Modulators of inflammation in Bronchopulmonary Dysplasia.

Abstract:

:Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30-50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung that results in an inflammatory response and ends in aberrant lung development with dysregulated angiogenesis and alveolarization. Significant morbidity and mortality are associated with this most common chronic lung disease of childhood. Thus, any therapies that decrease the incidence or severity of this condition would have significant impact on morbidity, mortality, human costs, and healthcare expenditure. It is clear that an inflammatory response and the elaboration of growth factors and cytokines are associated with the development of BPD. Numerous approaches to control the inflammatory process leading to the development of BPD have been attempted. This review will examine the anti-inflammatory approaches that are established or hold promise for the prevention or treatment of BPD.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Savani RC

doi

10.1053/j.semperi.2018.09.009

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

459-470

issue

7

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(18)30087-9

journal_volume

42

pub_type

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