The origins of stillbirth: infectious diseases.

Abstract:

:This article reviews the literature on infectious diseases as a cause of stillbirth. Identifying a specific infection as a cause of stillbirth is limited by many obstacles. Nevertheless, "good faith" efforts estimate that approximately 9% to 15% of stillbirths are caused by infections. Infection may be especially important as a cause of stillbirth occurring early in pregnancy. Recognized causes include syphilis, toxoplasmosis, parvovirus B-19, chorioamnionitis, and Listeria monocytogenes. Other organisms that are "purported to cause" stillbirth include the genital mycoplasmas, Chlamydia trachomatis, HIV, group B streptococci, and others. No single strategy has been developed for effective prevention of stillbirth caused by infection. Six potential strategies and their rationale are presented, but the low rate of stillbirth in most situations would require large intervention trials for hypothesis testing. Infection is an important cause of stillbirth. Within the framework if determining epidemiological etiology, research should be initiated in the role of infectious causes.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Gibbs RS

doi

10.1053/sper.2002.29839

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

75-8

issue

1

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(02)80019-2

journal_volume

26

pub_type

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