Prediction of preeclampsia.

Abstract:

:The onset of preeclampsia at or near to term is associated with low maternal and neonatal morbidity and mortality. In contrast, those patients (1%) who suffer early onset preeclampsia engender significant maternal and perinatal morbidity and mortality. Therefore, because of the lack of proven prophylaxis for preeclampsia, prediction of risk or identification of subclinical disease is desirable to identify patients for more intensive observation. There are certain at-risk groups of patients such as those with chronic hypertension, pregestational diabetes, multifetal gestation, and previous preeclampsia. These patients account for the majority of cases of preeclampsia in multiparas, yet only account for 14% of preeclampsia in nulliparous women. Thus, the majority of cases of preeclampsia arises from nulliparous women without medical complications at low risk. Differences in the time of onset, severity, and organ system involvement suggest there may be different underlying etiologies that ultimately lead to preeclampsia manifested as the triad of maternal hypertension, proteinuria, and edema. Distinct markers therefore may identify subgroups of at-risk patients with separate underlying causes. These markers ultimately could be used for diagnosis of disease before the clinical appearance of maternal disease (hypertension, proteinuria, and edema). Based on data from patients with established disease, with the involvement of various organ systems, potential candidate markers would include renal function (kallikrein-creatinine); coagulation and fibrinolytic systems and platelet activation (platelet volume); markers of vascular function (fibronectin, prostacyclin, thromboxane) and oxidant stress (lipid peroxides, 8-isoprostane, antioxidants, anticardiolipin antibodies, hemoglobin, iron, transferrin, homocysteine, hypertriglyceridemia, albumin isoforms); placental peptide hormones (CRH, CRHbp, activin, inhibin, hCG); vascular resistance (uteroplacental flow velocity waveforms); genetic markers; insulin resistance; and glucose intolerance. Although cross-sectional studies have identified these potential markers, they need to be evaluated in prospective longitudinal studies with rigorous definition of outcome to determine if they are useful in predicting preeclampsia and whether they can identify different subgroups of patients.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Myatt L,Miodovnik M

doi

10.1016/s0146-0005(99)80059-7

keywords:

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

45-57

issue

1

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(99)80059-7

journal_volume

23

pub_type

杂志文章,评审
  • Combined serum and ultrasound screening for detection of fetal aneuploidy.

    abstract::Experience gathered over the last decade from high-risk centers provide strong evidence that mid-trimester sonographic markers are sensitive for Down syndrome prediction. More recent data indicate that combining mid trimester sonography with traditional serum markers significantly improves diagnostic accuracy over eit...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2003.50013

    authors: Bahado-Singh R,Cheng CC,Matta P,Small M,Mahoney MJ

    更新日期:2003-04-01 00:00:00

  • Improving publication rates in a collaborative clinical trials research network.

    abstract::Unpublished results can bias biomedical literature, favoring positive over negative findings, primary over secondary analyses, and can lead to duplicate studies that unnecessarily endanger subjects and waste resources. The Neonatal Research Network's (NRN) publication policies for approving, reviewing, and tracking ab...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2016.05.003

    authors: Archer SW,Carlo WA,Truog WE,Stevenson DK,Van Meurs KP,Sánchez PJ,Das A,Devaskar U,Nelin LD,Petrie Huitema CM,Crawford MM,Higgins RD,Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research

    更新日期:2016-10-01 00:00:00

  • Genetically engineered mice in understanding the basis of neonatal lung disease.

    abstract::Advances in genetic engineering have allowed the creation of animals with additional or deleted genes. New genes may be inserted in mice, specific genes inactivated or "knocked out," and more complex animals created in which genes can be turned on or off at different times in development or in different tissues. These...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2006.09.001

    authors: Glasser SW,Nogee LM

    更新日期:2006-12-01 00:00:00

  • Role of microbiological tests and biomarkers in antibiotic stewardship.

    abstract::Laboratory tests are critical in the detection and timely treatment of infection. Two categories of tests are commonly used in neonatal sepsis management: those that identify the pathogen and those that detect host response to a potential pathogen. Decision-making around antibiotic choice is related to the performance...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1016/j.semperi.2020.151328

    authors: Rub DM,Dhudasia MB,Healy T,Mukhopadhyay S

    更新日期:2020-12-01 00:00:00

  • Prevention of preterm birth based on a short cervix: cerclage.

    abstract::In an attempt to prevent preterm birth, clinicians have recommended cerclage for women with shortened cervical length and other worrisome sonographic cervical features in the mid-trimester, although randomized trials have not supported this practice. Emerging data suggest that preterm birth is a complex and poorly und...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2009.06.005

    authors: Mancuso MS,Owen J

    更新日期:2009-10-01 00:00:00

  • The medical and legal aspects of maternal mortality.

    abstract::Sudden unexpected changes in the life of a family create many different emotions in various family members. The death of a young woman during or after her pregnancy is especially difficult because of the strain it places on family dynamics. One of the consequences is that there is, commonly, a newborn, and perhaps oth...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2011.09.014

    authors: Elliott JP

    更新日期:2012-02-01 00:00:00

  • Prediction and prevention of spontaneous preterm birth in twin gestations.

    abstract::The incidence of twin gestation has increased significantly over the past 30 years. One of the most significant public health implications of this trend is the increased incidence of preterm birth (PTB). Efforts to improve neonatal outcomes must address the rate of PTB, particularly among multiple gestations, which co...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2012.02.003

    authors: Brubaker SG,Gyamfi C

    更新日期:2012-06-01 00:00:00

  • Antepartum care in multiple gestation.

    abstract::Multiple gestation carries a significant risk of perinatal complications and mortality. Often twin neonates are delivered small and early with a perinatal mortality rate five to seven times that of singleton neonates. Increased morbidity and mortality is due to an increased incidence of antepartum complications, monoz...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:

    authors: Newton ER

    更新日期:1986-01-01 00:00:00

  • Lung maturation in diabetes in pregnancy: if and when to test.

    abstract::Poorly controlled maternal diabetes in pregnancy may delay fetal pulmonary maturation. However, diabetic women with good glycemic control have fetal lung maturation at the same gestational age as nondiabetic women. With modern ultrasound technology, gestational dates can be accurately assessed in the first or early se...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2002.33969

    authors: Piper JM

    更新日期:2002-06-01 00:00:00

  • Posttranslational regulation of surfactant protein B expression.

    abstract::Although a minor constituent by weight, surfactant protein B (SP-B) plays a major role in surfactant function. It is the unique structure of SP-B that promotes permeabilization, cross-linking, mixing, and fusion of phospholipids, facilitating the proper structure and function of pulmonary surfactant as well as contrib...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2008.08.003

    authors: Guttentag S

    更新日期:2008-10-01 00:00:00

  • The mid-trimester genetic sonogram.

    abstract::The genetic sonogram is a composite algorithm combining multiple individual markers to increase Down syndrome risk prediction. Transformation of sonographic information into a standard mathematical format represented an early challenge that has now been surmounted. Using increasingly sophisticated mathematical techniq...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2005.06.005

    authors: Bahado-Singh RO,Oz UA,Mendilcioglu I,Mahoney MJ

    更新日期:2005-08-01 00:00:00

  • What we have learned from an antibiotic trial in fetal fibronectin positive women.

    abstract::Clinically silent upper genital tract microbial infections have been strongly associated with spontaneous preterm delivery, especially prior to 32 weeks gestational age. This condition represents a potentially preventable or reversible cause of preterm birth using safe, readily available, and inexpensive antibiotics. ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(03)00006-5

    authors: Andrews WW,Goldenberg RL,National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network.

    更新日期:2003-06-01 00:00:00

  • The role of erythropoietin in the anemia of prematurity.

    abstract::Neonatal erythropoiesis is limited by a relatively inadequate production of erythropoietin. This is likely the result of dependence on the hepatic production of erythropoietin and an incomplete switchover to renal production. The present model of neonatal erythropoiesis suggests that the use of exogenous erythropoieti...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(97)80016-x

    authors: Doyle JJ

    更新日期:1997-02-01 00:00:00

  • Pharmacotherapy for depression and bipolar disorder during lactation: A framework to aid decision making.

    abstract:OBJECTIVE:Breastmilk is recommended as the exclusive source of nutrition for infants younger than 6 months due to the numerous health benefits for both infants and mothers. Although many women are prescribed medications during pregnancy and postpartum, limited data are available to assist women in weighing the benefits...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semperi.2020.151224

    authors: Sprague J,Wisner KL,Bogen DL

    更新日期:2020-04-01 00:00:00

  • Community-based intervention packages for improving perinatal health in developing countries: a review of the evidence.

    abstract::The Lancet Neonatal Survival Series categorized neonatal health interventions into 3 service delivery modes: "Outreach," "Family-Community Care," and "Facility-based Clinical Care." Family-Community Care services generally have a greater potential impact on neonatal health than Outreach services, with similar costs. C...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2010.09.008

    authors: Schiffman J,Darmstadt GL,Agarwal S,Baqui AH

    更新日期:2010-12-01 00:00:00

  • Theoretical foundations of learning through simulation.

    abstract::Health care simulation is a powerful educational tool to help facilitate learning for clinicians and change their practice to improve patient outcomes and safety. To promote effective life-long learning through simulation, the educator needs to consider individuals, their experiences, and their environments. Effective...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2011.01.002

    authors: Zigmont JJ,Kappus LJ,Sudikoff SN

    更新日期:2011-04-01 00:00:00

  • Other factors/conditions associated with cerebral palsy.

    abstract::The cause for most cases of cerebral palsy is unknown. There are however, risk factors that have been associated with this chronic neuromuscular disease. The objective of this article is to review the maternal and fetal conditions (other than asphyxia and infection) strongly associated with increased rate of cerebral ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/sper.2000.7052

    authors: Ramin SM,Gilstrap LC 3rd

    更新日期:2000-06-01 00:00:00

  • Environmental factors implicated in the causation of adverse pregnancy outcome.

    abstract::Adverse pregnancy outcome from environmental factors may include congenital anomalies, increased risk for miscarriage, preterm delivery, intrauterine growth restriction, and still birth. Apart from adverse pregnancy outcome, there may be effects on the other reproductive functions, like menstrual disorders and inferti...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2007.07.013

    authors: Triche EW,Hossain N

    更新日期:2007-08-01 00:00:00

  • The safe motherhood initiative: The development and implementation of standardized obstetric care bundles in New York.

    abstract::The medical literature demonstrates that inadequate hospital protocols or the lack of consistent protocols for diagnosis, management, consultation, and/or referral can lead to confusion and unnecessary variation in patient care. Incongruities in clinical settings have been repeatedly shown to compromise quality of pat...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.11.019

    authors: Burgansky A,Montalto D,Siddiqui NA

    更新日期:2016-03-01 00:00:00

  • Cytomegalovirus infection.

    abstract::Cytomegalovirus (CMV) infection is the most common perinatal infection and may result in severe injury to the fetus. Forty percent to 50% of infants delivered to mothers with primary CMV will have congenital infections. Of these, 5% to 18% will be overtly symptomatic at birth. The mortality rate in these children is a...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(98)80014-1

    authors: Brown HL,Abernathy MP

    更新日期:1998-08-01 00:00:00

  • Obstetrical venous thromboembolism: Epidemiology and strategies for prophylaxis.

    abstract::Venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality. While pregnancy alone is a risk factor for VTE, additional population-based risk factors such as obesity are becoming increasingly common, particularly in the developed world. Maternal death from VTE is amenable to prevention a...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2015.11.011

    authors: Friedman AM,Ananth CV

    更新日期:2016-03-01 00:00:00

  • Cardiovascular responses to aerobic exercise during pregnancy and postpartum.

    abstract::The many physiological and hormonal changes occurring during pregnancy have the potential to affect a woman's cardiovascular responses to aerobic exercise. For example, it seems that increased mass and dilation of the left ventricle allow maintenance of wall stress, ensuring adequate pumping function throughout gestat...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(96)80017-6

    authors: Pivarnik JM

    更新日期:1996-08-01 00:00:00

  • Toward an ethically responsible approach to vaginal birth after cesarean.

    abstract::Determining approach to delivery after a previous cesarean is among the most contentious areas of obstetrics. We present a framework for ethically responsible guidelines and practice regarding vaginal birth after cesarean. We describe ethical complexities of 3 key issues that mark the debate: the cesarean delivery rat...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2010.05.007

    authors: Lyerly AD,Little MO

    更新日期:2010-10-01 00:00:00

  • Modulators of inflammation in Bronchopulmonary Dysplasia.

    abstract::Over 50 years after its first description, Bronchopulmonary Dysplasia (BPD) remains a devastating pulmonary complication in preterm infants with respiratory failure and develops in 30-50% of infants less than 1000-gram birth weight. It is thought to involve ventilator- and oxygen-induced damage to an immature lung tha...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2018.09.009

    authors: Savani RC

    更新日期:2018-11-01 00:00:00

  • Maternal mortality in the United States--why is it important and what are we doing about it?

    abstract::Following dramatic reductions between the early 1900s and the early 1980s, the maternal mortality ratio began to rise, reaching a peak of almost 17 maternal deaths per 100,000 live births. Although this number pales in comparison with that found in sub-Saharan Africa and India, the troubling rise in the United States ...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章

    doi:10.1053/j.semperi.2011.09.004

    authors: King JC

    更新日期:2012-02-01 00:00:00

  • Neuroblastoma in the neonate.

    abstract::Neuroblastoma is the most common malignant neoplasm occurring in the neonate and arguably the most variable in its presentation. This review examines differences in the tumor's clinical course in the context of known biologic determinants of behavior. Tumors that would go undetected except for prenatal ultrasonography...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(99)80035-4

    authors: Lukens JN

    更新日期:1999-08-01 00:00:00

  • Morbidly adherent placenta.

    abstract::Morbidly adherent placenta, which describes placenta accreta, increta, and percreta, implies an abnormal implantation of the placenta into the uterine wall. The incidence of placenta accreta has increased significantly over the past several decades, with the main risk factors include prior cesarean section and placent...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2013.06.014

    authors: Abuhamad A

    更新日期:2013-10-01 00:00:00

  • First trimester Down syndrome screening: public health implications.

    abstract::Down syndrome (DS) screening has been an integral part of routine prenatal screening for the last three decades. Recent efforts have been directed at developing additional non-invasive prenatal screening techniques that could not only improve sensitivity of prenatal screening, but also be employed in the first trimest...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1053/j.semperi.2005.05.003

    authors: Fuchs KM,Peipert JF

    更新日期:2005-08-01 00:00:00

  • Conducting research during the COVID-19 pandemic.

    abstract::The highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected every aspect of medical practice and has all but ceased clinical, translational and basic science research. Pregnant women appear to be similarly affected by the virus as non-pregnant adults. As obstetricians, not only do w...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.semperi.2020.151287

    authors: Mourad M,Bousleiman S,Wapner R,Gyamfi-Bannerman C

    更新日期:2020-11-01 00:00:00

  • Before the horse is out of the barn: fetal surgery for hydrops.

    abstract::Hydrops fetalis, a condition characterized by abnormal accumulation of fluid and edema in the fetus, is the final common pathway in a number of pathological conditions. The diagnosis of hydrops is based on ultrasonographic findings of generalized edema along with a serous effusion (ascites, pleural effusion, or perica...

    journal_title:Seminars in perinatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0146-0005(05)80053-9

    authors: Bullard KM,Harrison MR

    更新日期:1995-12-01 00:00:00