Abstract：
:Prognosis of patients with ischemic stroke requiring mechanical ventilation (MV) has been reported to be poor. However, longterm survival and functional outcome have scarcely been studied and nothing is known about the prevalence of cognitive impairment or depression in survivors and their quality of life (QoL). We identified all patients treated for acute ischemic stroke on a Neurological Intensive Care Unit during 3.5 years who required MV for more than 24 hours. Early mortality rate at 2 months and survival rates at 1 and 2 years were determined. Survivors were examined for functional outcome (modified Rankin Scale (mRS), Barthel Index), cognitive impairment (Mini Mental State Examination (MMSE)), depression (Beck Depression Inventory, BDI) and QoL (Short Form-36). Clinical characteristics on admission were analyzed for prognostic significance. Of 101 consecutive patients, 44% died within 60 days. Survival rates at 1 and 2 years were 40% and 33%, respectively. Age > 60 years (p = 0.002) and Glasgow Coma Scale score < 10 on admission (p = 0.002) were independent predictors of early and late mortality. History of myocardial infarction (p = 0.007) independently predicted late mortality at 2 years. Of 33 surviving patients, nine (27%) had a good functional outcome (mRS 0-2). Of 27 survivors who could be interviewed, 17 (63%) had no cognitive impairment (MMSE > 24) and 20 (74%) did not suffer from relevant depression (BDI < 19). In conclusion, longer-term survival of patients with ischemic stroke requiring MV was 33% and every fourth survivor resumed an independent life without dementia or depression. Older patients comatose on admission and with concomitant cardiovascular disease had the lowest probability of a favorable outcome.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Schielke E,Busch MA,Hildenhagen T,Holtkamp M,Küchler I,Harms L,Masuhr Fdoi
10.1007/s00415-005-0711-5keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
648-54issue
6eissn
0340-5354issn
1432-1459journal_volume
252pub_type
临床试验,杂志文章abstract：:The association of pathology and neurological deficit with quality of life (QoL) in multiple sclerosis (MS) is not fully understood. In this study, magnetic resonance imaging (MRI) measures of pathology--T1 and T2 lesion volume and ratio; active T2 lesion number; global and regional brain volume and atrophy; magnetiza...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6151-5
更新日期：2012-02-01 00:00:00
abstract：:The bulbocavernosus reflex (BCR) was examined in 39 normal potent men and in 252 patients with impaired potency of varying aetiology. For BCR evaluation minimum, maximum and mean latencies, the temporal dispersion in ten successive responses, together with minimum and maximum side differences from simultaneous recordi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314350
更新日期：1988-03-01 00:00:00
abstract：:Production of reactive oxygen species after cerebral blood flow disruption may enhance tissue damage through multiple molecular pathways. Changes in nitric oxide (NO) metabolism and oxidative stress status were investigated in 47 patients with ischemic stroke by measuring plasma nitric oxide (NO) and peroxynitrite (ON...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-0700-y
更新日期：2008-01-01 00:00:00
abstract：:Chronic exposure to manganese may induce parkinsonism similar to idiopathic Parkinson's disease (PD). However, clinical manifestations of manganism also have some features different from PD. The mechanisms of manganese-induced parkinsonism remain not fully understood. (99m)Tc-TRODAT-1 is a cocaine analogue that can bi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-0214-1
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVES:To evaluate daily life management and functional outcome of Idarucizumab administration in case of emergency situations in patients with Dabigatran treatment. DESIGN:Multicenter observational registry study. SETTING:All hospitals with full neurological departments (n = 6) in Munich, Germany INCLUDED PATIEN...
journal_title：Journal of neurology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00415-019-09492-w
更新日期：2019-11-01 00:00:00
abstract：:Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder of progressive heterotopic ossification (HO) caused by a recurrent activating mutation of ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. FOP is characterized by progressive HO, which is associated with inflammation in the setting o...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-012-6563-x
更新日期：2012-12-01 00:00:00
abstract：AIM:To investigate whether primary lateral sclerosis (PLS) represents part of the amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) spectrum of diseases. METHODS:Comprehensive assessment was taken on 21 patients with PLS and results were compared to patients diagnosed with pure motor ALS (n = 27) and ALS...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8917-5
更新日期：2018-08-01 00:00:00
abstract：:Whole genome screening is increasingly used to identify genetic risk factors for complex diseases. In this study, a genome wide linkage disequilibrium (LD) screen was performed in a cohort of Parkinson's disease (PD) patients from the UK (n = 195) using pooled DNA to facilitate efficient genotyping of 5546 microsatell...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-005-0686-2
更新日期：2005-05-01 00:00:00
abstract：:Inborn errors of metabolism in 40 children have been investigated by computed tomography to obtain data on the degree of cerebral involvement in neurodegenerative and storage disorders: 20 children had various mucopolysaccharidoses, 8 sphingolipidoses , 3 mucolipidoses, 2 oligosaccharidoses , 3 ceroidlipofuscinoses an...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313718
更新日期：1984-01-01 00:00:00
abstract：:Focal transcranial magnetic stimulation (TMS) of the motor cortex was used to study excitatory and inhibitory stimulation effects in 25 patients with writer's cramp and 25 healthy volunteers. We investigated excitatory and inhibitory corticospinally mediated motor effects in muscles contralateral to the stimulation si...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170269
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Stroke has a major impact on survivors. Our study was designed to describe the mental status and health-related quality of life (HRQoL) in long-term survivors of TIA or minor ischaemic stroke (MIS) and evaluate associations of mental and physical factors with HR-QoL. METHODS:A random sample of the 10-year s...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0480-9
更新日期：2007-08-01 00:00:00
abstract：:Multiple system atrophy and progressive supranuclear palsy are disabling neurodegenerative disorders, also known as atypical parkinsonian syndromes. Currently, no health economic evaluations of these diseases are available. The objective of this study was to evaluate disease-related costs in German patients with multi...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6028-7
更新日期：2011-10-01 00:00:00
abstract：:A total of 21 patients with normal-pressure hydrocephalus were examined. Cerebrospinal fluid (CSF) was collected before and after operation with a ventriculoperitoneal shunt. A slight plasma-like protein pattern indicating a blood-brain barrier (BBB) dysfunction was seen in 38% of the patients before operation. No cha...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313729
更新日期：1982-01-01 00:00:00
abstract：:Toxoplasma encephalitis, cryptococcal meningitis, progressive multifocal leukoencephalopathy (PML), and cytomegalovirus (CMV) encephalitis are the most common opportunistic infections of the central nervous system (CNS) in HIV-infected patients. They occur at variable degrees of immunosuppression, and their diagnosis ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s004150050341
更新日期：1999-04-01 00:00:00
abstract：:The clinicopathological findings of a 50-year-old man, who developed cervicothoracic syringomyelia at the age of 25 are presented. He was given radiation therapy at the age of 33. At the age of 57 he developed a foramen jugulare syndrome on the left, caused by a low grade leiomyosarcoma. Etiologically, the most attrac...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00313150
更新日期：1980-01-01 00:00:00
abstract：:The seasonal occurrence of relapses was analysed retrospectively in a group of 53 patients with treated dermatomyositis (DM) or polymyositis (PM). In DM, the incidence of both myositic and cutaneous relapses was highest in summer whereas in the PM group relapses was more evenly distributed throughout the seasons but l...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150200036
更新日期：2002-04-01 00:00:00
abstract：:Eye movements were studied in 13 patients with Friedreich's ataxia and correlated with MRI findings to investigate whether oculomotor abnormalities can be traced to cerebellar disturbances in this disease. One of the most prominent eye signs was fixation instability (square-wave jerks, SWJ.). Besides SWJ the patients ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00867423
更新日期：1995-08-01 00:00:00
abstract：:Despite ongoing improvements in the acute treatment of cerebrovascular diseases and organization of stroke services, many stroke survivors are in need of neurorehabilitation, as more than two-thirds show persisting neurologic deficits. While early elements of neurorehabilitation are already taking place on the stroke ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6247-y
更新日期：2012-05-01 00:00:00
abstract：:Psychiatric complaints are common in Parkinson's disease (PD), and have a significant influence in disease outcome and quality of life. Little attention has been paid to psychiatric symptoms at early stage disease. We aimed to screen a population of early stage PD patients for psychiatric symptoms and to study the rel...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-011-6140-8
更新日期：2012-01-01 00:00:00
abstract：:We present a clinical, neuro-radiological and genetic study on a family with members suffering from an autosomal dominantly inherited syndrome characterised by epilepsy, cerebral calcifications and cysts, bone abnormalities; progressive neuro-cognitive deterioration and paranasal sinusitis. This syndrome shares severa...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7393-9
更新日期：2014-10-01 00:00:00
abstract：:The effects of left- and right-sided hemispheric brain infarction on variability in circadian blood pressure and cardiovascular measures were investigated in 35 patients to test for asymmetry of the sympathetic consequences of stroke. No significant differences regarding age, size of infarction or extent and frequency...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00878874
更新日期：1995-05-01 00:00:00
abstract：:Gastrointestinal dysfunction, especially constipation, is one of the major problems in the daily life of patients with Parkinson's disease (PD). About 60 to 80% of PD patients suffer from constipation. Several studies have proven that constipation appears about 10 to 20 years prior to motor symptoms. More recently, Ab...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-1706-3
更新日期：2004-10-01 00:00:00
abstract：:The short-term benefits of levodopa/carbidopa intestinal gel (LCIG) in patients with advanced Parkinson's disease (PD) are well documented, but the long-term benefits are still uncertain. The aim of this study was to investigate the motor and cognitive outcome of LCIG treatment in advanced PD after a follow-up period ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-013-7235-1
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8901-0
更新日期：2018-07-01 00:00:00
abstract：INTRODUCTION:The present study aimed to survey the prevalence of prodromal symptoms of Parkinson's disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects. METHODS:We conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-r...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09714-6
更新日期：2020-05-01 00:00:00
abstract：:Fingolimod safety and efficacy data in relapsing-remitting multiple sclerosis (RRMS) are available up to 5 years, from an extension of a randomized, placebo-controlled, double-blind, phase 2 study, at a dose higher (5.0/1.25 mg) than the approved dose of 0.5 mg. The objective of the study is to present the end-of-stud...
journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-015-7834-0
更新日期：2015-12-01 00:00:00
abstract：:Left-handedness is most often genetic, but may also follow early, localised damage to the developing brain. This so-called "pathological" left-handedness syndrome is often associated with right hemisphere speech dominance. To find out whether verbal laterality or handedness were affected by congenital, intracranial ar...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-0941-3
更新日期：2003-01-01 00:00:00
abstract：:A 56-year-old woman with coeliac disease developed myoclonus of cortical origin and palatal myoclonus with lesions of subcortical white matter on magnetic resonance imaging. Myoclonus can thus be a prominent feature of coeliac disease encephalopathy. A slight vitamin E deficiency was found but does not satisfactorily ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314464
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:Cognitive impairment is a debilitating symptom experienced by ~ 50% of multiple sclerosis patients, with processing speed (PS) and memory most affected. Until now, the field has considered cognition in a binary fashion: patients are designated as impaired or not impaired. This designation is typically arrive...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8747-5
更新日期：2018-03-01 00:00:00
abstract：:We examined the peripheral nervous system (PNS) (nerve conduction velocity (NCV)) and the central nervous system (CNS) (basal ganglia-mediated psychomotor speed) in 93 males seropositive for human immunodeficiency virus type 1 (HIV-1) with no prior history of opportunistic brain disease, antiretroviral treatment or in...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-002-0707-3
更新日期：2002-06-01 00:00:00
