Hypopituitarism post traumatic brain injury (TBI): review.

Abstract:

:Post-traumatic hypopituitarism (PTHP) is an important and relatively common complication of TBI (traumatic brain injury). A number of studies have shown that this clinical phenomenon can occur soon after TBI (acute) or later in the chronic phase. Patients with moderate to severe TBI are at a particular risk of developing PTHP. In the acute setting, it is important to monitor patients for hypoadrenalism as this confers a high risk for morbidity and even mortality. The gonadotrophin, growth hormone and TSH deficiencies are better defined in the chronic phase. Untreated PTHP can lead to delayed recovery, impaired rehabilitation and persistent neuropsychiatric symptoms. This review will discuss the frequency and natural history of PTHP and its clinical implications and propose a pathway for investigation and management of this still under-recognised entity.

journal_name

Ir J Med Sci

authors

Kgosidialwa O,Agha A

doi

10.1007/s11845-019-02007-6

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1201-1206

issue

4

eissn

0021-1265

issn

1863-4362

pii

10.1007/s11845-019-02007-6

journal_volume

188

pub_type

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