Treatment and prophylaxis of invasive candidiasis.

Abstract:

:Invasive candidiasis (IC) is a leading cause of morbidity and mortality in preterm infants. Even if successfully treated, IC can cause significant neurodevelopmental impairment. Preterm infants are at increased risk for hematogenous Candida meningoencephalitis owing to increased permeability of the blood-brain barrier, so antifungal treatment should have adequate central nervous system penetration. Amphotericin B deoxycholate, lipid preparations of amphotericin B, fluconazole, and micafungin are first-line treatments of IC. Fluconazole prophylaxis reduces the incidence of IC in extremely premature infants, but its safety has not been established for this indication, and as yet, the product has not been shown to reduce mortality in neonates. Targeted prophylaxis may have a role in reducing the burden of disease in this vulnerable population.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Tripathi N,Watt K,Benjamin DK Jr

doi

10.1053/j.semperi.2012.06.003

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

416-23

issue

6

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(12)00071-7

journal_volume

36

pub_type

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