Abstract：
:Up to the immediate past, and perhaps even to the present, a major difference between care of the fetus and of the neonate was the ability to examine directly the physical and biochemical traits of the unborn patient. In a span of time as short as perhaps 10 years it has become progressively possible to institute almost all neonatal investigative maneuvers to the fetus. In the last 5 years, the concept of treating the decreased fetus in utero has developed from a multitude of sources. The psychological, physical, and therapeutic barriers between the fetus and newborn are sharply eroded now, and may soon disappear. The impact on the advances discussed is likely to be very significant, since the near elimination of all late gestation (greater than 20 weeks) perinatal death is not unrealistic, and a major thrust in either preventing or ameliorating disease of genetic origin is at least worthy of serious contemplation. With each advance, either concrete or speculative, comes a need to reassign training priorities, professional self-definition, societal resources, and societal priorities. The distinct possibility of achieving near excellence in perinatal care exists. The possibility that society and its physicians would wish to ensure that such events are entirely desirable despite the cost is less certain. It is likely that the definitive confrontation will occur on this field.
journal_name
Semin Perinatoljournal_title
Seminars in perinatologyauthors
Manning FAsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
342-51issue
4eissn
0146-0005issn
1558-075Xjournal_volume
13pub_type
杂志文章abstract：:The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants (birth weight 600 to 1,250 g)...
journal_title：Seminars in perinatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0146-0005(99)80065-2
更新日期：1999-06-01 00:00:00
abstract：:Acute renal failure in the newborn is a common problem and is typically classified as prerenal, intrinsic renal disease including vascular insults, and obstructive uropathy. In the newborn, renal failure may have a prenatal onset in congenital diseases such as renal dysplasia with or without obstructive uropathy and i...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2003.11.003
更新日期：2004-04-01 00:00:00
abstract：:Gene therapy carries the potential to treat more than 10,000 human monogenic diseases and benefit an even greater number of complex polygenic conditions. The repurposing of CRISPR/Cas9, an ancient bacterial immune defense system, into a gene-editing technology has armed researchers with a revolutionary tool for gene t...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2018.09.003
更新日期：2018-12-01 00:00:00
abstract：:The product label required by the FDA for every drug approved for marketing in the US is a legal document that originates with the company that wants to market the drug, but it must be approved by the FDA. Despite the recognized limitations of registries, the FDA's new labeling rule, effective from July 1, 2015, has g...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2015.08.004
更新日期：2015-11-01 00:00:00
abstract：:Asthma may be the most common potentialy serious medical problem to complicate pregnancy. Because severe uncontrolled asthma may cause both maternal and fetal morbidity and mortality, pharmacological asthma therapy is often necessary during pregnancy. Only 1 published randomized controlled clinical trial has evaluated...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2001.24569
更新日期：2001-06-01 00:00:00
abstract：:This review documents and assesses recent trends in sudden infant death syndrome. We review medical literature, Internet resources, and national governmental data. A striking reduction in SIDS incidence of more than 50% has been observed in various countries after interventions, particularly during the early 1990s, to...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2002.34774
更新日期：2002-08-01 00:00:00
abstract：:Accurate assessment of fetal growth status requires the definition of an optimal standard, which represents the growth potential of the baby. Against this standard, individually 'customized' percentiles can be calculated. They improve the distinction between normal and abnormal, and help in our understanding and diagn...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2003.12.002
更新日期：2004-02-01 00:00:00
abstract：:Neonatal hyperbilirubinemia is a normal postnatal phenomenon resulting from a transitional imbalance between the production and elimination of bilirubin in the neonate. Bilirubin has been shown to be not only a potent antioxidant, but also toxic at excessive concentrations. As a result, the biology of bilirubin, its p...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2001.23197
更新日期：2001-04-01 00:00:00
abstract：:Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30-50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung tha...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2018.09.009
更新日期：2018-11-01 00:00:00
abstract：:The medical literature demonstrates that inadequate hospital protocols or the lack of consistent protocols for diagnosis, management, consultation, and/or referral can lead to confusion and unnecessary variation in patient care. Incongruities in clinical settings have been repeatedly shown to compromise quality of pat...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2015.11.019
更新日期：2016-03-01 00:00:00
abstract：:This article reviews the literature on infectious diseases as a cause of stillbirth. Identifying a specific infection as a cause of stillbirth is limited by many obstacles. Nevertheless, "good faith" efforts estimate that approximately 9% to 15% of stillbirths are caused by infections. Infection may be especially impo...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2002.29839
更新日期：2002-02-01 00:00:00
abstract：:Hormones are necessary for the growth of mammary glands, for initiation of the secretory process, and for the maintenance of an established lactation in all mammals. Hormonal changes which occur in late pregnancy and the early postpartum period are described and graphed. This data was derived from research with anim...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1979-07-01 00:00:00
abstract：:Obesity is a major risk factor for many obstetrical complications, including pre-eclampsia, gestational diabetes, indicated preterm birth, macrosomia, and stillbirth. Clinicians should be aware of the unique obstetrical management considerations related to obesity, including recommendations for alterations in prenatal...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2011.05.015
更新日期：2011-12-01 00:00:00
abstract：:For nearly 30 years the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network has been conducting randomized trials in pregnant women, many of which have changed clinical practice. Since 1986, the MFMU Network has conducted 29 randomized tr...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2016.03.011
更新日期：2016-08-01 00:00:00
abstract：:Candida is a leading cause of late onset infection (> 3 days of age) in the premature infant. Therefore, decisions about the diagnosis and management of infections caused by Candida are commonplace in the neonatal intensive care unit. Despite this fact, there are few comparative trials about treatment of neonatal Cand...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0146-0005(03)00060-0
更新日期：2003-10-01 00:00:00
abstract：:Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes. Pregnancy places predisposed wo...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2014.04.019
更新日期：2014-08-01 00:00:00
abstract：:Doppler ultrasonography was introduced into clinical obstetric practice over 20 years ago. It is also accepted that a variety of common obstetrical complications such as preeclampsia and intrauterine growth restriction have their origin in abnormal development of the placental vasculature and this could be reflected i...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2001.22892
更新日期：2001-02-01 00:00:00
abstract：:The rapid evolution of the COVID-19 pandemic in New York City during the spring of 2020 challenged the Department of Obstetrics and Gynecology at Columbia University Irving Medical Center to rely on its core values to respond effectively. In particular, five core values, "5 C's," were engaged: Communication; Collabora...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1016/j.semperi.2020.151291
更新日期：2020-10-01 00:00:00
abstract：:Prostaglandins are currently used to maintain patency of the ductus arteriosus and to elicit uterine contractions. Prostaglandin synthesis inhibitors are used to promote closure of the ductus and their administration in pregnant animals has produced fetal pulmonary hypertension. Exposure of the human fetus to inhibito...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:Ultrasound has permeated the practice of anesthesiology and is becoming an essential tool for the obstetric anesthesiologist in the labor and delivery suite. The most common applications include guidance for neuraxial (epidural and spinal) anesthesia and acute pain nerve blocks, as well as guidance for central and per...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2014.07.006
更新日期：2014-10-01 00:00:00
abstract：:Laboratory tests are critical in the detection and timely treatment of infection. Two categories of tests are commonly used in neonatal sepsis management: those that identify the pathogen and those that detect host response to a potential pathogen. Decision-making around antibiotic choice is related to the performance...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1016/j.semperi.2020.151328
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:To describe inpatient management strategies and considerations for pregnant patients with severe acute respiratory syndrome coronavirus 2 infection. FINDINGS:The novel coronavirus has posed challenges to both obstetric patients and the staff caring for them, due to its variable presentation and current limit...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1016/j.semperi.2020.151280
更新日期：2020-11-01 00:00:00
abstract：:Traditional birth attendants (TBAs) provided delivery care throughout the world prior to the development of organized systems of medical care. In 2016, an estimated 22% of pregnant women delivered with a TBA, mostly in rural or remote areas that lacked formal health services. Still active in many regions of LMICs, the...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.03.013
更新日期：2019-08-01 00:00:00
abstract：:Inhaled nitric oxide (iNO), a selective pulmonary vasodilator, is available for treatment of persistent pulmonary hypertension of the newborn in term and near-term neonates. iNO decreases pulmonary vascular resistance leading to diminished extrapulmonary shunt and also has a microselective effect which improves ventil...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2000.20085
更新日期：2000-12-01 00:00:00
abstract：:Given the historically high rates of cesarean delivery in the United States, obstetrical providers must often consider an induction of labor for women with a history of prior cesarean delivery versus repeat cesarean delivery. Clinical evaluation of this scenario involves weighing the benefits of a successful trial of ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2015.07.011
更新日期：2015-10-01 00:00:00
abstract：:Transplant recipients are becoming pregnant with increasing frequency, and successful pregnancy outcomes have now been reported for women with all types of solid organ transplants. To prevent rejection of the transplanted organ, these patients are maintained on a life-long immunosuppressive regimen that must also be c...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2007.09.006
更新日期：2007-12-01 00:00:00
abstract：:Pharmacotherapy, or medication-assisted treatment (MAT), is a critical component of a comprehensive treatment plan for the pregnant woman with opioid use disorder (OUD). Methadone and buprenorphine are two types of opioid-agonist therapy which prevent withdrawal symptoms and control opioid cravings. Methadone is a lon...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：:In initiating enteral feedings for high-risk infants, clinicians struggle with three fundamental questions: When should enteral feedings be initiated? Should a period of trophic (minimal) feeding be provided? When feedings are advanced, how rapidly should the volume be increased? We present the findings of our systema...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2007.02.008
更新日期：2007-04-01 00:00:00
abstract：:Nutrition plays a critical role in the prevention and management of bronchopulmonary dysplasia (BPD). Growth failure in infants with BPD is predominantly due to malnutrition. Malnutrition can worsen BPD by compromising lung growth. Feeding difficulties in these infants can further affect nutrition. Dexamethasone, used...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2006.05.007
更新日期：2006-08-01 00:00:00
abstract：:The rapid rise of novel coronavirus disease 2019 (COVID-19) cases led the American Society for Reproductive Medicine (ASRM) to recommend immediate cessation of all new fertility treatment cycles on March 17, 2020. Controversial from the start, providers and patients expressed their opposition through online petitions,...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1016/j.semperi.2020.151288
更新日期：2020-11-01 00:00:00
