Inhaled nitric oxide: current and future uses in neonates.

abstract：:Until recent years, prenatal genetic tests have been almost exclusively developed and implemented by academic physicians and laboratories. In the last several years, industry has led the development of novel prenatal genetic tests, funded clinical trials and implemented these tests into clinical practice. That these e...

journal_title：Seminars in perinatology

authors： Swanson A,Goldberg JD

更新日期：2018-08-01 00:00:00

abstract：:The onset of preeclampsia at or near to term is associated with low maternal and neonatal morbidity and mortality. In contrast, those patients (1%) who suffer early onset preeclampsia engender significant maternal and perinatal morbidity and mortality. Therefore, because of the lack of proven prophylaxis for preeclamp...

journal_title：Seminars in perinatology

authors： Myatt L,Miodovnik M

更新日期：1999-02-01 00:00:00

abstract：:Adverse birth outcomes such as preterm birth, low-birth weight, and infant mortality continue to disproportionately affect black and poor infants in the United States. Improvements in healthcare quality and access have not eliminated these disparities. The objective of this review was to consider societal factors, inc...

journal_title：Seminars in perinatology

authors： Burris HH,Hacker MR

更新日期：2017-10-01 00:00:00

abstract：:Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contrib...

journal_title：Seminars in perinatology

authors： Guttentag S

更新日期：2008-10-01 00:00:00

abstract：:The future health of infants and children is dependent on the performance of clinical research in which infants participate. Achieving a proper balance between this social good and the obligation to protect infants who participate in research is a significant challenge. As investigators design and implement research p...

journal_title：Seminars in perinatology

authors： Diekema DS

更新日期：2009-12-01 00:00:00

abstract：:Asthma may be the most common potentialy serious medical problem to complicate pregnancy. Because severe uncontrolled asthma may cause both maternal and fetal morbidity and mortality, pharmacological asthma therapy is often necessary during pregnancy. Only 1 published randomized controlled clinical trial has evaluated...

journal_title：Seminars in perinatology

authors： Schatz M

更新日期：2001-06-01 00:00:00

abstract：:Pulmonary aspiration of gastric contents is a leading cause of maternal morbidity and mortality for patients during labor. The risk is increased in those women who require obstetric surgery and general anesthesia. Furthermore, gastric aspiration is believed to be largely preventable. Care providers can reduce the risk...

journal_title：Seminars in perinatology

authors： Rowe TF

更新日期：1997-08-01 00:00:00

abstract：:Accurate assessment of fetal growth status requires the definition of an optimal standard, which represents the growth potential of the baby. Against this standard, individually 'customized' percentiles can be calculated. They improve the distinction between normal and abnormal, and help in our understanding and diagn...

journal_title：Seminars in perinatology

authors： Gardosi J

更新日期：2004-02-01 00:00:00

abstract：:STDs can be one of the most common antepartum complications in high-risk gravidas. Screening for gonorrhea, syphilis, HPV, and possibly hepatitis B and chlamydial infection, should be considered in most, if not all, pregnant women. Familiarity with the common clinical presentations and treatment of bacterial STDs will...

journal_title：Seminars in perinatology

authors： Wendel GD Jr

更新日期：1990-04-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit. Here we review the epidemiology and pathophysiology of NEC, with an emphasis on the latest research findings and potential areas for future research. NEC continues to be one of the most deva...

journal_title：Seminars in perinatology

authors： Lin PW,Nasr TR,Stoll BJ

更新日期：2008-04-01 00:00:00

abstract：:For many years, all of the described cases of monoamine neurotransmitter deficiency were associated with hyperphenylalaninemia that was generally detected at neonatal screening. It is now clear that inherited deficiency of monoamines often occurs in the absence of hyperphenylalaninemia and that the normal battery of s...

journal_title：Seminars in perinatology

authors： Hyland K

更新日期：1999-04-01 00:00:00

abstract：:Use of immunosuppressants during pregnancy is indicated for anti-rejection therapy in transplantation patients and treatment of autoimmune diseases. Maternal side effects include nephrotoxocity and hepatotoxicity. All immunosuppressant drugs cross the placenta. Immunosuppressant use during the first trimester is not s...

journal_title：Seminars in perinatology

authors： Little BB

更新日期：1997-04-01 00:00:00

abstract：:Hormones are necessary for the growth of mammary glands, for initiation of the secretory process, and for the maintenance of an established lactation in all mammals. Hormonal changes which occur in late pregnancy and the early postpartum period are described and graphed. This data was derived from research with anim...

journal_title：Seminars in perinatology

authors： Tucker HA

更新日期：1979-07-01 00:00:00

abstract：:Peri-viable birth raises an array of complex moral and legal concerns. This article discusses the problem with defining viability, touches on its relationship to abortion jurisprudence, and analyzes a few interesting normative implications of current medical practice at the time of peri-viable birth. ...

journal_title：Seminars in perinatology

authors： Sayeed SA

更新日期：2014-02-01 00:00:00

abstract：:Preterm birth occurs in 7% to 12% of all deliveries, but accounts for over 85% of all perinatal morbidity and mortality. Although the ability of obstetric care providers to identify women at risk for preterm delivery has improved, the overall incidence of preterm birth has remained unchanged for the past 30 years. Pre...

journal_title：Seminars in perinatology

authors： Norwitz ER,Robinson JN

更新日期：2001-08-01 00:00:00

abstract：:Late preterm infants (34-37 weeks postmenstrual age at birth) are intermediate between less mature preterm infants and infants born at 38 weeks or more in regard to autonomic brain stem maturation. Ventilatory responses to CO(2) in preterm infants born at 33 to 36 week are significantly higher than in infants born at ...

journal_title：Seminars in perinatology

authors： Hunt CE

更新日期：2006-04-01 00:00:00

abstract：:Diagnostic errors remain understudied in neonatology. The limited available evidence, however, suggests that diagnostic errors in the neonatal intensive care unit (NICU) result in significant and long-term consequences. In this narrative review, we discuss how the concept of diagnostic errors framed as missed opportun...

journal_title：Seminars in perinatology

authors： Shafer G,Singh H,Suresh G

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Breastmilk is recommended as the exclusive source of nutrition for infants younger than 6 months due to the numerous health benefits for both infants and mothers. Although many women are prescribed medications during pregnancy and postpartum, limited data are available to assist women in weighing the benefits...

journal_title：Seminars in perinatology

authors： Sprague J,Wisner KL,Bogen DL

更新日期：2020-04-01 00:00:00

abstract：:Up to the immediate past, and perhaps even to the present, a major difference between care of the fetus and of the neonate was the ability to examine directly the physical and biochemical traits of the unborn patient. In a span of time as short as perhaps 10 years it has become progressively possible to institute almo...

journal_title：Seminars in perinatology

authors： Manning FA

更新日期：1989-08-01 00:00:00

abstract：:Newborn screening (NBS) reaches approximately all of the 4 million newborns in the United States each year and has been effective in significantly reducing the morbidity and mortality that results from certain congenital conditions. The comprehensive NBS system can be divided into preanalytic (education and screening)...

journal_title：Seminars in perinatology

authors： Therrell BL Jr,Schwartz M,Southard C,Williams D,Hannon WH,Mann MY,PEAS Organizing and Working Groups.

更新日期：2010-04-01 00:00:00

abstract：:Newborn screening describes various tests that can occur during the first few hours or days of a newborn's life and have the potential for preventing severe health problems, including death. Newborn screening has evolved from a simple blood or urine screening test to a more comprehensive and complex screening system c...

journal_title：Seminars in perinatology

authors： Therrell BL,Padilla CD,Loeber JG,Kneisser I,Saadallah A,Borrajo GJ,Adams J

更新日期：2015-04-01 00:00:00

abstract：:A large body of research indicates that children born very preterm are at increased risk for neurobehavioral impairments; however, research examining outcome for extremely preterm (EP) children is limited. This chapter will review the literature focusing on early development delay, general intellectual functioning, sp...

journal_title：Seminars in perinatology

authors： Anderson PJ,Doyle LW

更新日期：2008-02-01 00:00:00

abstract：:The ichthyoses encompass a variety of genetic disorders marked by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant associated morbidity and mortality, with the majority of complications arising as a result of impaired barrier function....

journal_title：Seminars in perinatology

authors： Craiglow BG

更新日期：2013-02-01 00:00:00

abstract：:There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine asse...

journal_title：Seminars in perinatology

authors： Patel N,Massolo AC,Kipfmueller F

更新日期：2020-02-01 00:00:00

abstract：:The American Heart Association (AHA) categorizes pulmonary embolism (PE) into three main categories based on the presence or absence of hemodynamic changes and evidence of right ventricular dysfunction. The AHA characterizes massive PE as occurring in the setting of persistent hypotension, profound bradycardia, or pul...

journal_title：Seminars in perinatology

authors： Handal-Orefice RC,Moroz LA

更新日期：2019-06-01 00:00:00

abstract：:Tumors are a rare but important cause of mortality and morbidity in the neonate. There is a wide spectrum of benign and malignant tumors that can occur, some of which have a unique presentation and behavior in this age group. It is important to recognize that tumors such as stage IVS neuroblastoma, which have a good p...

journal_title：Seminars in perinatology

authors： Weitzman S,Grant R

更新日期：1997-02-01 00:00:00

abstract：:The words research and experimentation continue to have the power to evoke fear in potential subjects. But much of standard practice, particularly in critical care settings, involves interventions of unknown efficacy and safety. Innovation also abounds in practice settings, typically unchecked by prospective or retros...

journal_title：Seminars in perinatology

authors： Fost N

更新日期：1998-06-01 00:00:00

abstract：:Health care simulation is a powerful educational tool to help facilitate learning for clinicians and change their practice to improve patient outcomes and safety. To promote effective life-long learning through simulation, the educator needs to consider individuals, their experiences, and their environments. Effective...

journal_title：Seminars in perinatology

authors： Zigmont JJ,Kappus LJ,Sudikoff SN

更新日期：2011-04-01 00:00:00

abstract：:This review documents and assesses recent trends in sudden infant death syndrome. We review medical literature, Internet resources, and national governmental data. A striking reduction in SIDS incidence of more than 50% has been observed in various countries after interventions, particularly during the early 1990s, to...

journal_title：Seminars in perinatology

authors： Ponsonby AL,Dwyer T,Cochrane J

更新日期：2002-08-01 00:00:00

abstract：:The intended and unintended effects of epidural labor analgesia are reviewed. Mothers randomized to epidural rather than parenteral opioid analgesia have better pain relief. Fetal oxygenation is not affected by analgesic method; however, neonates whose mothers received intravenous or intramuscular opioids rather than ...

journal_title：Seminars in perinatology

authors： Leighton BL,Halpern SH

更新日期：2002-04-01 00:00:00