What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth.

Abstract:

:Despite major advances in neonatal care, the burden of preterm birth remains high. This is not unexpected since strategies to identify and treat risk factors in early pregnancy have not been very effective in reducing the preterm birth rate. Initial studies suggested a potential benefit for 17-alpha-hydroxyprogesterone caproate (17-OHPC) in decreasing the risk of recurrent preterm birth women with a singleton gestation. However, the use of 17-OHPC has not conferred benefit for other categories of women at high risk for preterm delivery (twins, triplets, and short cervical length). The increasing body of evidence suggests that preterm birth is a complex condition with variable mechanisms of disease and significant individual heterogeneity. This review will examine the plausibility of 17-OHPC in preventing preterm birth and the investigation of its clinical efficacy. We will also highlight factors to explain variations in clinical trial outcomes and outline the trajectory needed for future investigations.

journal_name

Semin Perinatol

journal_title

Seminars in perinatology

authors

Caritis SN,Feghali MN,Grobman WA,Rouse DJ,Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network.

doi

10.1053/j.semperi.2016.03.002

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

273-80

issue

5

eissn

0146-0005

issn

1558-075X

pii

S0146-0005(16)00010-0

journal_volume

40

pub_type

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