponema pallidum, ssp. pallidum, or to the human immunodeficiency virus 1 (HIV-1) was investigated in patients with contemporary treponemal and HIV-1 infections. Using a T. pallidum and an HIV-1 IgG enzyme-linked immunosorbent assay, specific antibody units...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00314359

    authors： Müller F,Moskophidis M,Schmitz H

    更新日期：1988-03-01 00:00:00

  • Prognostic value of amyloid PET scan in normal pressure hydrocephalus.

    abstract：:Amyloid positron emission tomography ([18F] florbetaben (FBB) PET) can be used to determine concomitant Alzheimer's disease (AD) in idiopathic normal pressure hydrocephalus (iNPH) patients. FBB PET scans and the tap test were performed in 31 patients with clinically suspected iNPH, and amyloid positive (iNPH/FBB+) and...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-017-8650-5

    authors： Jang H,Park SB,Kim Y,Kim KW,Lee JI,Kim ST,Lee KH,Kang ES,Choe YS,Seo SW,Kim HJ,Kim YJ,Yoon CW,Na DL

    更新日期：2018-01-01 00:00:00

  • Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease.

    abstract：:Regional cerebral glucose metabolism (rCMRGlc) and dopamine D2 receptor binding were measured in a 31-year-old, severely affected, untreated patient with Wilson's disease of 3 years' duration using positron emission tomography and 18F-deoxyglucose and 18F-methylspiperone ([18F]MSP), respectively. There was a severe re...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/BF00920620

    authors： Schlaug G,Hefter H,Nebeling B,Engelbrecht V,Weiss P,Stöcklin G,Seitz RJ

    更新日期：1994-10-01 00:00:00

  • Approach to an experimental model of Mal de Debarquement Syndrome.

    abstract：INTRODUCTION:Mal de Debarquement Syndrome (MdDS) is the rare condition of enduring rocking sensations and subjective unsteadiness following a lengthy exposure to passive motion. The pathogenesis of MdDS is unknown and the available treatment is limited. Here, we developed an experimental model of MdDS that may facilita...

    journal_title：Journal of neurology

    pub_type： 杂志文章

    doi：10.1007/s00415-019-09345-6

    authors： Schepermann A,Bardins S,Penkava J,Brandt T,Huppert D,Wuehr M

    更新日期：2019-09-01 00:00:00