Abstract：
:Medium- and long-term outcomes have been collected and described among survivors of neonatal intensive care units for decades, for a number of purposes: (1) quality control within units, (2) comparisons of outcomes between NICUs, (3) clinical trials (whether an intervention improves outcomes), (4) end-of-life decision-making, (5) to better understand the effects of neonatal conditions and/or interventions on organs and/or long-term health, and finally (6) to better prepare parents for the future. However, the outcomes evaluated have been selected by investigators, based on feasibility, availability, cost, stability, and on what investigators consider to be important. Many of the routinely measured outcomes have major limitations: they may not correlate well with long-term difficulties, they may artificially divide continuous outcomes into dichotomous ones, and may have no clear relationship with quality of life and functioning of children and their families. Several investigations, such as routine term cerebral resonance imaging for preterm infants, have also not yet been shown to improve the outcome of children nor their families. In this article, the most common variables used in neonatology as well as some variables which are rarely measured but may be of equal importance for families are presented. The manner in which these outcomes are communicated to families will be examined, as well as recommendations to optimize communication with parents.
journal_name
Semin Perinatoljournal_title
Seminars in perinatologyauthors
Janvier A,Farlow B,Baardsnes J,Pearce R,Barrington KJdoi
10.1053/j.semperi.2016.09.009subject
Has Abstractpub_date
2016-12-01 00:00:00pages
571-577issue
8eissn
0146-0005issn
1558-075Xpii
S0146-0005(16)30081-7journal_volume
40pub_type
杂志文章,评审abstract：:Neonatal hyperinsulinism (HI) is a clinical syndrome of pancreatic beta-cell dysfunction characterized by failure to suppress insulin secretion in the presence of hypoglycemia. Although rare, it is the most common cause for persistent hypoglycemia in the newborn period. Treatment can be extremely difficult, and partia...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sp.2000.6365
更新日期：2000-04-01 00:00:00
abstract：:Inhalation of nitric oxide (NO) is an experimental treatment for severe pulmonary hypertension. Being rapidly metabolized by hemoglobin, inhaled NO causes selective vasodilation in the pulmonary vascular bed. In addition to the vascular smooth muscle, other pulmonary structures are exposed to inhaled NO, resulting in ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0146-0005(96)80046-2
更新日期：1996-06-01 00:00:00
abstract：:Intrauterine growth restriction (IUGR), which complicates approximately 3% to 10% of all pregnancies leads to preferential hemodynamic changes in affected fetuses. Advanced ultrasound modalities allow reliable and reproducible assessment of the intrauterine fetal cardiac function. Among other methods, combined cardiac...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2008.02.010
更新日期：2008-06-01 00:00:00
abstract：:Venous thromboembolism (VTE) is a leading cause of severe maternal morbidity and mortality. While pregnancy alone is a risk factor for VTE, additional population-based risk factors such as obesity are becoming increasingly common, particularly in the developed world. Maternal death from VTE is amenable to prevention a...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2015.11.011
更新日期：2016-03-01 00:00:00
abstract：:STDs can be one of the most common antepartum complications in high-risk gravidas. Screening for gonorrhea, syphilis, HPV, and possibly hepatitis B and chlamydial infection, should be considered in most, if not all, pregnant women. Familiarity with the common clinical presentations and treatment of bacterial STDs will...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1990-04-01 00:00:00
abstract：:Pharmacotherapy, or medication-assisted treatment (MAT), is a critical component of a comprehensive treatment plan for the pregnant woman with opioid use disorder (OUD). Methadone and buprenorphine are two types of opioid-agonist therapy which prevent withdrawal symptoms and control opioid cravings. Methadone is a lon...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.01.003
更新日期：2019-04-01 00:00:00
abstract：:Infection is a serious complication among very low birth weight (VLBW) preterm infants hospitalized in neonatal intensive care units. This article reviews studies from the National Institute of Child Health and Human Development (NICHD) Neonatal Research Network including infection data from observational studies and ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0146-0005(03)00046-6
更新日期：2003-08-01 00:00:00
abstract：:The ductus arteriosus is a vital fetal structure designed to close shortly after birth. Although many physiologic and pharmacologic investigations have characterized the closure of this structure, genetic studies of persistent patency of the ductus arteriosus (patent ductus arteriosus, PDA) are relatively recent. Prog...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2011.09.019
更新日期：2012-04-01 00:00:00
abstract：:This review evaluates and compares, by using the best available medical evidence, the risks and benefits of postnatal steroid use in very low birth weight infants. Systemic postnatal steroids are effective at reducing the risk of chronic lung disease in ventilated very low birth weight infants; they appear to be most ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/sper.2001.29034
更新日期：2001-12-01 00:00:00
abstract：:Classical and subtypes of kernicterus associated with bilirubin toxicity can be differentiated in part with physiological auditory measures that include auditory-evoked potentials and measures of cochlear integrity. The combination of these auditory measures suggests that bilirubin exposure results in auditory system ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2011.02.011
更新日期：2011-06-01 00:00:00
abstract：:The American Heart Association (AHA) categorizes pulmonary embolism (PE) into three main categories based on the presence or absence of hemodynamic changes and evidence of right ventricular dysfunction. The AHA characterizes massive PE as occurring in the setting of persistent hypotension, profound bradycardia, or pul...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:This article presents an overview of current topics related to the genetics of hearing loss. The review focuses on the approach toward a child with a sensorineural hearing loss of unknown etiology and the incorporation of genetic testing into the workup. Nongenetic causes of hearing loss are reviewed, as they are impo...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2004.12.002
更新日期：2005-06-01 00:00:00
abstract：:The studies described above collectively suggest that, whenever there is a decrease in fluid balance in the fetus, both fetal urine flow and tracheal secretion into the amniotic space are decreased. Conversely, when fetal hydration is increased, both urine and tracheal flows into the amniotic fluid may be increased. T...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1986-04-01 00:00:00
abstract：:Laboratory tests are critical in the detection and timely treatment of infection. Two categories of tests are commonly used in neonatal sepsis management: those that identify the pathogen and those that detect host response to a potential pathogen. Decision-making around antibiotic choice is related to the performance...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1016/j.semperi.2020.151328
更新日期：2020-12-01 00:00:00
abstract：:Morbidly adherent placenta, which describes placenta accreta, increta, and percreta, implies an abnormal implantation of the placenta into the uterine wall. The incidence of placenta accreta has increased significantly over the past several decades, with the main risk factors include prior cesarean section and placent...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2013.06.014
更新日期：2013-10-01 00:00:00
abstract：:Late preterm infants (34-37 weeks postmenstrual age at birth) are intermediate between less mature preterm infants and infants born at 38 weeks or more in regard to autonomic brain stem maturation. Ventilatory responses to CO(2) in preterm infants born at 33 to 36 week are significantly higher than in infants born at ...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2006.02.005
更新日期：2006-04-01 00:00:00
abstract：:Diagnostic errors remain understudied in neonatology. The limited available evidence, however, suggests that diagnostic errors in the neonatal intensive care unit (NICU) result in significant and long-term consequences. In this narrative review, we discuss how the concept of diagnostic errors framed as missed opportun...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.08.004
更新日期：2019-12-01 00:00:00
abstract：:Cesarean birth (CB) rates are rising, globally. The global burden of CB is having a mixed effect on pregnancy outcomes and requires significant clinical and economic resources. The context of CB care in low- and middle-income countries is further complicated by barriers to facility-based care itself, followed by issue...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2019.03.015
更新日期：2019-08-01 00:00:00
abstract：:Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes. Pregnancy places predisposed wo...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2014.04.019
更新日期：2014-08-01 00:00:00
abstract：:Despite major advances in neonatal care, the burden of preterm birth remains high. This is not unexpected since strategies to identify and treat risk factors in early pregnancy have not been very effective in reducing the preterm birth rate. Initial studies suggested a potential benefit for 17-alpha-hydroxyprogesteron...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2016.03.002
更新日期：2016-08-01 00:00:00
abstract：:Nonsteroidal anti-inflammatory drugs are frequently used during pregnancy (premature labor, polyhydramnios) and the immediate postnatal period (closure of patent ductus arteriosus). This article evaluates the renal effect of 3 nonspecific COX inhibitors (aspirin, indomethacin, and ibuprofen) in newborn rabbits. Five g...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/sper.2002.37310
更新日期：2002-12-01 00:00:00
abstract：:Tumors are a rare but important cause of mortality and morbidity in the neonate. There is a wide spectrum of benign and malignant tumors that can occur, some of which have a unique presentation and behavior in this age group. It is important to recognize that tumors such as stage IVS neuroblastoma, which have a good p...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0146-0005(97)80026-2
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Pulmonary inflammation, increased production of the inflammatory cytokine interleukin-1beta (IL-1beta), and vitamin A deficiency are risk factors for the development of bronchopulmonary dysplasia (BPD) in premature infants. To determine the mechanisms by which IL-1beta influences lung development, we have ge...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2006.04.009
更新日期：2006-06-01 00:00:00
abstract：:Extracorporeal membrane oxygenation (ECMO) is a highly technical and complex method of life support. Patient and circuit emergencies on ECMO are rare, but in these cases, prompt and correct actions to address the crisis are needed to prevent morbidity and mortality. ECMO simulation programs have gained popularity in r...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2016.08.002
更新日期：2016-11-01 00:00:00
abstract：:Use of immunosuppressants during pregnancy is indicated for anti-rejection therapy in transplantation patients and treatment of autoimmune diseases. Maternal side effects include nephrotoxocity and hepatotoxicity. All immunosuppressant drugs cross the placenta. Immunosuppressant use during the first trimester is not s...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0146-0005(97)80057-2
更新日期：1997-04-01 00:00:00
abstract：:Many infants with CDH can be managed with conventional mechanical ventilation and pharmacotherapy. However, some infants will require levels of ventilator support that are not compatible with survival. In these circumstances, extracorporeal membrane oxygenation (ECMO) has been used with varying results. The indication...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2005.04.005
更新日期：2005-04-01 00:00:00
abstract：:Fetal and neonatal alloimmune thrombocytopenia is not a well-known disease, except among specialists in maternal-fetal medicine, neonatologists, and certain pediatricians (ie, hematologists). However, this is by far the most common cause of early severe thrombocytopenia in neonates and of intracranial hemorrhage in te...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2008.10.003
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Cardiovascular disease is the major cause of pregnancy-related maternal mortality in the United States, and congenital heart disease (CHD) is the most common form of structural heart disease affecting women of childbearing age. Most females born with CHD will reach childbearing age and consider pregnancy. Adu...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2017.11.008
更新日期：2018-02-01 00:00:00
abstract：:Newborn screening (NBS) reaches approximately all of the 4 million newborns in the United States each year and has been effective in significantly reducing the morbidity and mortality that results from certain congenital conditions. The comprehensive NBS system can be divided into preanalytic (education and screening)...
journal_title：Seminars in perinatology
pub_type： 杂志文章
doi：10.1053/j.semperi.2009.12.002
更新日期：2010-04-01 00:00:00
abstract：:Supplemental oxygen is often used as a life-saving therapy in the treatment of preterm infants. However, its protracted use can lead to the development of bronchopulmonary dysplasia (BPD), and more recently, has been associated with adversely affecting the general health of children and adolescents who were born prete...
journal_title：Seminars in perinatology
pub_type： 杂志文章,评审
doi：10.1053/j.semperi.2013.01.002
更新日期：2013-04-01 00:00:00
