What we have learned from an antibiotic trial in fetal fibronectin positive women.

Abstract:

:Clinically silent upper genital tract microbial infections have been strongly associated with spontaneous preterm delivery, especially prior to 32 weeks gestational age. This condition represents a potentially preventable or reversible cause of preterm birth using safe, readily available, and inexpensive antibiotics. Fetal fibronectin detected in cervical and vaginal secretions between 22 to 24 weeks' gestation is a powerful predictor of subsequent risk for spontaneous preterm delivery. Evidence indicates that the detection of fetal fibronectin in cervical/vaginal secretions could represent a marker for clinically silent upper genital tract microbial infection. Thus, the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (NICHD MFMU) Network performed a randomized clinical trial to determine if antibiotic treatment (metronidazole plus erythromycin) of asymptomatic women with a positive cervical or vaginal fetal fibronectin test in early pregnancy will reduce the risk of spontaneous preterm delivery. No significant difference was observed between the antibiotic- and placebo-treated groups for spontaneous preterm delivery before 37 week's gestation (relative risk 1.17, 95% confidence interval 0.80-1.70). Therefore, use of the fetal fibronectin test to identify women for antibiotic treatment in an effort to prevent preterm birth should be discouraged, and current clinical use of the fetal fibronectin test should be limited to its negative predictive value.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Andrews WW,Goldenberg RL,National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

doi

10.1016/s0146-0005(03)00006-5

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

231-8

issue

3

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(03)00006-5

journal_volume

27

pub_type

杂志文章,评审
  • Induction of labor in women with a prior cesarean delivery.

    abstract::Given the historically high rates of cesarean delivery in the United States, obstetrical providers must often consider an induction of labor for women with a history of prior cesarean delivery versus repeat cesarean delivery. Clinical evaluation of this scenario involves weighing the benefits of a successful trial of ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.07.011

    authors: Hoffman MK,Hunter Grant G

    更新日期:2015-10-01 00:00:00

  • Morbidly adherent placenta.

    abstract::Morbidly adherent placenta, which describes placenta accreta, increta, and percreta, implies an abnormal implantation of the placenta into the uterine wall. The incidence of placenta accreta has increased significantly over the past several decades, with the main risk factors include prior cesarean section and placent...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2013.06.014

    authors: Abuhamad A

    更新日期:2013-10-01 00:00:00

  • Prevention of the first cesarean delivery: the role of operative vaginal delivery.

    abstract::While the cesarean delivery (CD) rates have increased worldwide, operative vaginal delivery (OVD) rates continue to decline, with the United States having some of the lower rates amongst developed countries. It is clear that the use of forceps or vacuum can safely assist in accomplishing a vaginal delivery and prevent...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.04.021

    authors: Gei AF

    更新日期:2012-10-01 00:00:00

  • Inpatient obstetric management of COVID-19.

    abstract:OBJECTIVE:To describe inpatient management strategies and considerations for pregnant patients with severe acute respiratory syndrome coronavirus 2 infection. FINDINGS:The novel coronavirus has posed challenges to both obstetric patients and the staff caring for them, due to its variable presentation and current limit...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1016/j.semperi.2020.151280

    authors: Aubey J,Zork N,Sheen JJ

    更新日期:2020-11-01 00:00:00

  • Abruptio placentae and disseminated intravascular coagulopathy.

    abstract::Abruptio placentae is an important cause of vaginal bleeding in the latter half of pregnancy. The key factor in the pathophysiology is hemorrhage at the decidual-placental interface. Small episodes may escape clinical detection, but severe grades impact significantly on fetal and maternal morbidity and mortality, with...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2009.02.005

    authors: Hall DR

    更新日期:2009-06-01 00:00:00

  • Neuroblastoma in the neonate.

    abstract::Neuroblastoma is the most common malignant neoplasm occurring in the neonate and arguably the most variable in its presentation. This review examines differences in the tumor's clinical course in the context of known biologic determinants of behavior. Tumors that would go undetected except for prenatal ultrasonography...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(99)80035-4

    authors: Lukens JN

    更新日期:1999-08-01 00:00:00

  • Amniotic fluid abnormalities.

    abstract::The complex nature of amniotic fluid reflects contributions from many fetal systems, many functional roles, and multiple interactions with fetal maturation, obstetric, and maternal factors. Simple ultrasound measurement, probably done best with the maximum vertical pocket method, has a clinical role in fetal surveilla...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2008.04.012

    authors: Harman CR

    更新日期:2008-08-01 00:00:00

  • Nitric oxide and pregnancy.

    abstract::We have hypothesized that an alteration in the production of endothelium-dependent factors by sex hormones is a potential unifying mechanism for both the decreased arterial contractility and the redistribution of cardiac output characteristic of normal pregnancy. Thus, the effect of pregnancy/ estradiol on any one vas...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(97)80003-1

    authors: Weiner CP,Thompson LP

    更新日期:1997-10-01 00:00:00

  • The mid-trimester genetic sonogram.

    abstract::The genetic sonogram is a composite algorithm combining multiple individual markers to increase Down syndrome risk prediction. Transformation of sonographic information into a standard mathematical format represented an early challenge that has now been surmounted. Using increasingly sophisticated mathematical techniq...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2005.06.005

    authors: Bahado-Singh RO,Oz UA,Mendilcioglu I,Mahoney MJ

    更新日期:2005-08-01 00:00:00

  • Examination of the twin placenta.

    abstract::Twin birth rates have increased dramatically over the past three decades, and twins currently account for 3% of all pregnancies. Twin pregnancies of any type are at risk for prematurity. In addition, monochorionic twin pregnancies (25-30% of all twin pregnancies) are predisposed to a specific set of complications, inc...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2014.10.005

    authors: Paepe ME

    更新日期:2015-02-01 00:00:00

  • Amniotic fluid volume and its relationship to fetal fluid balance: review of experimental data.

    abstract::The studies described above collectively suggest that, whenever there is a decrease in fluid balance in the fetus, both fetal urine flow and tracheal secretion into the amniotic space are decreased. Conversely, when fetal hydration is increased, both urine and tracheal flows into the amniotic fluid may be increased. T...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Brace RA

    更新日期:1986-04-01 00:00:00

  • Community-informed models of perinatal and reproductive health services provision: A justice-centered paradigm toward equity among Black birthing communities.

    abstract::Perinatal health outcomes in the United States continue to worsen, with the greatest burden of inequity falling on Black birthing communities. Despite transdisciplinary literature citing structural racism as a root cause of inequity, interventions continue to be mostly physician-centered models of perinatal and reprod...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semperi.2020.151267

    authors: Julian Z,Robles D,Whetstone S,Perritt JB,Jackson AV,Hardeman RR,Scott KA

    更新日期:2020-08-01 00:00:00

  • Treatment and prophylaxis of invasive candidiasis.

    abstract::Invasive candidiasis (IC) is a leading cause of morbidity and mortality in preterm infants. Even if successfully treated, IC can cause significant neurodevelopmental impairment. Preterm infants are at increased risk for hematogenous Candida meningoencephalitis owing to increased permeability of the blood-brain barrier...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.06.003

    authors: Tripathi N,Watt K,Benjamin DK Jr

    更新日期:2012-12-01 00:00:00

  • Imaging perinatal brain injury in premature infants.

    abstract::The primary methods currently in use for imaging the infant brain are cranial ultrasound (CUS), computed tomography (CT) and magnetic resonance imaging (MRI). This review outlines the relative strengths and weaknesses of these modalities in relation to the premature infant, with specific focus on the correlations betw...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2004.10.004

    authors: Neil JJ,Inder TE

    更新日期:2004-12-01 00:00:00

  • Acute renal failure in the newborn.

    abstract::Acute renal failure in the newborn is a common problem and is typically classified as prerenal, intrinsic renal disease including vascular insults, and obstructive uropathy. In the newborn, renal failure may have a prenatal onset in congenital diseases such as renal dysplasia with or without obstructive uropathy and i...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2003.11.003

    authors: Andreoli SP

    更新日期:2004-04-01 00:00:00

  • Timing of indicated late preterm and early-term birth in chronic medical complications: diabetes.

    abstract::The number of pregnant women who have type 2 diabetes and the number found to have gestational diabetes are progressively increasing. In the future, as many as 20% of pregnant women may be diagnosed with diabetes. Although there is consensus regarding many issues in the treatment of pregnant women with diabetes, there...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.05.003

    authors: Catalano PM,Sacks DA

    更新日期:2011-10-01 00:00:00

  • New techniques in evaluation of the cervix.

    abstract::The process of parturition is poorly understood, but the cervix clearly plays a key role. Because of this, recent research efforts have been directed at objective quantification of cervical remodeling. Investigation has focused on two basic areas: (1) quantification of tissue deformability and (2) presence, orientatio...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2017.08.006

    authors: Feltovich H,Carlson L

    更新日期:2017-12-01 00:00:00

  • Prostaglandin and leukotriene receptors in pulmonary, vascular, and uterine smooth muscle.

    abstract::Prostaglandins are currently used to maintain patency of the ductus arteriosus and to elicit uterine contractions. Prostaglandin synthesis inhibitors are used to promote closure of the ductus and their administration in pregnant animals has produced fetal pulmonary hypertension. Exposure of the human fetus to inhibito...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Wendelberger KJ

    更新日期:1987-01-01 00:00:00

  • Got daddy issues? Fathers impact on perinatal outcomes.

    abstract::Mothers' genetics as well as their environment, behaviors, and social determinants of health are all important factors influencing short and long term childhood outcomes. There is an emerging body of literature investigating the extent to which fathers also contribute to their offspring's future health. We review fath...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1016/j.semperi.2020.151238

    authors: Brumberg HL,Shah SI

    更新日期:2020-06-01 00:00:00

  • Neurodevelopmental outcome of extremely low-birth-weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.

    abstract::Surviving extremely low-birth-weight infants are at risk of severe neurodevelopmental disability. Transfusion with packed red cells is almost universal in the care of these infants, but the hemoglobin threshold at which these transfusions should be given is unclear. Different clinical trials of restrictive (low hemogl...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.04.010

    authors: Whyte RK

    更新日期:2012-08-01 00:00:00

  • Obstetrical venous thromboembolism: Epidemiology and strategies for prophylaxis.

    abstract::Venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality. While pregnancy alone is a risk factor for VTE, additional population-based risk factors such as obesity are becoming increasingly common, particularly in the developed world. Maternal death from VTE is amenable to prevention a...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.11.011

    authors: Friedman AM,Ananth CV

    更新日期:2016-03-01 00:00:00

  • Modulators of inflammation in Bronchopulmonary Dysplasia.

    abstract::Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30-50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung tha...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2018.09.009

    authors: Savani RC

    更新日期:2018-11-01 00:00:00

  • Cirrhosis and portal hypertension in pregnancy.

    abstract::Cirrhosis and portal hypertension infrequently coincide with pregnancy but increase maternal and fetal morbidity and mortality when present. Chronic liver disease and portal hypertension are not contraindications to pregnancy but necessitate intensive monitoring throughout pregnancy. The complications of liver disease...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(98)80048-7

    authors: Russell MA,Craigo SD

    更新日期:1998-04-01 00:00:00

  • Making cesarean delivery SAFE in low- and middle-income countries.

    abstract::Cesarean birth (CB) rates are rising, globally. The global burden of CB is having a mixed effect on pregnancy outcomes and requires significant clinical and economic resources. The context of CB care in low- and middle-income countries is further complicated by barriers to facility-based care itself, followed by issue...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2019.03.015

    authors: Harrison MS,Goldenberg RL

    更新日期:2019-08-01 00:00:00

  • Antifungal pharmacotherapy for neonatal candidiasis.

    abstract::Candida is a leading cause of late onset infection (> 3 days of age) in the premature infant. Therefore, decisions about the diagnosis and management of infections caused by Candida are commonplace in the neonatal intensive care unit. Despite this fact, there are few comparative trials about treatment of neonatal Cand...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(03)00060-0

    authors: Bliss JM,Wellington M,Gigliotti F

    更新日期:2003-10-01 00:00:00

  • Sleep-disordered breathing and future cardiovascular disease risk.

    abstract::Sleep-disordered breathing occurs in 0.6-15% of reproductive age women. This condition is associated with an increased lifetime risk of cardiovascular disease, cardiovascular mortality, and all-cause mortality. A substantial body of evidence demonstrated increased perinatal morbidity among pregnancies affected by SDB ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.05.010

    authors: Cain MA,Ricciuti J,Louis JM

    更新日期:2015-06-01 00:00:00

  • Management of early pregnancy loss, with a focus on patient centered care.

    abstract::Early pregnancy loss is the most common complication in pregnancy. Management options for miscarriage include expectant management, medical intervention, or surgical aspiration. Non-surgical and surgical management are all safe and acceptable options for medically uncomplicated patients. Patient and provider preferenc...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2018.12.005

    authors: Shorter JM,Atrio JM,Schreiber CA

    更新日期:2019-03-01 00:00:00

  • Antenatal corticosteroids for preterm birth.

    abstract::A single course of antenatal corticosteroids is a rare example of a treatment that yields both a health benefit and a cost savings. This article reviews the history and background of antenatal corticosteroids, its use in clinical practice and the controversy today regarding the use of multiple courses of antenatal cor...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2001.26418

    authors: Murphy K,Aghajafari F,Hannah M

    更新日期:2001-10-01 00:00:00

  • Cesarean section on request at 39 weeks: impact on shoulder dystocia, fetal trauma, neonatal encephalopathy, and intrauterine fetal demise.

    abstract:PURPOSE:The purpose of this analysis was to determine the impact on specific forms of neonatal morbidity and mortality by allowing women to opt for delivery by elective cesarean section at 39 weeks of gestation (EGA). According to the National Vital Statistics Reports, over 70% of deliveries in the U.S. annually are at...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2006.07.009

    authors: Hankins GD,Clark SM,Munn MB

    更新日期:2006-10-01 00:00:00

  • School performance in adolescents with and without periventricular-intraventricular hemorrhage in the neonatal period.

    abstract::Long-term sequelae of preterm birth have been studied extensively up until the age of 5 to 8 years. However, the cognitive development of adolescents born preterm has received limited attention. The objective of this study is to determine school performance in adolescents born very preterm. We have followed up a cohor...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2004.08.007

    authors: van de Bor M,den Ouden L

    更新日期:2004-08-01 00:00:00