Prostaglandins and the developing kidney.

abstract：:Laboratory tests are critical in the detection and timely treatment of infection. Two categories of tests are commonly used in neonatal sepsis management: those that identify the pathogen and those that detect host response to a potential pathogen. Decision-making around antibiotic choice is related to the performance...

journal_title：Seminars in perinatology

authors： Rub DM,Dhudasia MB,Healy T,Mukhopadhyay S

更新日期：2020-12-01 00:00:00

abstract：:The developing heart undergoes a remarkable metabolic transformation as it adjusts to the higher-oxygen, extrauterine environment. During gestation, glycolysis and lactate oxidation constitute the major sources of adenosine triphosphate (ATP) for the fetal heart. After birth, however, there is a rapid shift from carbo...

journal_title：Seminars in perinatology

authors： Ascuitto RJ,Ross-Ascuitto NT

更新日期：1996-12-01 00:00:00

abstract：:Infants meeting retinopathy of prematurity (ROP) screening guidelines based on birth weight and gestational age undergo serial examinations by ophthalmologists for detection and treatment. However, less than 10% require treatment, and less than half develop ROP. Slow postnatal weight gain is highly predictive of ROP, ...

journal_title：Seminars in perinatology

authors： Lin L,Binenbaum G

更新日期：2019-10-01 00:00:00

abstract：:Preeclampsia, intrauterine growth restriction (IUGR), and placental abruption are obstetrical conditions that constitute the syndrome of ischemic placental disease or IPD, the leading cause of indicated preterm birth and an important cause of neonatal morbidity and mortality. While the phenotypic manifestations vary s...

journal_title：Seminars in perinatology

authors： Friedman AM,Cleary KL

更新日期：2014-04-01 00:00:00

abstract：:This article presents an overview of current topics related to the genetics of hearing loss. The review focuses on the approach toward a child with a sensorineural hearing loss of unknown etiology and the incorporation of genetic testing into the workup. Nongenetic causes of hearing loss are reviewed, as they are impo...

journal_title：Seminars in perinatology

authors： Rehm HL

更新日期：2005-06-01 00:00:00

abstract：:The future health of infants and children is dependent on the performance of clinical research in which infants participate. Achieving a proper balance between this social good and the obligation to protect infants who participate in research is a significant challenge. As investigators design and implement research p...

journal_title：Seminars in perinatology

authors： Diekema DS

更新日期：2009-12-01 00:00:00

abstract：:Asthma may be the most common potentialy serious medical problem to complicate pregnancy. Because severe uncontrolled asthma may cause both maternal and fetal morbidity and mortality, pharmacological asthma therapy is often necessary during pregnancy. Only 1 published randomized controlled clinical trial has evaluated...

journal_title：Seminars in perinatology

authors： Schatz M

更新日期：2001-06-01 00:00:00

abstract：:Newborn screening describes various tests that can occur during the first few hours or days of a newborn's life and have the potential for preventing severe health problems, including death. Newborn screening has evolved from a simple blood or urine screening test to a more comprehensive and complex screening system c...

journal_title：Seminars in perinatology

authors： Therrell BL,Padilla CD,Loeber JG,Kneisser I,Saadallah A,Borrajo GJ,Adams J

更新日期：2015-04-01 00:00:00

abstract：:Health care simulation is a powerful educational tool to help facilitate learning for clinicians and change their practice to improve patient outcomes and safety. To promote effective life-long learning through simulation, the educator needs to consider individuals, their experiences, and their environments. Effective...

journal_title：Seminars in perinatology

authors： Zigmont JJ,Kappus LJ,Sudikoff SN

更新日期：2011-04-01 00:00:00

abstract：:Neonatal herpes simplex virus (HSV) infection is one of the life-threatening infections of newborns. It affects approximately 1,500 to 2,200 infants per year in the United States. Changes in the presentation of neonatal HSV infection over the past two decades include an increase in the frequency of skin, eye, and mout...

journal_title：Seminars in perinatology

authors： Jacobs RF

更新日期：1998-02-01 00:00:00

abstract：:The unexpectedness of genital ambiguity in an infant creates an urgent and stressful situation. A logical approach, using a team of specialists together with nursery staff and physicians, allows each member to contribute expertise and unnecessary overlap of investigations. The psychological needs of the parents should...

journal_title：Seminars in perinatology

authors： McGillivray BC

更新日期：1992-12-01 00:00:00

abstract：:This article reviews the central role of nutrition in advancing the maternal, newborn, and child health agenda with a focus on evidence for effective interventions generated using randomized controlled trials in low- and middle-income countries (LMIC). The 1000 days spanning from conception to 2 years of life are a cr...

journal_title：Seminars in perinatology

authors： Christian P,Mullany LC,Hurley KM,Katz J,Black RE

更新日期：2015-08-01 00:00:00

abstract：:Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes. Pregnancy places predisposed wo...

journal_title：Seminars in perinatology

authors： Smok DA

更新日期：2014-08-01 00:00:00

abstract：:Extracorporeal membrane oxygenation (ECMO) is a highly technical and complex method of life support. Patient and circuit emergencies on ECMO are rare, but in these cases, prompt and correct actions to address the crisis are needed to prevent morbidity and mortality. ECMO simulation programs have gained popularity in r...

journal_title：Seminars in perinatology

authors： Johnston L,Oldenburg G

更新日期：2016-11-01 00:00:00

abstract：:Nutrition plays a critical role in the prevention and management of bronchopulmonary dysplasia (BPD). Growth failure in infants with BPD is predominantly due to malnutrition. Malnutrition can worsen BPD by compromising lung growth. Feeding difficulties in these infants can further affect nutrition. Dexamethasone, used...

journal_title：Seminars in perinatology

authors： Biniwale MA,Ehrenkranz RA

更新日期：2006-08-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are frequently used during pregnancy (premature labor, polyhydramnios) and the immediate postnatal period (closure of patent ductus arteriosus). This article evaluates the renal effect of 3 nonspecific COX inhibitors (aspirin, indomethacin, and ibuprofen) in newborn rabbits. Five g...

journal_title：Seminars in perinatology

authors： Guignard JP

更新日期：2002-12-01 00:00:00

abstract：:The Lancet Neonatal Survival Series categorized neonatal health interventions into 3 service delivery modes: "Outreach," "Family-Community Care," and "Facility-based Clinical Care." Family-Community Care services generally have a greater potential impact on neonatal health than Outreach services, with similar costs. C...

journal_title：Seminars in perinatology

authors： Schiffman J,Darmstadt GL,Agarwal S,Baqui AH

更新日期：2010-12-01 00:00:00

abstract：:The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants (birth weight 600 to 1,250 g)...

journal_title：Seminars in perinatology

authors： Vohr B,Allan WC,Scott DT,Katz KH,Schneider KC,Makuch RW,Ment LR

更新日期：1999-06-01 00:00:00

abstract：:A single course of antenatal corticosteroids is a rare example of a treatment that yields both a health benefit and a cost savings. This article reviews the history and background of antenatal corticosteroids, its use in clinical practice and the controversy today regarding the use of multiple courses of antenatal cor...

journal_title：Seminars in perinatology

authors： Murphy K,Aghajafari F,Hannah M

更新日期：2001-10-01 00:00:00

abstract：:The highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected every aspect of medical practice and has all but ceased clinical, translational and basic science research. Pregnant women appear to be similarly affected by the virus as non-pregnant adults. As obstetricians, not only do w...

journal_title：Seminars in perinatology

authors： Mourad M,Bousleiman S,Wapner R,Gyamfi-Bannerman C

更新日期：2020-11-01 00:00:00

abstract：:The words research and experimentation continue to have the power to evoke fear in potential subjects. But much of standard practice, particularly in critical care settings, involves interventions of unknown efficacy and safety. Innovation also abounds in practice settings, typically unchecked by prospective or retros...

journal_title：Seminars in perinatology

authors： Fost N

更新日期：1998-06-01 00:00:00

abstract：:This review evaluates and compares, by using the best available medical evidence, the risks and benefits of postnatal steroid use in very low birth weight infants. Systemic postnatal steroids are effective at reducing the risk of chronic lung disease in ventilated very low birth weight infants; they appear to be most ...

journal_title：Seminars in perinatology

authors： Kennedy KA

更新日期：2001-12-01 00:00:00

abstract：:Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. New genes may be inserted in mice, specific genes inactivated or "knocked out," and more complex animals created in which genes can be turned on or off at different times in development or in different tissues. These...

journal_title：Seminars in perinatology

authors： Glasser SW,Nogee LM

更新日期：2006-12-01 00:00:00

abstract：:The primary methods currently in use for imaging the infant brain are cranial ultrasound (CUS), computed tomography (CT) and magnetic resonance imaging (MRI). This review outlines the relative strengths and weaknesses of these modalities in relation to the premature infant, with specific focus on the correlations betw...

journal_title：Seminars in perinatology

authors： Neil JJ,Inder TE

更新日期：2004-12-01 00:00:00

abstract：:Inhaled nitric oxide (iNO), a selective pulmonary vasodilator, is available for treatment of persistent pulmonary hypertension of the newborn in term and near-term neonates. iNO decreases pulmonary vascular resistance leading to diminished extrapulmonary shunt and also has a microselective effect which improves ventil...

journal_title：Seminars in perinatology

authors： Kinsella JP,Abman SH

更新日期：2000-12-01 00:00:00

abstract：:Invasive candidiasis (IC) is a leading cause of morbidity and mortality in preterm infants. Even if successfully treated, IC can cause significant neurodevelopmental impairment. Preterm infants are at increased risk for hematogenous Candida meningoencephalitis owing to increased permeability of the blood-brain barrier...

journal_title：Seminars in perinatology

authors： Tripathi N,Watt K,Benjamin DK Jr

更新日期：2012-12-01 00:00:00

abstract：:Medium- and long-term outcomes have been collected and described among survivors of neonatal intensive care units for decades, for a number of purposes: (1) quality control within units, (2) comparisons of outcomes between NICUs, (3) clinical trials (whether an intervention improves outcomes), (4) end-of-life decision...

journal_title：Seminars in perinatology

authors： Janvier A,Farlow B,Baardsnes J,Pearce R,Barrington KJ

更新日期：2016-12-01 00:00:00

abstract：:Traditionally, genetic testing has been too slow or perceived to be impractical to initial management of the critically ill neonate. Technological advances have led to the ability to sequence and interpret the entire genome of a neonate in as little as 26 h. As the cost and speed of testing decreases, the utility of w...

journal_title：Seminars in perinatology

authors： Petrikin JE,Willig LK,Smith LD,Kingsmore SF

更新日期：2015-12-01 00:00:00

abstract：:There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine asse...

journal_title：Seminars in perinatology

authors： Patel N,Massolo AC,Kipfmueller F

更新日期：2020-02-01 00:00:00

abstract：:A large body of research indicates that children born very preterm are at increased risk for neurobehavioral impairments; however, research examining outcome for extremely preterm (EP) children is limited. This chapter will review the literature focusing on early development delay, general intellectual functioning, sp...

journal_title：Seminars in perinatology

authors： Anderson PJ,Doyle LW

更新日期：2008-02-01 00:00:00