Abstract：
:Urate is a natural antioxidant, and high serum urate levels could be protective against the development of amyotrophic lateral sclerosis (ALS). To determine if serum urate concentrations were lower in ALS patients than in healthy controls, we compared serum urate levels in 132 ALS patients and 337 age/sex-matched controls. Median urate levels were lower in ALS patients compared to controls (4.2mgl/dL [range:1.4-8.2], vs. 4.7 [1.7-13.1]; p = 0.04). In univariate analysis, high urate levels were less likely to be associated with ALS (odds ratio [OR]: 0.53; 95% CI: 0.29-0.97; p = 0.04), but after adjusting for age, sex and kidney function, the association was not statistically significant (OR: 0.63; 95% CI: 0.32-1.24; p = 0.18). Urate levels were lower in bulbar-onset ALS (3.9 mg/dL), compared to limb-onset ALS (4.3; p = 0.001), and in cases with longer disease duration compared to controls (4.1 mg/dL, vs. 4.7; p = 0.01). In this cross-sectional study, lower levels of serum urate were evident in ALS cases with bulbar-onset and longer disease duration, but were likely to be related to the malnutrition induced by ALS.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Zoccolella S,Simone IL,Capozzo R,Tortelli R,Leo A,D'Errico E,Logroscino Gdoi
10.1007/s00415-010-5735-9subject
Has Abstractpub_date
2011-02-01 00:00:00pages
238-43issue
2eissn
0340-5354issn
1432-1459journal_volume
258pub_type
杂志文章abstract：:Idiopathic hypereosinophilic syndrome (IHES) is a primary haematological condition characterised by persistent, otherwise unexplained hypereosinophilia sufficient to cause organ damage. Various neurological complications are reported, but very few have mentioned CNS pathology and none has included CNS vasculitis. Our ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7720-9
更新日期：2015-05-01 00:00:00
abstract：:Fifteen patients with Sneddon's syndrome presenting since 1979 were re-examined. After a neurological examination, an orienting test of mental ability as well as an electroencephalogram were performed in all patients. In 10 of the 15 patients computed tomography of the brain was performed, too. Preceding reports and t...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314215
更新日期：1989-01-01 00:00:00
abstract：:The history of our understanding of the pathogenesis and pathophysiology of multiple sclerosis are reviewed in the context of Charcot's contribution. The implications for treatment of the new knowledge gained from studies during life of pathology and pathogenesis (by MRI) and pathophysiology (by evoked potentials) are...
journal_title：Journal of neurology
pub_type： 传,历史文章,杂志文章
doi：10.1007/BF00838443
更新日期：1993-01-01 00:00:00
abstract：:Four cases of mild botulinus type B intoxication are reported with the clinical neurophysiological studies. Electromyographically tetanic stimulation of the N. ulnaris initially led to tetanic potentiation of the muscle action potential. After an interval without any symptoms tetanic reduction became apparent between ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00312957
更新日期：1978-02-14 00:00:00
abstract：:A comparative study of clinical and morphological findings in three fatal cases of acute necrotizing hemorrhagic encephalomyelitis (ANHE) and hyperacute experimental allergic encephalomyelitis (HEAE) in rhesus monkeys is reported. In all cases ANHE was characterized clinically by definite prodromal respiratory infecti...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313109
更新日期：1979-08-01 00:00:00
abstract：:Coenzyme Q10 (CoQ) was measured in serum and muscle of 17 patients with ophthalmoplegia plus (including 5 patients with Kearns-Sayre syndrome), in muscle of 9 patients with neurogenic atrophies, 5 patients with myositis, and 5 patients with progressive muscular dystrophies (including 1 patient with oculopharyngeal dys...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314404
更新日期：1989-02-01 00:00:00
abstract：:Two patients with chorea and polycythaemia vera are described. The literature on this rare association is reviewed and its pathophysiology discussed. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313895
更新日期：1985-01-01 00:00:00
abstract：:The diagnosis of Hallervorden-Spatz disease (HSD) has usually been made post mortem, although the recent description of characteristic abnormalities in the globus pallidus has suggested the possibility of an in vivo diagnosis. We present the clinical histories, neurological features and MRI findings of 11 patients, di...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00856805
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND:D-dimer levels are used in several clinical settings, such as in predicting venous thrombosis, cardioembolic stroke and cancer status. In the present study, we investigated the associations between plasma D-dimer levels at admission, clinical characteristics and mortality at discharge in cryptogenic stroke p...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8742-x
更新日期：2018-03-01 00:00:00
abstract：:This study aimed at identifying gender-specific differences in stroke knowledge, stroke risk perception and the educational effects of a multimodal educational intervention. We performed computer-assisted telephone surveys among an average sample of 500 members of the general public (44.0% male, 56.0% female), before ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5326-9
更新日期：2010-03-01 00:00:00
abstract：:The CHA(2)DS(2)-VASc score was developed to improve stroke risk stratification in atrial fibrillation (AF) patients. We sought to analyze the distribution and prognostic value of the CHA(2)DS(2)-VASc score in a cohort of ischemic stroke patients with AF. In total, 439 consecutive stroke patients with AF were studied. ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6259-7
更新日期：2012-04-01 00:00:00
abstract：:Corticospinal lesions cause impairments in voluntary motor control. Recent findings suggest that some degree of voluntary control may be taken over by a compensatory pathway involving the reticulospinal tract. In humans, evidence for this notion mainly comes from StartReact studies. StartReact is the acceleration of r...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-9027-0
更新日期：2018-11-01 00:00:00
abstract：:Auto-oxidation of levodopa generates toxic metabolites, such as free radicals, semiquinones and quinones. In vitro, levodopa is a powerful toxin that is lethal to cultures of neurones. This raises the concern that levodopa may also be toxic in vivo, and that chronic treatment with levodopa could induce further damage ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/pl00022914
更新日期：2000-04-01 00:00:00
abstract：:Nerve conduction studies (NCS) and electromyography (EMG), often shortened to 'EMGs', are a useful adjunct to clinical examination of the peripheral nervous system and striated skeletal muscle. NCS provide an efficient and rapid method of quantifying nerve conduction velocity (CV) and the amplitude of both sensory ner...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6497-3
更新日期：2012-07-01 00:00:00
abstract：:Peduncular hallucinosis (PH) is a syndrome of hallucinations and brainstem symptoms which has only been described in single case reports. A detailed analysis of five patients was undertaken to investigate the clincial characteristics, hallucinations and behavioural abnormalities of PH in greater detail. Frequent clini...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-0060-0254-4
更新日期：2006-12-01 00:00:00
abstract：:We report two adult Japanese sisters with L-2-hydroxy-glutaric aciduria (acidemia), both of whom were much older (aged 57, 47 years old) than previously reported patients (from neonate to 44 years old), and who presented with differing severity. Magnetic resonance imaging revealed typical subcortical white matter lesi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150050367
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:To quantify spinal cord atrophy and its impact on clinical disability in spinocerebellar ataxia (SCA) type 3 and 6. METHODS:Atrophy of the upper spinal cord was assessed by high resolution T1-weighted MRI of patients with SCA3 (n = 14) and SCA6 (n = 10). Furthermore, two groups of age- and sex-matched health...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0907-6
更新日期：2008-08-01 00:00:00
abstract：:KIF1A gene encodes the kinesin 1a protein, an axonal motor protein working in cargo transport along neurites. Variants in KIF1A were identified in different forms of neurodegenerative diseases with dominant and recessive inheritance. Homozygous recessive mutations were found in the hereditary sensory and autonomic neu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-015-7899-9
更新日期：2015-12-01 00:00:00
abstract：:Prolonged clinico-immunological observation of 85 patients with definite multiple sclerosis (MS) was performed in order to elucidate the connections between the clinical and immune state. A battery of immunological investigations was performed, including estimation of T-cell subpopulations in blood and cerebrospinal f...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00919713
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:The epidemiology of paraneoplastic neurological syndromes (PNS) remains to be defined. We present here the first population-based incidence study and report the clinical spectrum and antibody profile of PNS in a large area in Northeastern Italy. METHODS:We performed a 9-year (2009-2017) population-based epi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09544-1
更新日期：2020-01-01 00:00:00
abstract：:We wanted to determine the neurocognitive profile of adult patients with moyamoya disease prior to neurosurgical intervention. The experience of three United States medical centers, Columbia University, University of Illinois at Chicago, and the University of Texas Southwestern Medical Center at Dallas, were combined....
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-009-5424-8
更新日期：2010-05-01 00:00:00
abstract：:Cerebral hemodynamics play a pivotal role in stroke pathogenesis. Transcranial Doppler (TCD) studies demonstrated the importance of cerebral vasomotor reactivity (VMR) on the outcome of carotid artery occlusion (CAO). So far, positron emission tomography represents the best technique for detecting both hemodynamic and...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0244-6
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:Patients with classic ataxia-telangiectasia (A-T) generally die in the second or third decade of life. Clinical descriptions of A-T tend to focus on the symptoms at presentation. However, during the course of the disease, other symptoms and complications emerge. As long-term survivors with classic A-T develop...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09641-1
更新日期：2020-03-01 00:00:00
abstract：:Fatigue is an important contributor to quality of life in patients who survive aneurysmal subarachnoid hemorrhage (SAH), but the determinants of this fatigue are unclear. We assessed the occurrence of fatigue 1 year after SAH and its relation to physical or cognitive impairment, passive coping, and emotional problems,...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5891-y
更新日期：2011-06-01 00:00:00
abstract：:Although awareness of non-motor symptoms in Parkinson's disease (PD) has recently increased, little is known about their recognition and treatment in routine clinical practice. We therefore applied non-motor rating scales for dementia, depression, anxiety and excessive daytime sleepiness to a community-ascertained coh...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-5972-6
更新日期：2011-08-01 00:00:00
abstract：:Motor tests were performed in 50 HIV-infected patients in all stages according to the current CDC classification, but without any clinically evident central nervous system deficit, and the results compared with an age-matched control group. Patients were excluded from the study if there was alcohol or drug abuse, feve...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00315660
更新日期：1990-10-01 00:00:00
abstract：:We present a clinical, neuro-radiological and genetic study on a family with members suffering from an autosomal dominantly inherited syndrome characterised by epilepsy, cerebral calcifications and cysts, bone abnormalities; progressive neuro-cognitive deterioration and paranasal sinusitis. This syndrome shares severa...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7393-9
更新日期：2014-10-01 00:00:00
abstract：:Acute porphyrias are a group of inherited metabolic disorders representing overproduction syndromes with the formation of neurotoxic haem precursors. Clinical manifestations consist of acute attacks, which include abdominal pain, dysautonomia, mental symptoms, polyneuropathy and seizures mimicking many other acute neu...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0779-9
更新日期：2008-07-01 00:00:00
abstract：:A man, aged 63, had an illness which lasted 11 months from onset with pain under the left costal margin which radiated to the epigastrium, until his death from cardiac failure. His symptoms consisted principally of parasthesias and proximal weakness of both upper and lower extremities with atrophy of the shoulder and ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314720
更新日期：1978-04-14 00:00:00
abstract：:A patient is described who developed complex partial seizures with secondary generalization 3 years after a severe viral encephalitis with a CT and EEG identified lesion in the left insular cortex and its surrounding structures. When the seizures first occurred CT and MRI as well as repeated interictal conventional EE...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314461
更新日期：1989-07-01 00:00:00
