Newborn Screening System Performance Evaluation Assessment Scheme (PEAS).

abstract：:Understanding the role of ion channels in the generation of slow waves and action potentials in the myometrium is critical in designing strategies to regulate uterine contractile activity. The development of the patch clamp technique has allowed the identification of specific types of channels in the myometrium and pr...

journal_title：Seminars in perinatology

authors： Sanborn BM

更新日期：1995-02-01 00:00:00

abstract：:Supplemental oxygen is often used as a life-saving therapy in the treatment of preterm infants. However, its protracted use can lead to the development of bronchopulmonary dysplasia (BPD), and more recently, has been associated with adversely affecting the general health of children and adolescents who were born prete...

journal_title：Seminars in perinatology

authors： Buczynski BW,Maduekwe ET,O'Reilly MA

更新日期：2013-04-01 00:00:00

abstract：:Neonatal hyperinsulinism (HI) is a clinical syndrome of pancreatic beta-cell dysfunction characterized by failure to suppress insulin secretion in the presence of hypoglycemia. Although rare, it is the most common cause for persistent hypoglycemia in the newborn period. Treatment can be extremely difficult, and partia...

journal_title：Seminars in perinatology

authors： Glaser B

更新日期：2000-04-01 00:00:00

abstract：:Here we provide a brief overview of the natural process of labor and its biochemical, hormonal, and mechanical characteristics that can be exploited in methods employed for induction of labor. ...

journal_title：Seminars in perinatology

authors： Irani RA,Foster S

更新日期：2015-10-01 00:00:00

abstract：:Use of immunosuppressants during pregnancy is indicated for anti-rejection therapy in transplantation patients and treatment of autoimmune diseases. Maternal side effects include nephrotoxocity and hepatotoxicity. All immunosuppressant drugs cross the placenta. Immunosuppressant use during the first trimester is not s...

journal_title：Seminars in perinatology

authors： Little BB

更新日期：1997-04-01 00:00:00

abstract：:Classical and subtypes of kernicterus associated with bilirubin toxicity can be differentiated in part with physiological auditory measures that include auditory-evoked potentials and measures of cochlear integrity. The combination of these auditory measures suggests that bilirubin exposure results in auditory system ...

journal_title：Seminars in perinatology

authors： Shapiro SM,Popelka GR

更新日期：2011-06-01 00:00:00

abstract：:We have hypothesized that an alteration in the production of endothelium-dependent factors by sex hormones is a potential unifying mechanism for both the decreased arterial contractility and the redistribution of cardiac output characteristic of normal pregnancy. Thus, the effect of pregnancy/ estradiol on any one vas...

journal_title：Seminars in perinatology

authors： Weiner CP,Thompson LP

更新日期：1997-10-01 00:00:00

abstract：:It is clear that external vibroacoustic stimulation with the EAL produces remarkable changes in FHR and fetal movement patterns that are related to changes in fetal behavior. The clinical significance of these studies has been addressed in small series on human fetuses by many authors. There is an obvious lack of unif...

journal_title：Seminars in perinatology

authors： Gagnon R

更新日期：1989-10-01 00:00:00

abstract：:Neonatal erythropoiesis is limited by a relatively inadequate production of erythropoietin. This is likely the result of dependence on the hepatic production of erythropoietin and an incomplete switchover to renal production. The present model of neonatal erythropoiesis suggests that the use of exogenous erythropoieti...

journal_title：Seminars in perinatology

authors： Doyle JJ

更新日期：1997-02-01 00:00:00

abstract：:Clinically silent upper genital tract microbial infections have been strongly associated with spontaneous preterm delivery, especially prior to 32 weeks gestational age. This condition represents a potentially preventable or reversible cause of preterm birth using safe, readily available, and inexpensive antibiotics. ...

journal_title：Seminars in perinatology

authors： Andrews WW,Goldenberg RL,National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

更新日期：2003-06-01 00:00:00

abstract：:Infants meeting retinopathy of prematurity (ROP) screening guidelines based on birth weight and gestational age undergo serial examinations by ophthalmologists for detection and treatment. However, less than 10% require treatment, and less than half develop ROP. Slow postnatal weight gain is highly predictive of ROP, ...

journal_title：Seminars in perinatology

authors： Lin L,Binenbaum G

更新日期：2019-10-01 00:00:00

abstract：:Adverse birth outcomes such as preterm birth, low-birth weight, and infant mortality continue to disproportionately affect black and poor infants in the United States. Improvements in healthcare quality and access have not eliminated these disparities. The objective of this review was to consider societal factors, inc...

journal_title：Seminars in perinatology

authors： Burris HH,Hacker MR

更新日期：2017-10-01 00:00:00

abstract：:Obesity is a major risk factor for many obstetrical complications, including pre-eclampsia, gestational diabetes, indicated preterm birth, macrosomia, and stillbirth. Clinicians should be aware of the unique obstetrical management considerations related to obesity, including recommendations for alterations in prenatal...

journal_title：Seminars in perinatology

authors： Thornburg LL

更新日期：2011-12-01 00:00:00

abstract：:For many years, all of the described cases of monoamine neurotransmitter deficiency were associated with hyperphenylalaninemia that was generally detected at neonatal screening. It is now clear that inherited deficiency of monoamines often occurs in the absence of hyperphenylalaninemia and that the normal battery of s...

journal_title：Seminars in perinatology

authors： Hyland K

更新日期：1999-04-01 00:00:00

abstract：:The use of broad spectrum antimicrobials, the emergence of multiresistant organisms, and the hospital drug costs associated with antimicrobials have all driven the need for institutions to develop strategies to control the use of antimicrobials. Formulary restrictions, prior approval mechanisms, treatment guidelines, ...

journal_title：Seminars in perinatology

authors： Kubin CJ

更新日期：2002-10-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit. Here we review the epidemiology and pathophysiology of NEC, with an emphasis on the latest research findings and potential areas for future research. NEC continues to be one of the most deva...

journal_title：Seminars in perinatology

authors： Lin PW,Nasr TR,Stoll BJ

更新日期：2008-04-01 00:00:00

abstract：:Surviving extremely low-birth-weight infants are at risk of severe neurodevelopmental disability. Transfusion with packed red cells is almost universal in the care of these infants, but the hemoglobin threshold at which these transfusions should be given is unclear. Different clinical trials of restrictive (low hemogl...

journal_title：Seminars in perinatology

authors： Whyte RK

更新日期：2012-08-01 00:00:00

abstract：:Preeclampsia, intrauterine growth restriction (IUGR), and placental abruption are obstetrical conditions that constitute the syndrome of ischemic placental disease or IPD, the leading cause of indicated preterm birth and an important cause of neonatal morbidity and mortality. While the phenotypic manifestations vary s...

journal_title：Seminars in perinatology

authors： Friedman AM,Cleary KL

更新日期：2014-04-01 00:00:00

abstract：:Retinopathy of Prematurity (ROP) is a preventable neovascular retinal disease with a lifetime impact on vision and ocular morbidities. Retinal vessel immaturity and oxygen therapy, influenced or modulated by several risk factors including oxidative stress, intermittent hypoxia and desaturations, inflammation, infectio...

journal_title：Seminars in perinatology

authors： Aranda JV,Qu J,Valencia GB,Beharry KD

更新日期：2019-10-01 00:00:00

abstract：:The primary methods currently in use for imaging the infant brain are cranial ultrasound (CUS), computed tomography (CT) and magnetic resonance imaging (MRI). This review outlines the relative strengths and weaknesses of these modalities in relation to the premature infant, with specific focus on the correlations betw...

journal_title：Seminars in perinatology

authors： Neil JJ,Inder TE

更新日期：2004-12-01 00:00:00

abstract：:The unexpectedness of genital ambiguity in an infant creates an urgent and stressful situation. A logical approach, using a team of specialists together with nursery staff and physicians, allows each member to contribute expertise and unnecessary overlap of investigations. The psychological needs of the parents should...

journal_title：Seminars in perinatology

authors： McGillivray BC

更新日期：1992-12-01 00:00:00

abstract：:The words research and experimentation continue to have the power to evoke fear in potential subjects. But much of standard practice, particularly in critical care settings, involves interventions of unknown efficacy and safety. Innovation also abounds in practice settings, typically unchecked by prospective or retros...

journal_title：Seminars in perinatology

authors： Fost N

更新日期：1998-06-01 00:00:00

abstract：:Acute renal failure in the newborn is a common problem and is typically classified as prerenal, intrinsic renal disease including vascular insults, and obstructive uropathy. In the newborn, renal failure may have a prenatal onset in congenital diseases such as renal dysplasia with or without obstructive uropathy and i...

journal_title：Seminars in perinatology

authors： Andreoli SP

更新日期：2004-04-01 00:00:00

abstract：:Minimally invasive surgery has been one of the most important surgical advances in the last 15 years. The development of smaller instruments has allowed pediatric surgeons to apply this rapidly evolving technology to neonates. Congenital neonatal deformities including tracheoesophageal fistula, patent ductus arteriosu...

journal_title：Seminars in perinatology

authors： Georgeson KE,Robertson DJ

更新日期：2004-06-01 00:00:00

abstract：:Nuchal translucency (NT) describes an echo-free area, below the skin, in the posterior nuchal and back region of the fetus and is typically observed in the first and early second trimester of pregnancy. A wide NT has been correlated with chromosomal and congenital abnormalities in the fetus. An accurate NT measurement...

journal_title：Seminars in perinatology

authors： Abuhamad A

更新日期：2005-12-01 00:00:00

abstract：:In mammals, a master circadian clock resides in the suprachiasmatic nuclei of the anterior hypothalamus. The suprachiasmatic nuclei is composed of multiple, single-cell circadian oscillators, which, when synchronized, lead to coordinated circadian outputs that ultimately regulate overt rhythms. Several "clock genes" h...

journal_title：Seminars in perinatology

authors： Reppert SM

更新日期：2000-08-01 00:00:00

abstract：:Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene t...

journal_title：Seminars in perinatology

authors： Memi F,Ntokou A,Papangeli I

更新日期：2018-12-01 00:00:00

abstract：:Until recent years, prenatal genetic tests have been almost exclusively developed and implemented by academic physicians and laboratories. In the last several years, industry has led the development of novel prenatal genetic tests, funded clinical trials and implemented these tests into clinical practice. That these e...

journal_title：Seminars in perinatology

authors： Swanson A,Goldberg JD

更新日期：2018-08-01 00:00:00

abstract：:Prostaglandins PGE2, PGD2, PGI2, and PGF2 alpha, as well as thromboxanes and leukotrienes, are synthesized by the fetal and neonatal kidney. The major prostaglandin, PGE2, PGD2, and PGI2, increase RBF, free water clearance, urine flow, and natriuresis. Alterations in the synthetic and catabolic activity of renal prost...

journal_title：Seminars in perinatology

authors： Gleason CA

更新日期：1987-01-01 00:00:00

abstract：:Accurate assessment of fetal growth status requires the definition of an optimal standard, which represents the growth potential of the baby. Against this standard, individually 'customized' percentiles can be calculated. They improve the distinction between normal and abnormal, and help in our understanding and diagn...

journal_title：Seminars in perinatology

authors： Gardosi J

更新日期：2004-02-01 00:00:00