Abstract:
:Post-traumatic hypopituitarism (PTHP) is an important and relatively common complication of TBI (traumatic brain injury). A number of studies have shown that this clinical phenomenon can occur soon after TBI (acute) or later in the chronic phase. Patients with moderate to severe TBI are at a particular risk of developing PTHP. In the acute setting, it is important to monitor patients for hypoadrenalism as this confers a high risk for morbidity and even mortality. The gonadotrophin, growth hormone and TSH deficiencies are better defined in the chronic phase. Untreated PTHP can lead to delayed recovery, impaired rehabilitation and persistent neuropsychiatric symptoms. This review will discuss the frequency and natural history of PTHP and its clinical implications and propose a pathway for investigation and management of this still under-recognised entity.
journal_name
Ir J Med Scijournal_title
Irish journal of medical scienceauthors
Kgosidialwa O,Agha Adoi
10.1007/s11845-019-02007-6subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1201-1206issue
4eissn
0021-1265issn
1863-4362pii
10.1007/s11845-019-02007-6journal_volume
188pub_type
杂志文章,评审abstract:BACKGROUND:Osteoid osteoma is a painful benign bone tumour. Previously the standard therapy was surgical excision. Image guided radiofrequency ablation can be clinically applied to ablate the tumour in a minimally invasive manner. AIMS:We present a case of an 18-year-old boy who presented with features of chronic left...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03169159
更新日期:2005-07-01 00:00:00
abstract::Self-instruction programmes comprise audio tapes and a variety of visual materials ranging from photographs to models. The use of such programmes in an anatomy course is described and illustrated. They are an effective ancillary in teaching and are applicable to other medical teaching disciplines. ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02938052
更新日期:1979-12-01 00:00:00
abstract:INTRODUCTION:We describe a case report and technique for using an ultrasound scanner and a linear transducer to guide serratus posterior superior (SPS) muscle injection. A 43-year-old female presented with chronic pain centered under the right upper portion of her scapula impacting her activities of daily living. METH...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1336-z
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:We describe a case of Cushing's syndrome due to ectopic ACTH secretion, where the only potential source on conventional imaging was a tiny benign-appearing lung nodule, which failed to take up radiolabelled octreotide. DESIGN AND METHODS:To determine whether the patient might respond to therapeutic administr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0171-x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). METHODS:We performe...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-008-0250-z
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:In 1996, Irish accident and emergency (A&E) departments had approximately 1.2 million visits. General practitioners (GPs) have been shown to work efficiently in A&E. AIM:This study aimed to describe the current A&E structures in Ireland and the potential contribution of general practice. METHOD:Questionnai...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03173524
更新日期:2000-10-01 00:00:00
abstract::The attitudes of a final year of medical students in University College Dublin and their level of satisfaction to their medical training was assessed. Medical students were significantly more dissatisfied with their pre-clinical teaching than clinical teaching and training. The majority of students felt inadequately t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944357
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Glycodelin plays an important role in normal and abnormal reproductive growth. The in vitro properties of glycodelin have been studied in K562 cells. The role of glycodelin in vivo in the peripheral circulation has not been determined. AIM:To determine if circulating leukocytes in normal subjects express th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-007-0019-9
更新日期:2007-07-01 00:00:00
abstract::The aim of this paper is to assess the adequacy of the diet of individuals over 60 yr of age, participating in the 1990 Irish National Nutritional Survey. A nationwide random sample based on the most recently updated electoral register was used. Demographic information was collected. Anthropometric measurements were t...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02944238
更新日期:1997-10-01 00:00:00
abstract::Eighty-one epithelial lesions were studied immunohistologically for cytokeratin protein expression using three anticytokeratins CAM 5.2, NCL5D3 and RCK102. Consistent differences were noted between squamous and glandular neoplasms. Squamous and cutaneous carcinomas were found to preferentially express higher molecular...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02942094
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Since their original description in 1687, aneurysms of the extracranial internal carotid artery (ICA) remain rare and account for less than 2% of all carotid operations (Zwolak et al. in: J Vasc Surg 1:415-422, 1984; El-Sabrout, Cooley in: J Vasc Surg 31:702-712, 2000). Cerebrovascular morbidity and mortalit...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-009-0353-1
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Rubella is caused by the rubella virus, a single-stranded RNA virus of the Togaviridae family. The most severe complications of rubella in adult women occur during pregnancy when infection can lead to miscarriage, stillbirth or congenital rubella syndrome. Antenatal rubella susceptibility screening is no lon...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1722-9
更新日期:2018-08-01 00:00:00
abstract::Liver failure resulting from deliberate or accidental paracetamol overdose continues to be an important reason for referral to liver transplant centres. Severe hepatic dysfunction often appears 72-96 h after overdose. Liver injury can be prevented by timely administration of the specific antidote, N-acetylcysteine. Un...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-011-0783-4
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis is an important cause of chronic pancreatitis, which may result in endocrine and exocrine failure. This may necessitate simultaneous pancreas and kidney transplant (SPK). Bladder drainage of the exocrine secretions may cause problems. AIM:To report one such case and its surgical corr...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02915290
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique po...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-019-01980-2
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Although good evidence exists regarding the clinical effectiveness of mechanical thrombectomy for people with acute ischaemic stroke, cost-effectiveness should also be considered. The aim of this study was to systematically review the evidence of cost-effectiveness of emergency endovascular therapy using mechan...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-018-1946-3
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers a...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1580-5
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Injecting drug use is associated with increased morbidity and mortality. This is the first longitudinal study of a community-based population of injecting drug users (IDUs) in the Republic of Ireland. AIM:To establish the natural history of IDUs in a deprived Dublin community. METHODS:Eighty-two IDUs (hero...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-012-0814-9
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Recent developments in the management of severe aortic stenosis have resulted in a paradigm shift in the way we view the condition. Patients previously denied intervention in the form of surgical aortic valve replacement (SAVR) are now candidates for transcatheter aortic valve implantation and the risk and a...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-016-1417-7
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Injuries to the cervical spine (C-spine) are among the most serious in rugby and are well documented. Front-row players are particularly at risk due to repetitive high-intensity collisions in the scrum. AIM:This study evaluates degenerative changes of the C-spine and associated symptomatology in front-row r...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-009-0432-3
更新日期:2010-06-01 00:00:00
abstract::The Dublin Soft Tissue Sarcoma Panel was established in 1989 with a view to achieving a unified approach to diagnosis and management of soft tissue and visceral sarcomas. This interim report presents data on 265 prospectively-evaluated patients and on a separate retrospective series of 126 patients. The patients in th...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02943260
更新日期:1994-05-01 00:00:00
abstract::In 2006, Dutch authorities introduced a new health financing system of compulsory private for-profit insurance with strong government regulation. This system has recently attracted attention in Ireland. This paper assesses the theoretical arguments and evidence for applying the Dutch ideas to Ireland. In particular, t...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-009-0365-x
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Internationally, the number of computerised tomographic pulmonary angiographies (CTPAs) being performed to rule out pulmonary embolism (PE) has caused some concern. AIM:This study was performed to assess if the application of Pulmonary Embolism Rule-out Criteria (PERC) in an Irish Emergency Department (ED) ...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-020-02398-x
更新日期:2020-10-22 00:00:00
abstract::Supervised machine learning (ML) is a class of algorithms that "learn" from existing input-output pairs, which is gaining popularity in pattern recognition for classification and prediction problems. In this scoping review, we examined the use of supervised ML algorithms for the prediction of long-term allograft survi...
journal_title:Irish journal of medical science
pub_type: 杂志文章,评审
doi:10.1007/s11845-020-02332-1
更新日期:2020-08-06 00:00:00
abstract:BACKGROUND:Laparoscopic cholecystectomy is the operation of choice for cholelithiasis. AIMS:The aims of our study were to assess the feasibility of day case laparoscopic cholecystectomy (DCLC) in selected patients. METHODS:DCLC was introduced in this unit in July 1999. The first 50 patients were prospectively evaluat...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF03168818
更新日期:2001-04-01 00:00:00
abstract:INTRODUCTION:Optimal risk factor control is integral to managing patients with proven coronary heart disease (CHD+) and for those at risk of coronary heart disease (CHD-). The primary aim of the study was to assess the success rate of reaching lipid risk factor targets in a multiple risk factor clinic. METHODS:A retro...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-013-0954-6
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:The purpose of this study is to introduce peer teaching of communication skills to first-year anaesthesia trainees in Ireland and to evaluate their perception of this teaching modality. METHODS:Seventy-nine first-year anaesthesia trainees participated in a novel peer-led communication skills programme over a 2...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1637-5
更新日期:2018-02-01 00:00:00
abstract::DNA, extracted from tumours arising in 29 paediatric patients [14 neuroblastoma, 9 Wilms tumour (nephroblastoma), 6 miscellaneous] was investigated for evidence of N-myc amplification, using pNb-1, a recombinant plasmid containing a 1.0 Kb fragment homologous to the 5' end of the human N-myc gene. Within the neuroblas...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/BF02937236
更新日期:1990-06-01 00:00:00
abstract:OBJECTIVE:To observe the preventive and therapeutic effects of diosgenin on retinoic acid-induced osteoporosis in rats. METHODS:A total 50 Sprague-Dawley rats were randomly divided into 5 groups: control group, model group (osteoporosis rats), low (10 mg kg(-1)), middle (30 mg kg(-1)), and high-dose diosgenin (90 mg k...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-015-1309-2
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:There is no agreeing if rescue therapy can avoid short-term colectomy in patients treated for severe steroid-refractory ulcerative colitis. AIMS:The aim of our study was to identify predictors of response to infliximab and cyclosporine A. METHODS:In this cross-sectional study, 49 patients with severe ulcer...
journal_title:Irish journal of medical science
pub_type: 杂志文章
doi:10.1007/s11845-017-1666-0
更新日期:2018-05-01 00:00:00