Abstract:
:A patient is described who developed complex partial seizures with secondary generalization 3 years after a severe viral encephalitis with a CT and EEG identified lesion in the left insular cortex and its surrounding structures. When the seizures first occurred CT and MRI as well as repeated interictal conventional EEG recordings were entirely normal. Single photon emission computed tomography (SPECT), however, revealed an area of increased 99mTc-hexamethyl propyleneamine oxime (HMPAO) uptake in the left insular cortex. After anticonvulsive therapy the seizures and the SPECT findings disappeared. 99mTc-HMPAO SPECT is a highly sensitive method for the demonstration of functional alterations in brain tissue. It can improve diagnosis of epilepsy and may provide additional information to monitor anticonvulsive therapy.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Dressler D,Voth E,Feldmann M,Henze T,Felgenhauer Kdoi
10.1007/BF00314461subject
Has Abstractpub_date
1989-07-01 00:00:00pages
300-2issue
5eissn
0340-5354issn
1432-1459journal_volume
236pub_type
杂志文章abstract::A woman affected by chronic progressive external ophthalmoplegia and muscle mitochondrial DNA deletion was studied by phosphorus magnetic resonance spectroscopy (31P-MRS) prior to and after 1 and 7 months of treatment with oral lipoic acid. Before treatment a decreased phosphocreatine (PCr) content was found in the oc...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00873552
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years. METHODS:Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-10004-4
更新日期:2020-11-01 00:00:00
abstract::Cognitive features, which begin before manifestation of the motor features, are an integral part of Huntington's disease and profoundly affect quality of life. A number of neuropsychological batteries have been used to assess this aspect of the condition, many of which are difficult to administer and time consuming, e...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7061-5
更新日期:2013-11-01 00:00:00
abstract::Although silent infarcts (SIs) are frequent in stroke patients, their clinical significance remains controversial, and their effect on stroke outcome remains unclear. This study evaluated the prevalence of SI on computed tomography, associated factors, and the effect on outcome in stroke patients. We studied 202 conse...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150170200
更新日期:2001-04-01 00:00:00
abstract::The computed tomography, magnetic resonance imaging and angiographic findings are described in a patient with Klippel-Trenaunay syndrome, who also had a cerebral haemorrhage from an arteriovenous malformation. The resulting aphasia disappeared completely after resorption of the haemorrhage. In this syndrome, the occur...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313992
更新日期:1986-02-01 00:00:00
abstract::Interferon beta (IFNbeta) therapy for multiple sclerosis (MS) is associated with a potential for the development of neutralising antibodies (NAbs) that negatively affect therapy. Several factors influence the development of NAbs, such as lack of complete sequence homology with the endogenous IFNbeta sequence, frequenc...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-006-0486-3
更新日期:2007-07-01 00:00:00
abstract::We have performed genetic screening on the skeletal muscle chloride channel gene (CLCN1) in Taiwanese population. A total of four patients with myotonia congenita (MC) together with 106 normal individuals were examined. All 23 exons of the CLCN1 gene were analysed by direct sequencing of PCR products to detect the nuc...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-004-0383-6
更新日期:2004-06-01 00:00:00
abstract::Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease with an estimated incidence of 1 in 8000 and is the most common form of muscular dystrophy affecting adults. An unstable, untranslated part of the myotonic dystrophy protein kinase gene on the long arm of chromosome 19, composed of CTG repeats, is ...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s004150050220
更新日期:1998-05-01 00:00:00
abstract::Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5403-0
更新日期:2010-05-01 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy with heterogeneous clinical presentation and genetic background. The axonal form (CMT2) is characterised by decreased action potentials indicating primary axonal damage. The underlying pathology involves axonal degeneration which is supposed to ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-015-7778-4
更新日期:2015-08-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involve...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5842-7
更新日期:2011-05-01 00:00:00
abstract::In this study of patients with spontaneous cervical artery dissections (sCAD) we searched for mutations in ABCC6, the candidate gene for Pseudoxanthoma elasticum (PXE). Genomic DNA samples from 12 sCAD patients with pronounced electron microscopic alterations in their dermal connective tissue and from 2 patients with ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-003-1139-4
更新日期:2003-08-01 00:00:00
abstract::Applying microarray technology to identify new diagnostic and prognostic markers in peripheral blood cells (PBC) after therapeutic intervention opens great perspectives regarding patient subclassification. Three recombinant products of the pleiotropic agent interferon beta (rIFN-beta) are available for disease modifyi...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-008-6010-1
更新日期:2008-12-01 00:00:00
abstract::An IgM antibody cytotoxic to normal human lymphocytes was found in 46.2% (male: 61.5%; female: 30.8%) of sera from chronic schizophrenics by means of a complement-dependent cytotoxicity test. The relationship between this antibody and the immunological manifestations of schizophrenia is discussed. ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00314296
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Most patients with multiple sclerosis presenting with a relapsing-remitting disease course at diagnosis transition to secondary progressive multiple sclerosis (SPMS) 1-2 decades after onset. SPMS is characterized by predominant neurodegeneration and atrophy. These pathogenic hallmarks result in unsa...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-020-09964-4
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND AND AIMS:The association between multiple sclerosis (MS) and depression has been well established but prevalence estimates have varied widely. The aims of this study were to assess the point prevalence of previously unrecognised symptoms of depression in a community-based population with MS and examine their...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-005-0963-0
更新日期:2006-02-01 00:00:00
abstract::Myasthenia gravis patients usually present with fluctuating, asymmetrical stress-dependent weakness in the absence of other neurological disturbances. In weak patients psychopathological disturbances are frequently reported and misdiagnosed as a psychiatric disorder. The question to what extent psychiatric symptoms ar...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-007-2022-5
更新日期:2007-05-01 00:00:00
abstract:INTRODUCTION:Patients with blepharospasm in addition to involuntary contraction of the orbicularis oculi muscle also have non-motor symptoms (psychiatric, sleep, cognitive, and ocular). In this paper, we investigated the relationship of non-motor with motor symptoms and the total burden of non-motor symptoms in patient...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09484-w
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Protein Z (PZ), a vitamin Kdependent protein, plays a role in inhibiting coagulation. Its plasma level or PZ gene polymorphisms have been discussed as risk factors for stroke with conflicting results reported between various studies. Only one of these polymorphisms was studied in a cohort of pati...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0958-8
更新日期:2008-10-01 00:00:00
abstract::In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-017-8553-5
更新日期:2017-09-01 00:00:00
abstract::The neurochemical abnormalities underlying vascular parkinsonism (VP) have not been well characterised. A better understanding may help to optimize pharmacological interventions. Since VP patients generally have a poorer response to l-Dopa than Parkinson's disease (PD) patients, we investigated whether levels of relev...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-013-7126-5
更新日期:2013-12-01 00:00:00
abstract::Clinical diagnosis of amyotrophic lateral sclerosis (ALS) in patients presenting with cramps and fasciculations may not be evident at the first consultation. Sequential reviews, clinical and neurophysiological, form an important part of clinical practice in such cases. Recent attempts to delineate a more benign group ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5791-1
更新日期:2011-04-01 00:00:00
abstract::The aim of our study was to compare the results obtained by intraoperative and postoperative subthalamic nucleus (STN) macrostimulation in Parkinson's disease (PD). One hundred three PD patients implanted with bilateral STN stimulation were included. The thresholds for efficacy and side effects (motor contraction; par...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5543-2
更新日期:2010-09-01 00:00:00
abstract::There has been a resurgence in the use of functional neurosurgery for Parkinson's disease. An important factor that has played a role in this development is the recent understanding of the functional anatomy of the basal ganglia including a knowledge of the changes in the activities of neurons in the internal segment ...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/BF03161079
更新日期:1999-09-01 00:00:00
abstract::Autonomic dysfunction is frequently observed in patients with multiple sclerosis (MS), but clinical studies disagree on the frequency and type of abnormalities in autonomic function tests. Orthostatic dizziness (OD) has been reported in up to 49% of patients, but the pathophysiological mechanisms are poorly understood...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s004150050407
更新日期:1999-07-01 00:00:00
abstract::A case is reported of severe agnosia for verbal and non-verbal sounds without associated aphasic disorder. A CT scan revealed bilateral, temporal lobe lesions from two ischaemic accidents that had occurred 9 months apart. The search for subtle deficits in the patient showed normal sensitivity to changes in the intensi...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313543
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:Mal de Debarquement Syndrome (MdDS) is the rare condition of enduring rocking sensations and subjective unsteadiness following a lengthy exposure to passive motion. The pathogenesis of MdDS is unknown and the available treatment is limited. Here, we developed an experimental model of MdDS that may facilita...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-019-09345-6
更新日期:2019-09-01 00:00:00
abstract::Multiple mononeuropathy (MM) occurs rarely during systemic lupus erythematosus (SLE) but may lead to major disability. The aim of this study was to investigate the clinic-pathological presentations of MM during SLE, as well as long-term outcomes. We conducted a multicentric retrospective study that included patients r...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-017-8519-7
更新日期:2017-06-01 00:00:00
abstract::Optic neuritis usually presents with rapid and gradual loss of vision that is either complete or incomplete, and typically associated with retro-orbital pain. To our knowledge there have been no documented reports of optic neuritis presenting with multiple episodes of amaurosis fugax, the sudden and transient loss of ...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5302-4
更新日期:2009-12-01 00:00:00
abstract::Acid maltase deficiency is described in non-identical adult twins. The onset of the disease can be traced into late infancy; the clinical picture is one of severe muscular dystrophy; respiratory insuficiency was the cause of death in one case. The autopsy showed the central nervous system, heart and liver to be spared...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313272
更新日期:1976-08-06 00:00:00