Abstract：
:Zebrafish (Danio rerio) is widely used as an animal model to understand the pathophysiology of cardiovascular diseases. Here, we present the adult cardiac phenotype of weak atrium, myh6-/-, which carry mutations in the zebrafish atrial myosin heavy chain. Homozygous mutants survive to adulthood and are fertile despite their initial weak atrial beat. In adult mutants, the atrium remains hypoplastic and shows elastin deposition while mutant ventricles exhibit increased size. In mammals, hypertrophy is the most common mechanism resulting in cardiomegaly. Using immunohistochemistry and confocal microscopy to measure cardiomyocyte cell size, density and proliferation, we show that the enlargement of the myh6-/- ventricle is predominantly due to hyperplasia. However, we identified similar transcriptional profiles to the mammalian hypertrophy response via RT-PCR of the hyperplastic ventricles. Furthermore, we show activation of the ER-stress pathway by western blot analysis. In conclusion, we can assume, based on our model, that molecular signaling pathways associated with hypertrophy in mammals, in combination with ER-stress activation, result in hyperplasia in zebrafish. In addition, to our knowledge, this is the first time to report elastin deposition in the atrium.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Sarantis P,Gaitanaki C,Beis Ddoi
10.1007/s00441-019-03044-4subject
Has Abstractpub_date
2019-11-01 00:00:00pages
279-288issue
2eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-019-03044-4journal_volume
378pub_type
杂志文章abstract：:The prolactin-producing cells are the first hormone-producing cells of the pars distalis to be differentiated within Ambystoma gracile. They first appear when the larvae attain a length of approximately 3.0 cm snout to vent length (SVL). Thyrotropes are observed as the next chromophilic cells to appear, and they occur...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223121
更新日期：1978-05-18 00:00:00
abstract：:Rat quiescin/sulphydryl oxidase (rQSOX) introduces disulphide bridges into peptides and proteins with the reduction of molecular oxygen to hydrogen peroxide. Its occurrence has been previously highlighted in a wide range of organs by reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analyses, ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-0043-x
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abstract：:The posterior rhombencephalic tela choroidea of the bullfrog was examined by electron microscopy. This membrane, the pia-ependymal roof of the caudal hindbrain, contains a large central region characterized by cuboidal ependymal cells which surround sizable microscopic apertures -- the interependymal pores. Ultrastruc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00220439
更新日期：1979-11-01 00:00:00
abstract：:Rat endometrial explants were cultured in a three-dimensional collagen/endothelial cell matrix to measure angiogenic activity, as represented by migration of vascular endothelial cells towards the explants. Minimal endothelial cell migratory activity was observed with endometrial explants taken during the four-day oes...
journal_title：Cell and tissue research
pub_type： 历史文章,杂志文章
doi：10.1007/BF00300706
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1921-x
更新日期：2014-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-017-2692-y
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217343
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221710
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1434-4
更新日期：2012-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00224731
更新日期：1989-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216473
更新日期：1987-06-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2418-6
更新日期：2016-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0655-z
更新日期：2008-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00235169
更新日期：1979-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00327275
更新日期：1991-03-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00236132
更新日期：1979-06-27 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215430
更新日期：1987-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00209138
更新日期：1978-06-08 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0456-9
更新日期：2007-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222058
更新日期：1977-07-26 00:00:00
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1996-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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abstract：:Alcohol and aldehyde dehydrogenases (ADHs and ALDHs) may be of interest in the pathology of Parkinson's disease (PD) because of their role in protection against toxins and in retinoid metabolism, which is required for growth and development of the mesencephalic dopamine system. In the present study, the spatial and te...
journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219936
更新日期：1975-12-18 00:00:00
