Abstract:
:Laboratory tests are critical in the detection and timely treatment of infection. Two categories of tests are commonly used in neonatal sepsis management: those that identify the pathogen and those that detect host response to a potential pathogen. Decision-making around antibiotic choice is related to the performance of tests that directly identify pathogens. Advances in these tests hold the key to progress in antibiotic stewardship. Tests measuring host response, on the other hand, are an indirect marker of potential infection. While an important measure of the patient's clinical state, in the absence of pathogen detection these tests cannot confirm the appropriateness of antibiotic selection. The overall impact these tests then have on antibiotic utilization depends the test's specificity for bacterial infection, clinical scenario where it is being used and the decision-rule it is being integrated into for use. In this review we discuss common and emerging laboratory tests available for assisting management of neonatal infection and specifically focus on the role they play in optimizing antibiotic utilization.
journal_name
Semin Perinatoljournal_title
Seminars in perinatologyauthors
Rub DM,Dhudasia MB,Healy T,Mukhopadhyay Sdoi
10.1016/j.semperi.2020.151328subject
Has Abstractpub_date
2020-12-01 00:00:00pages
151328issue
8eissn
0146-0005issn
1558-075Xpii
S0146-0005(20)30111-7journal_volume
44pub_type
杂志文章abstract::The future health of infants and children is dependent on the performance of clinical research in which infants participate. Achieving a proper balance between this social good and the obligation to protect infants who participate in research is a significant challenge. As investigators design and implement research p...
journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
doi:10.1053/j.semperi.2014.10.005
更新日期:2015-02-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
pub_type: 杂志文章
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
doi:10.1016/s0146-0005(97)80003-1
更新日期:1997-10-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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更新日期:1998-08-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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更新日期:2015-04-01 00:00:00
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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