Abstract:
:Classical and subtypes of kernicterus associated with bilirubin toxicity can be differentiated in part with physiological auditory measures that include auditory-evoked potentials and measures of cochlear integrity. The combination of these auditory measures suggests that bilirubin exposure results in auditory system damage initially at the level of the brainstem, progressing to the level of the VIII cranial nerve and then to greater neural centers. There is no evidence of neural damage at the level of the cochlea. Auditory neural damage from bilirubin toxicity ranges from neural timing deficits, including neural firing delays and dyssynchrony, to neural response reduction and even elimination of auditory neural responses. This condition is comprehensively described as auditory neuropathy spectrum disorder. Independent measures of cochlear function and auditory neural function up to the level of the brainstem can effectively diagnose auditory neural damage resulting from bilirubin neurotoxicity. Intervention, including cochlear implants can be effective.
journal_name
Semin Perinatoljournal_title
Seminars in perinatologyauthors
Shapiro SM,Popelka GRdoi
10.1053/j.semperi.2011.02.011subject
Has Abstractpub_date
2011-06-01 00:00:00pages
162-70issue
3eissn
0146-0005issn
1558-075Xpii
S0146-0005(11)00040-1journal_volume
35pub_type
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