Abstract:
:Hyperacusis may be defined as diminishing tolerance to moderate and high intensity sounds in people with normal hearing sensitivity. Serotonin plays a critical role in some of auditory tasks including startle reflex and prepulse inhibition. Serotonin deficiency can cause some diseases which can coincide with hyperacusis. The aim of the present study was to investigate the probable influence of serotonergic depletion in nucleus accumbens (NAcc) on the startle reflex. The startle reflexes were examined in Wistar rats (n: 48) in different intensities with and without the background noise. The amplitude of startle reflex significantly increased in NAcc-injected rats without background noise, while this difference disappeared in the presence of background noise in all intensities. These data proposed that the injection of 5, 7-Dihydroxytryptamine (5, 7-DHT) into nucleus accumbens will cause hyperacusis-like behavior, and strengthens the possibility of the role of serotonin and nucleus accumbens in hyperacusis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Farahani S,Nasirinezhad F,Danyali S,Jalaei S,Shahbazi A,Karimi M,Mokrian Hdoi
10.1016/j.neulet.2019.01.040subject
Has Abstractpub_date
2019-07-13 00:00:00pages
246-250eissn
0304-3940issn
1872-7972pii
S0304-3940(19)30052-7journal_volume
705pub_type
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