Abstract：
:Acute relapses of multiple sclerosis (MS) are treated with intravenous methylprednisolone (IVMP), which speeds recovery from exacerbation. It is known that IVMP suppresses the immunological activation which occurs during an acute attack of MS. However, the specific target genes affected by this therapy remain obscure. A cDNA microarray for 448 genes was used to identify the target genes in IVMP therapy. Total RNA was isolated from peripheral blood mononuclear cells derived from six MS patients immediately before and after completion of therapy. IVMP significantly reduced mRNA levels for T-cell-specific transcription factor 7 (p=0.02), T-cell-specific protein-tyrosine kinase (p=0.02), T-cell surface glycoprotein CD5 (p=0.05) and interferon-stimulated gene factor 3 gamma subunit (p=0.04). Significantly increased expression was found for eosinophil-derived neurotoxin (p=0.05). The suppression of expression of genes associated with T-cell differentiation and antigen-specific T-cell activation detected in this study may contribute to the beneficial effect of MP in relapses of MS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Airla N,Luomala M,Elovaara I,Kettunen E,Knuutila S,Lehtimäki Tdoi
10.1007/s00415-004-0516-ykeywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1215-9issue
10eissn
0340-5354issn
1432-1459journal_volume
251pub_type
杂志文章abstract：BACKGROUND:Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of Meynert and thus to decreased cholinergic tonus in the brain. The transcription of endothelial nitric oxide synthase depends on an adequate cholinergic innervation of microvessels and vasoregulative abnormalities have been reported in...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s00415-005-0926-5
更新日期：2006-01-01 00:00:00
abstract：:Mutations in C19orf12 have been recently identified as the molecular genetic cause of a subtype of neurodegeneration with brain iron accumulation (NBIA). Given the mitochondrial localization of the gene product the new NBIA subtype was designated mitochondrial membrane protein-associated neurodegeneration. Frequent fe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6521-7
更新日期：2012-11-01 00:00:00
abstract：:Various parameters of histamine metabolism were studied in patients with migraine, cluster headache and chronic paroxysmal hemicrania. These included urinary excretion of radioactivity and of 14C histamine and its metabolites, exhaled 14CO2 and fecal radioactivity after oral as well as subcutaneous administration of r...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312944
更新日期：1977-09-12 00:00:00
abstract：:In recent years, it has been widely recognised that modern doctors are not receiving the training they need to provide appropriate and effective palliative care. Deficiencies in care have been reported in several formal studies and, anecdotally, in many professional and popular lay publications. Doctors themselves hav...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00007722
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Dysarthria may be classified as flaccid, spastic, ataxic, hypokinetic, choreatic, dystonic, or mixed. We hypothesized that in routine neurological practice the reliability and accuracy of perceptual analysis alone in the classification of dysarthria is low and that this classification is mainly based on the ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0978-4
更新日期：2008-10-01 00:00:00
abstract：:Anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis is an acute neurological disorder affecting children and adults. We aimed to compare the clinical characteristics, treatments, and outcomes between children and adults with anti-NMDAR encephalitis and to assess the probable risk factors. In this observational stu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8282-1
更新日期：2016-12-01 00:00:00
abstract：:The prevalence of clinical and electrophysiological signs of peripheral nerve disease was evaluated in 151 patients with chronic obstructive pulmonary disease. Patients with concomitant disorders affecting the peripheral nervous system were excluded. Thirty patients had clinical signs of a mild sensorimotor and distal...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314624
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Epilepsy in children negatively impacts on caregiver quality of life (QOL). The study aimed to evaluate the relationships between patient factors [demographics, clinical factors, health-related quality of life (HRQL)], contextual factors (socio-economic factors), caregiver mood, and caregiver QOL, and whethe...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8979-4
更新日期：2018-10-01 00:00:00
abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
abstract：:In contrast to other neurodegenerative diseases, sporadic Creutzfeldt-Jakob disease (sCJD) is rarely diagnosed in patients older than 75 years. Data describing the characteristics of sCJD in the very old are rare and inconclusive. Therefore, a historical cohort study was designed to evaluate clinical, cerebrospinal fl...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-014-7283-1
更新日期：2014-05-01 00:00:00
abstract：:Stiff-person syndrome (SPS) is a rare condition of progressive muscular rigidity and spasm, frequently accompanied by other autoimmune conditions, an association which has been further strengthened by the discovery of anti-GAD antibodies and the response of SPS to immunotherapies. Intravenous immunoglobulin (IVIg) is ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6015-z
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Multiple sclerosis (MS) notably affects adults of working age. For persons with MS (PwMS), being employed enhances their quality of life and it may be regarded as an indicator of overall functioning. Thus, ensuring work participation in PwMS is of general public health interest. OBJECTIVE:To examine relevan...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09973-3
更新日期：2020-10-01 00:00:00
abstract：:Familial paroxysmal exercise-induced dyskinesia (PED) is a rare movement disorder that is mostly caused by mutations in the solute carrier family 2, member 1 (SLC2A1) gene and inherited in an autosomal dominant manner. Clinical, laboratory, and genetic studies were performed in three family members. The proband's symp...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7441-5
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Progression of parkinsonian motor impairment is usually rapid and relentless in multiple system atrophy (MSA). However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in M...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0617-2
更新日期：2005-01-01 00:00:00
abstract：:Five patients are described who developed unilateral narrowing of the palpebral fissure that was aggravated by smiling. They had ischaemic lesions involving mainly the contralateral lenticulocapsular area. This rare but distinct symptom may be an action induced focal eyelid dystonia, and could be described as'smile-wi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170179
更新日期：2001-05-01 00:00:00
abstract：:A man, aged 46, who had been taking Clioquinol in high doses for a long period, developed a characteristic neurological syndrome of subacute myelo-optic neuropathy rather abruptly. Electron microscopical examination of the muscle biopsy, obtained five months after the onset of the disease, revealed severe degenerative...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：
更新日期：1977-05-13 00:00:00
abstract：:Frequent serial EEG investigations of three patients with neuropathologically confirmed Creutzfeldt-Jakob disease lasting 13, 24 and 68 weeks revealed typical periodic activity of short duration with stereotyped bilateral sharp waves at the 7th, 8th, and 12th week, respectively, after the onset of symptoms. During the...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00328506
更新日期：1989-12-01 00:00:00
abstract：:Forty-four patients (mean age 66, SD 8 years) with either clinical evidence of a focal lacunar syndrome (n = 36) or with disorders of memory or gait (n = 8) in the presence of a lacunar infarct on CT were studied for cognitive functioning and for the presence of white matter lesions on MRI. MR images were assessed by ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444014
更新日期：1996-02-01 00:00:00
abstract：:We investigated the effect of chronic mechanical compression of the cervical spinal cord on the number of spinal accessory motoneurons in 25 tiptoe-walking Yoshimura mice. The animals had calcified deposits in the atlantoaxial membrane at the C1-C2 vertebral level, compressing the spinal cord posterolaterally. Motoneu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050076
更新日期：1997-04-01 00:00:00
abstract：:The phase III, multicenter, randomized, placebo-controlled PreCISe trial assessed glatiramer acetate (GA) effects in patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS). To assess the neuroprotective effect of GA in a subset of patients in the PreCISe trial, we used proton magnetic ...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00415-013-6903-5
更新日期：2013-07-01 00:00:00
abstract：:Recent studies reported mutations in the gene encoding the proline-rich transmembrane protein 2 (PRRT2) to be causative for paroxysmal kinesigenic dyskinesia (PKD), PKD combined with infantile seizures (ICCA), and benign familial infantile seizures (BFIS). PRRT2 is a presynaptic protein which seems to play an importan...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-012-6777-y
更新日期：2013-05-01 00:00:00
abstract：:A night-time polygraphic sleep recording with continuous HbSaO2 monitoring was performed in 11 chair-bound Duchenne muscular dystrophy patients with severe restrictive lung disease but with blood gas values within normal limits when awake. No abnormalities of sleep pattern were detected. Nocturnal sleep did not have s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314896
更新日期：1989-10-01 00:00:00
abstract：OBJECTIVE:There exist controversial and discrepant results on the risk of spontaneous abortions and teratogenesis induced by interferon treatment in people with MS.Aim of this study is to evaluate risks of the administration of INFbeta related not only to the foetus, but also to children development up to 12-months dev...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0909-4
更新日期：2008-08-01 00:00:00
abstract：INTRODUCTION:Intracranial lipomas are rare, mostly congenital lesions. Sporadic case reports suggest an association with focal epilepsy. METHODS:All admissions to our epilepsy monitoring unit who had had brain MRI were reviewed for intracranial lipomas during 6 consecutive years. RESULTS:Five patients with intracrani...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0065-7
更新日期：2006-05-01 00:00:00
abstract：:We should like to emphasize the following points: 1. Apathy is defined here as a quantified and observable behavioral syndrome consisting in a quantitative reduction of voluntary (or goal-directed) behaviors; 2. Therefore, apathy occurs when the systems that generate and control voluntary actions are altered; 3. These...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-7012-5
更新日期：2006-12-01 00:00:00
abstract：:Thinning of the retinal nerve fiber layer (RNFL) of clinically unaffected eyes is seen in patients with multiple sclerosis (MS). It is uncertain when this thinning occurs, and whether ongoing RNFL loss can be measured over time with optical coherence tomography (OCT). Using time-domain OCT, we studied 34 patients with...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5467-x
更新日期：2010-07-01 00:00:00
abstract：:Parkinson's disease (PD) is preceded by a premotor phase of unknown duration. Dopaminergic degeneration during this phase may lead to subtle cognitive and behavioural changes, such as decreased novelty seeking. Consequently, premotor subjects might be most comfortable in jobs that do not require optimal dopamine level...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7828-y
更新日期：2015-09-01 00:00:00
abstract：:Activation studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) represent a powerful tool to study the functional anatomy of Parkinson's disease (PD). Activation studies offer the opportunity to study regional cerebral function in man in vivo under different conditions with ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-003-1103-1
更新日期：2003-02-01 00:00:00
abstract：:Autonomic nervous system (ANS) involvement is frequently found in Parkinson's disease (PD), but its causal relationship to the disease itself and its medication is unclear. We evaluated the effects of PD medications on cardiovascular ANS functions. Heart rate (HR) responses to normal and deep breathing, the Valsalva m...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s004150070075
更新日期：2000-11-01 00:00:00
abstract：:In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1 h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid. These features suggest that hyperpyrexia in this syndrome may be caused by heat production from uncoupled phosphorylation in muscle and imply t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00718024
更新日期：1987-12-01 00:00:00
