Abstract:
:The fluctuation in daily performance of Parkinson patients on long-term L-dopa therapy is known as the so called "off-on" phenomenon. Cotzias et al. found that a low protein diet is able to control this phenomenon in patients taking L-dopa alone but not in those receiving a combination of L-dopa and decarboxylase inhibitor. The author's hypothesis was based on the competition between the alimentary aminoacids and L-dopa for transport to the brain ganglia. In our attempt to prove the findings of Cotzias group we tested the influence of a low protein diet on 23 Parkinson patients manifesting the "off-on" phenomenon. All had been pretreated with L-dopa for 5--8 years and taking dopa DI for a minimum of 3 years. The protein intake was limited to 25 g/day (which is less than 0.5 g/kg body weight) for 1--4 months. In 6 cases there was a marked improvment with reduction of the "off-on" effect, and in one it disappeared completely. A distinct improvment of general capability was seen in the other 5 cases, and an objective improvment of the symptoms was noted, except during the "off" period. No response could be observed in the remaining 12 cases. All cases with hyperkinesia showed an augmentation of this symptom during the use of the diet. The diet restriction was not found to be correlated with age, stage, duration of illness or duration of dopa treatment. The possible mechanism of the "off-on" phenomenon and some suggestions to influence it, are presented.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Wajsbort Jdoi
10.1007/BF00312550subject
Has Abstractpub_date
1977-04-28 00:00:00pages
59-66issue
1eissn
0340-5354issn
1432-1459journal_volume
215pub_type
杂志文章abstract::Nerve conduction studies (NCS) and electromyography (EMG), often shortened to 'EMGs', are a useful adjunct to clinical examination of the peripheral nervous system and striated skeletal muscle. NCS provide an efficient and rapid method of quantifying nerve conduction velocity (CV) and the amplitude of both sensory ner...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-012-6497-3
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 临床试验,杂志文章
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-015-7828-y
更新日期:2015-09-01 00:00:00
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1007/BF00887816
更新日期:1995-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s004150070054
更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314325
更新日期:1975-08-04 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314163
更新日期:1986-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313543
更新日期:1982-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00415-005-5006-3
更新日期:2005-11-01 00:00:00