Abstract:
:Despite major advances in neonatal care, the burden of preterm birth remains high. This is not unexpected since strategies to identify and treat risk factors in early pregnancy have not been very effective in reducing the preterm birth rate. Initial studies suggested a potential benefit for 17-alpha-hydroxyprogesterone caproate (17-OHPC) in decreasing the risk of recurrent preterm birth women with a singleton gestation. However, the use of 17-OHPC has not conferred benefit for other categories of women at high risk for preterm delivery (twins, triplets, and short cervical length). The increasing body of evidence suggests that preterm birth is a complex condition with variable mechanisms of disease and significant individual heterogeneity. This review will examine the plausibility of 17-OHPC in preventing preterm birth and the investigation of its clinical efficacy. We will also highlight factors to explain variations in clinical trial outcomes and outline the trajectory needed for future investigations.
journal_name
Semin Perinatoljournal_title
Seminars in perinatologyauthors
Caritis SN,Feghali MN,Grobman WA,Rouse DJ,Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network.doi
10.1053/j.semperi.2016.03.002subject
Has Abstractpub_date
2016-08-01 00:00:00pages
273-80issue
5eissn
0146-0005issn
1558-075Xpii
S0146-0005(16)00010-0journal_volume
40pub_type
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
pub_type: 杂志文章,评审
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
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journal_title:Seminars in perinatology
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