Early-onset intraventricular hemorrhage in preterm neonates: incidence of neurodevelopmental handicap.

Abstract:

:The neurodevelopmental outcome of very low birth weight infants experiencing early-onset intraventricular hemorrhage (IVH) occurring within the first 6 postnatal hours was compared with that of their peers without early-onset IVH at 3 years corrected age. The 440 surviving preterm infants (birth weight 600 to 1,250 g) who had been enrolled in a multicenter, prospectively randomized, controlled trial evaluating the efficacy of postnatal indomethacin to prevent IVH were evaluated with the Stanford-Binet Intelligence Scale and neurological examinations at 3 years corrected age. All study infants had echoencephalography between 5 and 11 hours of life, and testing is reported for all children residing in English monolingual households at 3 years corrected age (i.e., from the obstetric due date). Fifty five of the 73 (75%) infants with IVH within the first 5 to 11 hours survived to 3 years of age, compared with 385 of the 432 (89%) children without early-onset hemorrhage who were alive at 3 years corrected age (P<.001). Eleven of the 29 (38%) English monolingual children with early-onset IVH had Stanford-Binet intelligence quotient scores of less than 70, compared with 47 of the 249 (19%) children without early IVH (P = .03). Similarly, 7 of 28 (25%) early IVH children were found to have cerebral palsy, compared with 20 of 241 (8%) children without early IVH (P = .01). These data suggest that infants who experience the early onset of IVH are at high risk for both cognitive and motor handicaps at 3 years corrected age.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Vohr B,Allan WC,Scott DT,Katz KH,Schneider KC,Makuch RW,Ment LR

doi

10.1016/s0146-0005(99)80065-2

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

212-7

issue

3

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(99)80065-2

journal_volume

23

pub_type

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